Malignant Plasmacytoid Myoepithelioma of the Palate: Histological Observations Compared to Benign Predominant Plasmacytoid Myoepithelial Cells in Pleomorphic Adenoma of the Palate

1998 ◽  
Vol 22 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Hiroko Kuwabara ◽  
Hirotsugu Uda ◽  
Kazunori Miyabe ◽  
Katsuhiro Saito ◽  
Toshiyuki Shibanushi
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cells

Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development

2021 ◽  
Vol 157 ◽  
pp. 103195
Author(s):  
João Figueira Scarini ◽  
Erika Said Abu Egal ◽  
Reydson Alcides de Lima-Souza ◽  
Lívia Ramalho Crescencio ◽  
Carolina Emerick ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cells ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Two Sides

scholarly journals Pleomorphic adenoma of the upper lip: a case report and review of literature

2016 ◽  
Vol 4 (1) ◽  
pp. 8
Author(s):  
Rashmi Metgud ◽  
Bhardwaj Tina Neelesh ◽  
Saurabh Goel ◽  
Smitha Nail ◽  
Shrikant Patel ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Unusual Case ◽  
Needle Aspiration ◽  
Myoepithelial Cells ◽  
Upper Lip ◽  
Epithelial Tumor ◽  
Needle Aspiration Cytology ◽  
Benign Mixed Tumor ◽  
Morphological Patterns

<p>Pleomorphic Adenoma is a benign epithelial tumor arising from the salivary gland. It is a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. In this article, we report an unusual case of 30 year, male with a single, nodular swelling evident in the upper lip which was discovered during a routine dental procedure. Fine Needle Aspiration Cytology (FNAC) was planned for the patient, where a of cytological diagnosis of Pleomorphic Adenoma was rendered, which was confirmed by biopsy. Hence, this highlights, FNAC makes up an important diagnosing tool as the first line of investigation to distinguish between benign and malignant salivary gland neoplasms.</p>

scholarly journals Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

2014 ◽  
Vol 5 (2) ◽  
pp. 72-77
Author(s):  
Sudhir Naik ◽  
Rajshekar Halkud ◽  
KT Siddappa ◽  
Akshay Shivappa ◽  
Siddharth Biswas ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
Hard Palate ◽  
De Novo ◽  
Metastatic Tumor ◽  
Myoepithelial Cells ◽  
Concurrent Chemotherapy ◽  
Adjuvant Chemoradiotherapy ◽  
Myoepithelial Carcinoma ◽  
Diagnostic Dilemma ◽  
Aggressive Tumor

ABSTRACT Background/Objectives Myoepithelial carcinomas are uncommon neoplasms that account for about 10% of all myoepitheliomas. The invasiveness varies from a locally aggressive to highly metastatic tumor which may arise de novo or in a pleomorphic adenoma. Myoepitheliomas arise from myoepithelial cells lacking ductal differentiation which exhibit both epithelial and smooth muscle cell elements. Case report We report a case of palatal swelling excised 4 years back, as pleomorphic adenoma, which later recurred as malignant myoepithelial carcinoma expleomorphic adenoma of the palate. CECT of the paranasal air sinuses did not show any bony invasion of the hard palate. So he was given radical radiotherapy with concurrent chemotherapy but after 3 years developed recurnce and metastasis to the skin and the lungs. The patient was referred to oral chemotherapy on a palliative basis. Conclusion Malignant myoepithelial carcinoma expleomorphic adenoma of the hard palate is a highly aggressive rare tumor of the hard palate. Radical management with surgery and adjuvant chemoradiotherapy improves survival in these patients. Followup with metastatic workup should be accurate as the tumor is highly aggressive with poor prognosis. How to cite this article Shenoy AM, Halkud R, Shivappa A, Chavan p, Sunil KC, Sarvadyna J, Samskruthi M, Siddappa KT, Biswas S, Naik SM. Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard palate: An Aggressive Tumor with Diagnostic Dilemma. Int J Head Neck Surg 2014;5(2):72-77.

scholarly journals Cystic and florid squamous metaplasia in pleomorphic adenoma of palate – A diagnostic dilemma

2014 ◽  
Vol 5 (4) ◽  
pp. 108-110 ◽  
Author(s):  
H Kaveri ◽  
K Gopalkrishnana ◽  
Anehosur Venkatesh
Keyword(s):  
Pleomorphic Adenoma ◽  
Myoepithelial Cell ◽  
Benign Tumor ◽  
Squamous Metaplasia ◽  
Myoepithelial Cells ◽  
Cystic Degeneration ◽  
Minor Trauma ◽  
Medical Sciences ◽  
Diagnostic Dilemma

Pleomorphic adenoma is a benign tumor of salivary gland. Controversy regarding the origin of various mesenchymal components exists and myoepithelial cell has a key role. Metaplastic process is triggered by minor trauma and probable etiology for this change is ischemia. It is diagnostically challenging, because diagnostic pit falls in the presence of mucinous and squamous metaplasia. Report a case of pleomorphic adenoma in the palate of a 35 years old Indian female. Biopsy revealed epithelial component with extensive squamous metaplasia and cystic degeneration. Here we discuss the role of myoepithelial cells in the pathogenesis of pleomorphic adenoma and diagnostic pit falls. DOI: http://dx.doi.org/10.3126/ajms.v5i4.10434 Asian Journal of Medical Sciences 2014 Vol.5(4); 108-110

scholarly journals Pleomorphic Adenoma of Lacrimal Gland: A Rare Entity

2021 ◽  
Vol 8 (7) ◽  
pp. C100-104
Author(s):  
Kirti Chadha Kazi ◽  
Vivek Choodamani Parameshwar ◽  
Vikas S Kavishwar ◽  
Prithesh Bhaskar Shetty
Keyword(s):  
Pleomorphic Adenoma ◽  
Lacrimal Gland ◽  
Histopathological Examination ◽  
Mass Effect ◽  
Final Diagnosis ◽  
Myoepithelial Cells ◽  
Significant Loss ◽  
Excision Biopsy ◽  
Post Surgery ◽  
Rare Tumours

