scholarly journals Relationships between vitamin D status and plasma levels of magnesium and parathormone in healthy young adults in Blida region (Algeria)

2020 ◽  
Vol 09 (02) ◽  
pp. 87-95
Author(s):  
◽  
Sidali RAMDANE ◽  
Abdelkader DJERMOUN ◽  
Larbi OUSSADOU ◽  
Keyword(s):  
Vitamin D ◽  
Active Form ◽  
Hypovitaminosis D ◽  
Significant Negative Correlation ◽  
Vitamin D Status ◽  
Positive Correlation ◽  
Hydroxyvitamin D ◽  
25 Hydroxy Vitamin D ◽  
The One ◽  
Plasma Magnesium

Introduction. Without magnesium, vitamin D cannot be converted to its biolo- gically active form, a relationship that is often overlooked. Objective. The aim of this study was to estimate the frequency of hypovitaminosis D and that of hypomagnese-mia on the one hand, and to analyze the relationship between vitamin D status, magnesium, and plasma parathormone on the other hand. Population and methods. A retrospective descriptive-analytical,and epidemiological study was conducted on a 112 apparently healthy young adult subjects. For this purpose, bioassays of 25-hydroxy-vitamin D, magnesium and plasma parathormone were performed. Results. The frequency of hypovitaminosis D (serum 25-hydroxyvitamin D  30ng/mL) represented 88.39%. Hypomagnesemia affeted 43.75% of the studied population. A highly significant positive correlation was noted between plasma magnesium levels and vitamin D status of the subjects (R= 0.849; P = 0.000), whereas, a very significant negative correlation was observed between magnesium and plasma parathormone levels (R=-0.92 ; P = 0.000). Conclusion. A high frequency of hypovitamin D, a significant frequency of hypomagne-semia, and a positive correlation between plasma magnesium and vitamin D status are observed. Magnesium level is a determining factor in the variation of serum calcidiol concentrations that should be considered in the assessment of vitamin D status.

scholarly journals Investigating the Role of Functional Polymorphism of Maternal and Neonatal Vitamin D Binding Protein in the Context of 25-Hydroxyvitamin D Cutoffs as Determinants of Maternal-Neonatal Vitamin D Status Profiles in a Sunny Mediterranean Region

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3082
Author(s):  
Spyridon N. Karras ◽  
Erdinç Dursun ◽  
Merve Alaylıoğlu ◽  
Duygu Gezen-Ak ◽  
Cedric Annweiler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mediterranean Region ◽  
Binding Protein ◽  
Hypovitaminosis D ◽  
Vitamin D Status ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
High Prevalence ◽  
25 Hydroxyvitamin D ◽  
Causative Effect

Recent results indicate that dysregulation of vitamin D-binding protein (VDBP) could be involved in the development of hypovitaminosis D, and it comprises a risk factor for adverse fetal, maternal and neonatal outcomes. Until recently, there was a paucity of results regarding the effect of maternal and neonatal VDBP polymorphisms on vitamin D status during pregnancy in the Mediterranean region, with a high prevalence of hypovitaminosis D. We aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphisms and different maternal and neonatal 25-hydroxyvitamin D (25(OH)D) cut-offs on maternal and neonatal vitamin D profile. Blood samples were obtained from a cohort of 66 mother–child pairs at birth. Our results revealed that: (i) Maternal VDBP polymorphisms do not affect neonatal vitamin D status at birth, in any given internationally adopted maternal or neonatal cut-off for 25(OH)D concentrations; (ii) neonatal VDBP polymorphisms are not implicated in the regulation of neonatal vitamin D status at birth; (iii) comparing the distributions of maternal VDBP polymorphisms and maternal 25(OH)D concentrations, with cut-offs at birth, revealed that mothers with a CC genotype for rs2298850 and a CC genotype for rs4588 tended to demonstrate higher 25(OH)D (≥75 nmol/L) during delivery (p = 0.05 and p = 0.04, respectively), after adjustments for biofactors that affect vitamin D equilibrium, including UVB, BMI and weeks of gestation. In conclusion, this study from Southern Europe indicates that maternal and neonatal VDBP polymorphisms do not affect neonatal vitamin D status at birth, whereas mothers with CC genotype for rs2298850 and CC genotype for rs4588 demonstrate higher 25(OH)D concentrations. Future larger studies are required to establish a causative effect of these specific polymorphisms in the attainment of an adequate (≥75 nmol/L) maternal vitamin D status during pregnancy.

