scholarly journals A Cross Sectional Study to Evaluate the Sensitivity and Specificity of agnetic Resonance Spectroscopy (MRS) in Diagnosing Intracranial Neoplastic Lesions

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Khandaker Abu Talha ◽  
Farhana Selina ◽  
MH Khan Pavel ◽  
Kamal Khan ◽  
Muhammad Shoyab
Keyword(s):  
Sensitivity And Specificity ◽  
Cross Sectional Study ◽  
Resonance Spectroscopy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neoplastic Lesions

Cognitive Performance and Neuro-Metabolites in HIV using 3T Magnetic Resonance Spectroscopy: A Cross-Sectional Study from India

2020 ◽  
Vol 18 ◽  
Author(s):  
Kartik Gupta ◽  
Shivabalan ◽  
Virendra Kumar ◽  
Surabhi Vyas ◽  
RM Pandey ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Motor Skills ◽  
Cross Sectional Study ◽  
Resonance Spectroscopy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Total N ◽  
Simple Motor

Background: Cognitive impairment in patients with human immunodeficiency virus (HIV) is associated with higher morbidity. The prevalence of and the metabolite changes in the brain associated with cognitive impairment in anti-retroviral therapy naïve patients with HIV is unknown. Objective: To estimate the prevalence of, and the neurometabolites associated with cognitive impairment in antiretroviral therapy (ART) naïve patients with HIV. Methods: We conducted a cross-sectional study among ART naïve patients with HIV aged 18-50 years in a tertiary care center in India. Cognition was tested using the Post Graduate Institute battery of brain dysfunction across five domains; memory, attentioninformation processing, abstraction executive, complex perceptual, and simple motor skills. We assessed the total N-acetyl aspartyl (tNAA), creatine (tCr) and glutamate + glutamine (Glx) using 3T magnetic resonance spectroscopy. Cognitive impairment was defined as an impairment in ≥2 domains. Results: Among 43 patients eligible for this study, the median age was 32 years (IQR 29, 40) and 30% were women. Median CD4 count and viral load were 317 cells/µL (IQR 157, 456) and 9.3 copies/ µL (IQR 1.4, 38), respectively. Impairment in at least one cognitive domain was present in 32 patients (74.4%). Impairment in simple motor skills and memory was present in 46.5% and 44% of patients, respectively. Cognitive impairment, defined by impairment in ≥2 domains, was found in 22 (51.2%) patients. There was a trend towards higher concentration of tNAA (7.3 vs. 7.0 mmol/kg), tGlx (9.1 vs. 8.2 mmol/kg), and tCr (5.5 vs. 5.2 mmol/kg) in the frontal lobe of patients with cognitive impairment vs. without cognitive impairment but it did not reach statistical significance (p>0.05 for all). There was no difference in the concentration of these metabolites in the two groups in the basal ganglia. Conclusions: There is a high prevalence of cognitive impairment in ART naïve patients with HIV. There is no difference in metabolites in patients with or without cognitive impairment. Further studies, with longitudinal follow-up, are required to understand the underlying pathophysiological mechanisms.

scholarly journals Maternal Pregnancy Associated Plasma Protein-A Levels in Late First Trimester as a Predictor of Miscarriage- A Cross-sectional Study

2021 ◽  
Author(s):  
Nivedita Sinha ◽  
Alpana Singh ◽  
BD Banerjee ◽  
Rachna Agarwal ◽  
Himsweta Srivastva
Keyword(s):  
Logistic Regression ◽  
Sensitivity And Specificity ◽  
Plasma Protein ◽  
Protein A ◽  
Predictive Marker ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asymptomatic Women

