https://researchopenworld.com/bladder-necrosis-due-to-septic-shock/#

doi:10.31038/srr.2020311

Low-Dose Steroids Cut Mortality in Septic Shock

Family Practice News ◽

10.1016/s0300-7073(06)73943-3 ◽

2006 ◽

Vol 36 (19) ◽

pp. 24

Author(s):

BRUCE JANCIN

Keyword(s):

Septic Shock ◽

Low Dose

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Septic shock patient and ultrasound in the emergency room

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0036-1587960 ◽

2016 ◽

Vol 37 (S 01) ◽

Author(s):

M Algaba Montes ◽

AÁ Oviedo García ◽

M Patricio Bordomás

Keyword(s):

Septic Shock ◽

Emergency Room ◽

Septic Shock Patient

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Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642520 ◽

1994 ◽

Vol 71 (06) ◽

pp. 768-772 ◽

Cited By ~ 14

Author(s):

Gerhard Dickneite ◽

Jörg Czech

Keyword(s):

Septic Shock ◽

Klebsiella Pneumoniae ◽

Organ Failure ◽

Therapeutic Effect ◽

Disseminated Intravascular Coagulation ◽

Post Infection ◽

Thrombin Inhibitor ◽

Bolus Administration ◽

Bacterial Burden ◽

Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

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Evidence for impaired 21-hydroxylase activity in patients with septic shock

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2004-819299 ◽

2004 ◽

Vol 112 (S 1) ◽

Author(s):

MWA Angstwurm ◽

A Rashidi-Kia ◽

M Bidlingmeier ◽

J Schopohl ◽

R Gaertner

Keyword(s):

Septic Shock ◽

Hydroxylase Activity

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Arginine-Vasopressin in severe septic vs. non-septic shock in extremely low birth weight infants with acute renal failure

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2006-943137 ◽

2006 ◽

Vol 210 (S 5) ◽

Author(s):

S Meyer ◽

A Baghai ◽

G Löffler ◽

D Wurm ◽

S Gottschling ◽

...

Keyword(s):

Septic Shock ◽

Renal Failure ◽

Acute Renal Failure ◽

Birth Weight ◽

Low Birth Weight ◽

Arginine Vasopressin ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants

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Arginine-Vasopressin in severe septic vs. non-septic shock in extremely low birth weight infants with acute renal failure

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2006-946052 ◽

2006 ◽

Vol 210 (S 5) ◽

Author(s):

S Meyer ◽

A Baghai ◽

G Löffler ◽

D Wurm ◽

S Gottschling ◽

...

Keyword(s):

Septic Shock ◽

Renal Failure ◽

Acute Renal Failure ◽

Birth Weight ◽

Low Birth Weight ◽

Arginine Vasopressin ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants

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Effect of fluid bolus triggers and their combination on fluid responsiveness in optimization phase of severe sepsis and septic shock resuscitation

MedPharmRes ◽

10.32895/ump.mpr.2.3.27 ◽

2018 ◽

Vol 2 (3) ◽

pp. 27-32

Author(s):

Bien Le ◽

Dai Huynh ◽

Mai Tuan ◽

Minh Phan ◽

Thao Pham ◽

...

Keyword(s):

Blood Pressure ◽

Septic Shock ◽

Severe Sepsis ◽

Fluid Responsiveness ◽

Statistical Significance ◽

Venous Pressure ◽

Fluid Bolus ◽

Low Blood Pressure ◽

Low Central Venous Pressure ◽

Sepsis And Septic Shock

Objectives: to evaluate the fluid responsiveness according to fluid bolus triggers and their combination in severe sepsis and septic shock. Design: observational study. Patients and Methods: patients with severe sepsis and septic shock who already received fluid after rescue phase of resuscitation. Fluid bolus (FB) was prescribed upon perceived hypovolemic manifestations: low central venous pressure (CVP), low blood pressure, tachycardia, low urine output (UOP), hyperlactatemia. FB was performed by Ringer lactate 500 ml/30 min and responsiveness was defined by increasing in stroke volume (SV) ≥15%. Results: 84 patients were enrolled, among them 30 responded to FB (35.7%). Demographic and hemodynamic profile before fluid bolus were similar between responders and non-responders, except CVP was lower in responders (7.3 ± 3.4 mmHg vs 9.2 ± 3.6 mmHg) (p 0.018). Fluid response in low CVP, low blood pressure, tachycardia, low UOP, hyperlactatemia were 48.6%, 47.4%, 38.5%, 37.0%, 36.8% making the odd ratio (OR) of these triggers were 2.81 (1.09-7.27), 1.60 (0.54-4.78), 1.89 (0.58-6.18), 1.15 (0.41-3.27) and 1.27 (0.46-3.53) respectively. Although CVP < 8 mmHg had a higher response rate, the association was not consistent at lower cut-offs. The combination of these triggers appeared to raise fluid response but did not reach statistical significance: 26.7% (1 trigger), 31.0% (2 triggers), 35.7% (3 triggers), 55.6% (4 triggers), 100% (5 triggers). Conclusions: fluid responsiveness was low in optimization phase of resuscitation. No fluid bolus trigger was superior to the others in term of providing a higher responsiveness, their combination did not improve fluid responsiveness as well.

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