scholarly journals Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels

2011 ◽  
Vol 106 (9) ◽  
pp. 1383-1389 ◽  
Author(s):  
R. K. Marwaha ◽  
N. Tandon ◽  
S. Chopra ◽  
N. Agarwal ◽  
M. K. Garg ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hypovitaminosis D ◽  
First Trimester ◽  
Strong Positive Correlation ◽  
Vitamin D Status ◽  
Second Trimester ◽  
Third Trimester ◽  
Indian Women ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

The present cross-sectional study was conducted to determine the vitamin D status of pregnant Indian women and their breast-fed infants. Subjects were recruited from the Department of Obstetrics, Armed Forces Clinic and Army Hospital (Research and Referral), Delhi. A total of 541 apparently healthy women with uncomplicated, single, intra-uterine gestation reporting in any trimester were consecutively recruited. Of these 541 women, 299 (first trimester, ninety-seven; second trimester, 125; third trimester, seventy-seven) were recruited in summer (April–October) and 242 (first trimester, fifty-nine, second trimester, ninety-three; third trimester, ninety) were recruited in winter (November–March) to study seasonal variations in vitamin D status. Clinical, dietary, biochemical and hormonal evaluations for the Ca–vitamin D–parathormone axis were performed. A subset of 342 mother–infant pairs was re-evaluated 6 weeks postpartum. Mean serum 25-hydroxyvitamin D (25(OH)D) of pregnant women was 23·2 (sd 12·2) nmol/l. Hypovitaminosis D (25(OH)D < 50 nmol/l) was observed in 96·3 % of the subjects. Serum 25(OH)D levels were significantly lower in winter in the second and third trimesters, while serum intact parathormone (iPTH) and alkaline phosphatase levels were significantly higher in winter in all three trimesters. A significant negative correlation was found between serum 25(OH)D and iPTH in mothers (r − 0·367, P = 0·0001) and infants (r − 0·56, P = 0·0001). A strong positive correlation was observed between 25(OH)D levels of mother–infant pairs (r 0·779, P = 0·0001). A high prevalence of hypovitaminosis D was observed in pregnancy, lactation and infancy with no significant inter-trimester differences in serum 25(OH)D levels.

scholarly journals Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2719 ◽  
Author(s):  
Li-Kai Wang ◽  
Kuo-Chuan Hung ◽  
Yao-Tsung Lin ◽  
Ying-Jen Chang ◽  
Zhi-Fu Wu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Hypovitaminosis D ◽  
Office Workers ◽  
Vitamin D Status ◽  
Total Calcium ◽  
Subtropical Region ◽  
Tertiary Referral Center ◽  
Hydroxyvitamin D

This study aimed at determining the prevalence and predictors of hypovitaminosis D (serum 25-hydroxyvitamin D < 30 ng/mL) among office workers in a subtropical region from an electronic hospital database. Totally, 2880 office workers aged 26–65 years who received health examinations with vitamin D status and total calcium concentrations at a tertiary referral center were retrospectively reviewed. Subjects were divided into groups according to genders, age (i.e., 26–35, 36–45, 46–55, 56–65), body-mass index (BMI) (i.e., obese BMI ≥ 30, overweight 25 ≤ BMI < 30, normal 20 ≤ BMI < 25, and underweight BMI < 20) and seasons (spring/winter vs. summer/autumn) for identifying the predictors of hypovitaminosis D. Corrected total calcium level <8.4 mg/dL is considered as hypocalcemia. Multivariate logistic regression demonstrated that females (AOR 2.33, (95% CI: 1.75, 3.09)), younger age (4.32 (2.98, 6.24), 2.82 (1.93, 4.12), 1.50 (1.03, 2.17)), and season (winter/spring) (1.55 (1.08, 2.22)) were predictors of hypovitaminosis D, whereas BMI was not in this study. Despite higher incidence of hypocalcemia in office workers with hypovitaminosis D (p < 0.001), there was no association between vitamin D status and corrected total calcium levels. A high prevalence (61.9%) of hypovitaminosis D among office workers in a subtropical region was found, highlighting the importance of this occupational health issue.