Among the various tumours affecting the lacrimal gland, pleomorphic adenomas though most common can present clinically and radiologically as worrisome tumours. Histopathologic diagnosis hence is very critical for these tumours. We present a case of pleomorphic adenoma of the lacrimal gland which we encountered at our institutes. The patient was a 46-year-old male who came with complaints of a gradually progressing swelling in the right eye not associated with much pain or significant loss of vision. MRI revealed a large lobulated extrachoanal mass causing mass effect and scalloping of the adjacent bony structures. An excision biopsy was done and sent for histopathological examination. Histologically the tumour showed a biphasic morphology comprising of epithelial (ductal and myoepithelial) and chondromyxoid stromal components. Immunohistochemistry showed positivity for pan CK and CK 7 in ductal epithelial cells, p63 and S100 in myoepithelial cells and a low Ki67 index. On the basis of immunohistochemistry profile along with clinicoradiological correlation a final diagnosis of pleomorphic adenoma of the lacrimal gland was made. The patient post-surgery was doing well but was lost to follow up. It can thus be seen that is it absolutely necessary to accurately diagnose these benign but clinically misconceiving rare tumours of the lacrimal gland for appropriate management of such patients.

scholarly journals Pleomorphic Adenoma of the Ala Nasi: A Case Report

2019 ◽  
Vol 12 ◽  
pp. 117955061988656
Author(s):  
Amina Mouzali ◽  
Samia Lameche ◽  
Assia Slimani ◽  
Omar Zemirli
Keyword(s):  
Pleomorphic Adenoma ◽  
Minor Salivary Gland ◽  
Surgical Excision ◽  
Myoepithelial Cells ◽  
Benign Tumors ◽  
Complete Surgical Excision ◽  
External Nose ◽  
Pleomorphic Adenomas ◽  
Long Term Follow Up ◽  
The Right

Objectives: Pleomorphic adenomas are benign tumors that rarely involve nonsalivary glands. We report an uncommon case of ala nasi pleomorphic adenoma. We discuss the clinical and histopathologic characteristics, and review the literature on nasal pleomorphic adenoma. Method: A 20-year-old man presented with a painless slow growing lobulated mass located on the right ala nasi extending into the nasal vestibule. Results: Complete surgical excision was performed. Histologic examination found a mixed cellular component: epithelial and myoepithelial cells with chondromyxoid stroma. This was consistent with the diagnosis of a typical pleomorphic adenoma. There was no evidence of recurrence at 18 months after the surgery. Conclusions: Pleomorphic adenomas located in the external nose are extremely rare. In such case, pleomorphic adenoma could originate from ectopic minor salivary gland. Complete surgical excision with long-term follow-up is recommended due to the potential risk of recurrence and malignant transformation.

Ultrastructural Contributions to the Histogenesis of Pleomorphic Adenoma

1982 ◽  
Vol 40 ◽  
pp. 218-219
Author(s):  
I. Dardick ◽  
A.W.P. van Nostrand ◽  
Diane Jeans ◽  
P. Rippstein ◽  
V. Edwards
Keyword(s):  
Epithelial Cells ◽  
Tumor Cells ◽  
Pleomorphic Adenoma ◽  
Cell Types ◽  
Myoepithelial Cells ◽  
Luminal Type ◽  
Cell Processes ◽  
Luminal Cells ◽  
Sick Children ◽  
Luminal Epithelial Cells

Hospital, Ottawa, Canada and ^Hospital for Sick Children, Toronto, Canada. Survey-type electron micrographs correlated with semithin plastic sections (Fig. 2) were used in an ultrastructural study of 24 cases of salivary gland pleomorphic adenoma in order to assess tumor cell types and their organization in cellular regions and the gradual alterations occurring with the development of myxoid areas. Such micrographs confirm the presence of two principal cell types with smaller numbers of highly organized luminal epithelial cells forming duct- or acinar-like structures and more numerous, angular, mosaically or loosely arranged tumor cells surrounding luminal type cells. As is evident in Figure 1, darker staining, angular tumor cells just external to duct luminal cells have a specific and intimate association with luminal cells through cell processes and well developed desmosomes. Despite the lack of classical features of myoepithelial cells, the organizational arrangement of the two cell types and the distinctly different cytologic features of tumor cells external to luminal epithelial cells suggests that the former cell type represents myoepithelial cells modified as a result of neoplastic induction (Figs. 1 and 2).

The EGF signaling pathway influences cell migration and the secretion of metalloproteinases by myoepithelial cells in pleomorphic adenoma

Tumor Biology ◽  
2014 ◽  
Vol 36 (1) ◽  
pp. 205-211 ◽  
Author(s):  
Natalia Festugatto Navarini ◽  
Vera Cavalcanti de Araújo ◽  
Amy Louise Brown ◽  
Fabrício Passador-Santos ◽  
Isabela Fernandes de Souza ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathway ◽  
Pleomorphic Adenoma ◽  
Myoepithelial Cells ◽  
Egf Signaling
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