Synthesis and anti-tumor activity of 2-[(5-arylfuran-2-ylmethylene)-hydrazone]-thiazolidine-4-one

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

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Synthesis and in vitro Anti-tumor Activity of Some New Sebacoyl Chloride Based Heterocycles

Current Organic Synthesis ◽

10.2174/1570179413666161008200206 ◽

2017 ◽

Vol 14 (2) ◽

pp. 309-320 ◽

Cited By ~ 10

Author(s):

Islam Azab ◽

Nadia Elkanzi

Keyword(s):

Anti Tumor Activity

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Synthesis and Anti-Tumor Activity Evaluation of Novel 7-Fluoro-4-(1- Piperazinyl) Quinolines

Letters in Drug Design & Discovery ◽

10.2174/1570180815666180820131036 ◽

2019 ◽

Vol 16 (6) ◽

pp. 663-669

Author(s):

Dan Liu ◽

Aiqi Xue ◽

Zhixin Liu ◽

Yi Zhang ◽

Penghui Peng ◽

...

Keyword(s):

Spectral Analysis ◽

Cancer Therapy ◽

Carcinoma Cell ◽

A549 Cells ◽

Quinoline Derivatives ◽

Human Carcinoma ◽

Carcinoma Cell Lines ◽

Human Carcinoma Cell ◽

Anti Tumor Activity

Background: Three series of new 7-fluoro-4-(1-piperazinyl) quinolines (I1~I6, II1~II2 and IV1~IV4) were synthesized. Their anti-tumor activity was evaluated in vitro against three human carcinoma cell lines, namely SGC-7901 cells, BEL-7402 cells and A549 cells expressing high levels of EGFR by Methyl Thiazolyl Terazolium (MTT) assay. Methods: Three series of quinoline derivatives were synthesized, characterized and evaluated for their in vitro anti-tumor activities. Results and Discussion: Structures of the newly synthesized compounds were confirmed by spectral analysis. The preliminary bioassay indicated that compounds I1, I10 and II1 exhibited better anti-tumor activity than the rest of the target compounds and gefitinib against A549 cell based assay, which demonstrated that compounds I1, I10 and II1 are potential agents for cancer therapy. Results suggested that the substitutes on piperazinyl influenced anti-tumor activities remarkably. Conclusion: These results are useful for discovering more potent novel anti-tumor compounds and further studies are ongoing.

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