scholarly journals Clinicopathological and Prognostic Outcomes of VEGF Expression in Resected Gastric Cancer Tissues. A Systematic Review

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Brian Mawalla ◽  
Xiaoxiao Luo ◽  
Phillipo L. Chalya ◽  
Xianglin Yuan
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Vegf Expression ◽  
Cancer Tissues ◽  
Resected Gastric Cancer

Abstract 3364: Evaluation of CD133/CD44 expression level in resected gastric cancer tissues after neoadjuvant chemotherapy

2010 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Takako Eguchi Nakajima ◽  
Hirokazu Taniguchi ◽  
Yousuke Horita ◽  
Kenkichi Masutomi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Expression Level ◽  
Cd44 Expression ◽  
Cancer Tissues ◽  
Resected Gastric Cancer

scholarly journals Postoperative chemo-radiotherapy versus chemotherapy for resected gastric cancer: A systematic review and meta-analysis

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Yu Yang Soon ◽  
Cheng Nang Leong ◽  
Jeremy Chee Seong Tey ◽  
Ivan Weng Keong Tham ◽  
Jiade Jay Lu
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Resected Gastric Cancer

Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues

Surgery ◽  
2009 ◽  
Vol 145 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Shinobu Ohnuma ◽  
Koh Miura ◽  
Akira Horii ◽  
Wataru Fujibuchi ◽  
Naoyuki Kaneko ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Splicing Variants ◽  
Cancer Tissues ◽  
Resected Gastric Cancer

scholarly journals A systematic review and network meta-analysis protocol of adjuvant chemotherapy regimens for resected gastric cancer

Medicine ◽  
2019 ◽  
Vol 98 (7) ◽  
pp. e14478
Author(s):  
Long Ge ◽  
Liangying Hou ◽  
Qingxia Yang ◽  
Yiting Wu ◽  
Xiue Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Adjuvant Chemotherapy ◽  
Meta Analysis ◽  
Resected Gastric Cancer ◽  
Analysis Protocol

Tumor VEGF expression and serum VEGF levels are independent prognostic factors in curatively resected gastric cancer patients

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4021-4021
Author(s):  
M. Pera ◽  
O. Vidal ◽  
J. Elizalde ◽  
A. Soriano ◽  
A. Volant ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Tumor Recurrence ◽  
Univariate Analysis ◽  
Vegf Expression ◽  
Gastric Cancer Patients ◽  
Resected Gastric Cancer ◽  
Related Survival

4021 Background: Increased serum and/or tumor vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) have been shown to predict poor survival in several neoplasms, but their prognostic value in gastric cancer (GC) remains unknown. Methods: Serum VEGF (S-VEGF) and uPA concentrations were measured by commercially available ELISA in 20 healthy controls and 97 GC patients (70% I-II stages) before an R0 gastric resection. Tumor expression of VEGF and uPA were assessed by immunohistochemistry. Additional variables, including demographic, histological and therapeutic data were also evaluated. Univariate (Kaplan-Meier, log-rank test) and multivariate (Cox regression) analyses were performed to select prognostic factors regarding survival and tumor recurrence. Results: S-VEGF, but not uPA levels were significantly higher in GC patients than in controls. After a mean follow-up of 47 ± 3 months, the probability of cancer-related survival at 2, 5, and 10 years was 86%, 69% and 59%, respectively. Univariate analysis identified tumor VEGF expression (p=0.001) and high (> 289 pg/ml) S-VEGF levels (p=0.045), along with pTMN stage, grade of curability, perineural invasion, lymph node ratio, and extent of lymphadenectomy as variables associated with cancer-related survival. The mean disease-free survival was 20 ± 3 months, the probability of tumor recurrence being 78%, 62% and 62% at 2, 5 and 10 years, respectively. Prognostic variables for recurrence were the same as those identified for survival. Multivariate analysis identified tumor VEGF expression and high S-VEGF levels as independent prognostic survival factors. Conclusions: After a long follow-up, tumor VEGF expression and S-VEGF levels are independent prognostic factors for recurrence and survival in curatively resected gastric cancer patients. Such markers for increased angiogenic activity might help to identify patients at high risk of recurrence that could mostly benefit from adjuvant therapies. It is tempting to speculate that trials assessing the potential benefit of a.ntiangiogenic agents might be particularly warranted in patients with resected GC and a highly angiogenic phenotype. No significant financial relationships to disclose.

Ultrastructural Cytochemical Study of Human Gastric Cancer: Observation of AKP ase,ACP ase,G6P ase,TPP ase and CO ase

1990 ◽  
Vol 48 (3) ◽  
pp. 254-255
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Du Wei Dong ◽  
Xu Ai Liam
Keyword(s):  
Gastric Cancer ◽  
Gastric Epithelium ◽  
Human Gastric Cancer ◽  
Electron Microscopic ◽  
Cytochemical Study ◽  
Electron Microscopic Cytochemistry ◽  
Cytochemical Reaction ◽  
Set Up ◽  
Cancer Tissues ◽  
Cytochemical Technique

The activities and distributions of AKPase ,ACPase,G6Pase,TPPase and COase in human normal gastric mucosa and gastric cancer tissues were studied histochemically at light microscopic level. These enzymes are the marker enzymes of cell membrane lysosome endoplasmic reticulum, Golgi apparatus and mitochondrion objectively. On the basis of the research we set up a special ultrastructural cytochemical technique and first researched into gastric cancer domesticly. Ultrastructural cytochemistry is also called electron microscopic cytochemistry. This new technique possesses both the sensitivity of cytochemical reaction andi the high resolution of electron microscope. It is characterized by direct observation,exact localization and the combination morphology with function.The distributions of AKPase,ACPase,G6Pase,TPPase and COase in 14 cases of gastric cancer and 1 case of gastric Denign lesion were studied ultrastructurally. The results showed: 1. normal gastric epithelium had no AKPase reaction. The reaction of ACPase,G6Pase,TPPase and Coase were found in the corresponding organella, which were consistent with their function.

Sign in / Sign up

Export Citation Format

Share Document