Indroduction: Miscarriage is the most common complication of pregnancy. Defective implantation is one of the common causes of miscarriage. Pregnancy Associated Plasma Protein-A (PAPP-A) is secreted from syncytiotrophoblast and it enables trophoblast invasion. Few studies have shown association of PAPP-A with miscarriage. However, there is limited data available to establish the role of PAPP-A as a predictive marker of miscarriage, especially in Indian population. Aim: To determine the potential of maternal PAPP-A level estimation in asymptomatic women in late first trimester (10-13 weeks) with viable foetus in predicting subsequent miscarriage. Materials and Methods: This was an observational, cross-sectional study conducted from November 2016 to April 2018 at University College of Medical Science and Guru Teg Bahadur Hospital, Delhi, India. Asymptomatic pregnant women (N=500) at 10-13 weeks of gestation were recruited from an antenatal clinic after confirmation of foetal viability. A 2 mL of blood sample was collected and serum PAPP-A level was measured. Independent t-test and Chi-square test was used to compare continuous data and Mann-Whitney U test was used to compare PAPP-A Multiple of Median (MOM). Logistic regression was used to estimate risk of miscarriage. Results: Out of 500 participants, 9 were lost to follow-up. From remaining N=491, 32 (6.5%) women had a miscarriage. PAPP-A levels were significantly decreased in miscarriage group compared to ongoing pregnancy group with median MOM 0.116 (0.080-0.17) and 1.25 (0.665-3.249) respectively (p-value <0.001). PAPP-A MOM value of ≤10th percentile sensitivity and specificity of detection of miscarriage was 81.25% and 94.98% and at ≤5th percentile sensitivity and specificity was 40.62% and 97.82%, respectively. Lower the percentile cut-off of serum PAPP-A value, higher was the specificity and positive predictive value for prediction of miscarriage. By applying logistic regression we found that if PAPP-A MOM decreases by 1 unit the chances of miscarriage increased by 1.2 times. By this model 63.2% of cases could be explained (Nagelkerke R Square=0.632). For prediction of pregnancies likely to miscarry, the area under Receiver Operator Characteristic (ROC) curve (95% CI) was 0.969 (0.955-0.983). Conclusion: Low serum PAPP-A levels from asymptomatic women in late 1st trimester is a good predictive marker of miscarriage.

scholarly journals Sensitivitas dan spesifisitas food consumption score dalam mengidentifikasi rawan pangan dengan parameter status gizi balita

2018 ◽  
Vol 6 (2) ◽  
pp. 102-108
Author(s):  
Aklesta Leni Firna ◽  
Azis Nur Bambang ◽  
Diana Nur Afifah
Keyword(s):  
Food Insecurity ◽  
Food Consumption ◽  
Sensitivity And Specificity ◽  
Food Access ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Specificity Test ◽  
Food Consumption Score ◽  
Precision And Accuracy

Background : Food consumption score (FCS) was one of indicators to measure the food insecurity that included some elements from food access and food consumption, but the sensitivity was different in each area so it was needed to do the sensitivity and specificity tests with the high precision and accuracy of parameter. Objectives : To do the sensitivity and specificity test of food consumption score to identify the food insecurity with parameter status of toddlers’ nutrition anthropometrically. Methods : Cross sectional study with total subjects 517 toddlers. Status of toddlers’ nutrition was counted according to zscore WHZ, WAZ, and HAZ. The FCS score was counted according to WFP formula.  Results : Sensitivity (Se) and specificity (Sp) FCS test with parameter of WHZ, WAZ, HAZ as followed Se=0 Sp=  ≥ 90%. Conclusion: The cut-off point of FCS that was set by WFP was non-sensitive in identifying the food insecurity with parameter status of toddlers’ nutrition.

scholarly journals Diagnostic Concordance between Random Upper Arm Circumference and Mid Upper Arm Circumference Measurements among Children Aged 6–59 Months in South Ethiopia: A Community-Based Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Juhar Admama Bamud ◽  
Afework Mulugeta Bezabih ◽  
Fentaw Wassie Feleke ◽  
Getahun Fentaw Mulaw
Keyword(s):  
Sensitivity And Specificity ◽  
Cross Sectional Study ◽  
Receiver Operating Curve ◽  
Sectional Study ◽  
Upper Arm ◽  
Cross Sectional ◽  
Arm Circumference ◽  
Diagnostic Concordance ◽  
Mid Upper Arm Circumference ◽  
Kappa Agreement

Random upper arm circumference (RUAC) is frequently used for malnutrition screening among children aged 6–59 months. However, inadequate evidence exists regarding its agreement with mid upper arm circumference (MUAC). This study examined diagnostic concordance between RUAC and standard MUAC measurements and tested RUAC’s ability for screening malnutrition among children aged 6–59 months. A cross-sectional study was conducted from April 30 to May 30/2015 in Ethiopia. Data were taken from a sample of 819 children aged 6–59 months with a simple random sampling technique. The data were analyzed using SPSS version 22 software. The kappa agreement level, sensitivity, and specificity were calculated. The receiver operating curve was prepared to determine the optimal cutoff RUAC for the sensitivity and specificity. With National Center for Health Statistics (NCHS) cutoff (12 cm), the performance of RUAC measurements in terms of sensitivity was low (44%). The kappa agreement level between the two measurements was 0.551 ( p value < 0.001). With the new WHO cutoff (12.5 cm), however, RUAC was improved in validity (sensitivity 81%), specificity 96.9%, and kappa agreement level (K = 0.807; p < 0.001 ).

