Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells

2011 ◽  
Vol 37 (10) ◽  
pp. 606-614 ◽  
Author(s):  
JeanClare Seagrave ◽  
Helmut Albrecht ◽  
Yong Sung Park ◽  
Bruce Rubin ◽  
Gail Solomon ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Mucociliary Transport ◽  
Airway Epithelial ◽  
Mucin Production ◽  
Human Airway ◽  
Human Airway Epithelial Cells

scholarly journals Effect of Berberine on MUC5AC Mucin Gene Expression and Mucin Production from Human Airway Epithelial Cells

2011 ◽  
Vol 19 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Md. Asaduzzaman Sikder ◽  
Hyun-Jae Lee ◽  
Su-Yel Lee ◽  
Heung-Seog Bae ◽  
Jang-Hyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Production ◽  
Human Airway ◽  
Mucin Gene ◽  
Human Airway Epithelial Cells

scholarly journals Effects of hydrogen peroxide on mucociliary transport in human airway epithelial cells

2014 ◽  
Vol 24 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Akiko Honda ◽  
Rumiko Murayama ◽  
Yugo Matsuda ◽  
Kenshi Tsuji ◽  
Takahiro Sawahara ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Mucociliary Transport ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells

2006 ◽  
Vol 154 (3) ◽  
pp. 484-499 ◽  
Author(s):  
Daisuke Inoue ◽  
Mutsuo Yamaya ◽  
Hiroshi Kubo ◽  
Takahiko Sasaki ◽  
Masayoshi Hosoda ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Production ◽  
Human Airway ◽  
Rhinovirus Infection ◽  
Human Airway Epithelial Cells

Macrolides Attenuate Phorbol Ester-Induced Tumor Necrosis Factor-a and Mucin Production from Human Airway Epithelial Cells

Pharmacology ◽  
2014 ◽  
Vol 93 (1-2) ◽  
pp. 92-99 ◽  
Author(s):  
Orapan Poachanukoon ◽  
Sittichai Koontongkaew ◽  
Paopanga Monthanapisut ◽  
Napaporn Pattanacharoenchai
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Phorbol Ester ◽  
Tumor Necrosis ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Mucin Production ◽  
Human Airway ◽  
Necrosis Factor ◽  
Human Airway Epithelial Cells

scholarly journals Continuous mucociliary transport by primary human airway epithelial cells in vitro

2015 ◽  
Vol 309 (2) ◽  
pp. L99-L108 ◽  
Author(s):  
Patrick R. Sears ◽  
Wei-Ning Yin ◽  
Lawrence E. Ostrowski
Keyword(s):  
Epithelial Cells ◽  
Beat Frequency ◽  
Multicomponent System ◽  
Airway Epithelial Cells ◽  
Mucociliary Transport ◽  
Airway Epithelial ◽  
Innate Defense ◽  
Human Airway ◽  
Human Airway Epithelial Cells

Mucociliary clearance (MCC) is an important innate defense mechanism that continuously removes inhaled pathogens and particulates from the airways. Normal MCC is essential for maintaining a healthy respiratory system, and impaired MCC is a feature of many airway diseases, including both genetic (cystic fibrosis, primary ciliary dyskinesia) and acquired (chronic obstructive pulmonary disease, bronchiectasis) disorders. Research into the fundamental processes controlling MCC, therefore, has direct clinical application, but has been limited in part due to the difficulty of studying this complex multicomponent system in vitro. In this study, we have characterized a novel method that allows human airway epithelial cells to differentiate into a mucociliary epithelium that transports mucus in a continuous circular track. The mucociliary transport device allows the measurement and manipulation of all features of mucociliary transport in a controlled in vitro system. In this initial study, the effect of ciliary beat frequency and mucus concentration on the speed of mucociliary transport was investigated.

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