scholarly journals Non-neoplastic Lesions of Gallbladder Among Cholecystectomy Specimens of a Tertiary Care Center: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (242) ◽  
pp. 834-838
Author(s):  
Dilasma Ghartimagar ◽  
Manish Kiran Shrestha ◽  
Adarsh Jhunjhunwala ◽  
Arnab Ghosh ◽  
Sushma Thapa ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Tertiary Care Center ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Neoplastic Lesions

Introduction: Gallbladder diseases are prevalent worldwide and present with a diverse histopathological spectrum. Mucosal irritation and chronic inflammation is considered as an important etiological factor for the mechanical or functional dysfunction of emptying of the gallbladder. This study aims to find the prevalence of non-neoplastic lesions of gallbladder among cholecystectomy specimens of a tertiary care center. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology, of a tertiary care center from January 2005 to December 2020. Ethical approval was taken from the Institutional Review Committee. All the patients who had undergone cholecystectomy procedures which showed non-neoplastic lesions were enrolled in the study. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion forbinary data. Results: Out of 4914 cholecystectomy specimens, 4852 (98.73%) (95% Confidence Interval= 98.42- 99.04) were non-neoplastic lesions. There were 1252 (25.8%) males and 3600 (74.2%) females with a male to female ratio of 1:2.87. Age ranged from 2 to 89 years with a mean age of 45±14.48 years. Gallbladder lesions were observed maximum in age group 41-50 years with 1200 (24.7%) cases. Among the non-neoplastic lesions, cholecystitis without any specific finding was the most common finding with 3028 (62.4%) cases followed by cholelithiasis with 1478 (30.5%) cases. Conclusions: The prevalence of non-neoplastic lesions of gallbladder is similar to other studies done in similar setings. Female predominance was noted in non-neoplastic lesions.

scholarly journals Accuracy of the Simplified Nutritional Appetite Questionnaire for Malnutrition and Sarcopenia Screening among Older Patients Requiring Rehabilitation

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2738
Author(s):  
Akio Shimizu ◽  
Ichiro Fujishima ◽  
Keisuke Maeda ◽  
Kenta Murotani ◽  
Tatsuro Inoue ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Older Patients ◽  
Older Persons ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Poor Appetite ◽  
Number Of Patients ◽  
Japanese Elderly ◽  
Sensitivity Specificity

This cross-sectional study aimed to examine the accuracy of the Simplified Nutritional Appetite Questionnaire (SNAQ) and the SNAQ for Japanese Elderly (SNAQ-JE) for the Global Leadership Initiative on Malnutrition (GLIM)-defined malnutrition and sarcopenia screening in older persons. We included 380 inpatients aged ≥65 years (mean age, 79.3 ± 7.9; 60.0% women) and admitted to rehabilitation units. Undernutrition and sarcopenia were diagnosed based on GLIM criteria and the Asian Working Group for Sarcopenia, respectively, using bioimpedance analysis. Poor appetite was defined as an SNAQ score of <14 points and an SNAQ-JE score of ≤14 points. The sensitivity, specificity, and accuracy of these tools for detecting poor appetite for GLIM-defined malnutrition and sarcopenia were assessed. The rates of GLIM-defined malnutrition and sarcopenia were 56.8% and 59.2%, respectively. The number of patients with poor appetite was 94 (24.7%) for the SNAQ and 234 (61.6%) for the SNAQ-JE. The sensitivity and specificity of the SNAQ measured against GLIM-defined malnutrition were 32.9% and 73.1%, respectively, and against sarcopenia were 29.8% and 70.2%, respectively. The sensitivity and specificity of the SNAQ-JE measured against GLIM-defined malnutrition were 82.6% and 51.0%, respectively, and against sarcopenia were 86.0% and 53.7%, respectively. The SNAQ-JE showed fair accuracy for GLIM-defined malnutrition and sarcopenia in older patients admitted to rehabilitation units.

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