scholarly journals Vitamin D Status in a Rural Italian Population

Reports ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Ornella Morsilli ◽  
Raffaella Guerriero ◽  
Luigi Palmieri ◽  
Cinzia Lo Noce ◽  
Tanja Zeller ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critical Role ◽  
Central Italy ◽  
Hypovitaminosis D ◽  
Solar Irradiation ◽  
Italian Population ◽  
Vitamin D Status ◽  
Serum Samples ◽  
Younger Women ◽  
Hydroxyvitamin D

Vitamin D is known as an antirachitic factor, although it also plays a critical role in several nonskeletal diseases. In our study, we evaluated vitamin D status and sex, age and seasonal association in a general population cohort living in central Italy. Data from 1174 men and 2274 women aged 20–81 were analyzed, and stored serum samples were assayed for 25-hydroxyvitamin D (25(OH)D). Vitamin D was low in both sexes with values significantly lower in women than in men; furthermore, its deficiency was highly correlated with age. The younger men had just sufficient 25(OH)D levels (32.3 ng/mL ± 13.2), which decreased with increasing age. The younger women showed insufficient 25(OH)D levels (24.8 ng/mL ± 11.9) that, as with men, further decreased with increasing age. This study demonstrated that hypovitaminosis D may be a very frequent condition also in a rural central Italian area with remarkable solar irradiation throughout the year. Our data clearly indicated an evident seasonal trend: at the end of the winter, serum 25(OH)D levels of the examined cohort were below the official sufficient value for both adult sexes. Sufficient levels were just reached in summer for men and only at the end of summer for young women.

scholarly journals Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study

2009 ◽  
Vol 102 (6) ◽  
pp. 876-881 ◽  
Author(s):  
Valerie A. Holmes ◽  
Maria S. Barnes ◽  
H. Denis Alexander ◽  
Peter McFaul ◽  
Julie M. W. Wallace
Keyword(s):  
Vitamin D ◽  
Longitudinal Study ◽  
Pregnant Women ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Hydroxyvitamin D ◽  
Supplement Use

Maternal vitamin D insufficiency is associated with childhood rickets and longer-term problems including schizophrenia and type 1 diabetes. Whilst maternal vitamin D insufficiency is common in mothers with highly pigmented skin, little is known about vitamin D status of Caucasian pregnant women. The aim was to investigate vitamin D status in healthy Caucasian pregnant women and a group of age-matched non-pregnant controls living at 54–55°N. In a longitudinal study, plasma 25-hydroxyvitamin D (25(OH)D) was assessed in ninety-nine pregnant women at 12, 20 and 35 weeks of gestation, and in thirty-eight non-pregnant women sampled concurrently. Plasma 25(OH)D concentrations were lower in pregnant women compared to non-pregnant women (P < 0·0001). Of the pregnant women, 35, 44 and 16 % were classified as vitamin D deficient (25(OH)D < 25 nmol/l), and 96, 96 and 75 % were classified as vitamin D insufficient (25(OH)D < 50 nmol/l) at 12, 20 and 35 weeks gestation, respectively. Vitamin D status was higher in pregnant women who reported taking multivitamin supplements at 12 (P < 0·0001), 20 (P = 0·001) and 35 (P = 0·001) weeks gestation than in non-supplement users. Vitamin D insufficiency is evident in pregnant women living at 54–55°N. Women reporting use of vitamin D-containing supplements had higher vitamin D status, however, vitamin D insufficiency was still evident even in the face of supplement use. Given the potential consequences of hypovitaminosis D on health outcomes, vitamin D supplementation, perhaps at higher doses than currently available, is needed to improve maternal vitamin D nutriture.

scholarly journals Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: relation to nutrition and lifestyle

2007 ◽  
Vol 99 (4) ◽  
pp. 876-882 ◽  
Author(s):  
Seema Puri ◽  
Raman K. Marwaha ◽  
Neha Agarwal ◽  
Nikhil Tandon ◽  
Rashmi Agarwal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Hypovitaminosis D ◽  
Childhood And Adolescence ◽  
Vitamin D Status ◽  
Indian Children ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Socioeconomic Strata ◽  
Apparently Healthy

Forty to fifty per cent of skeletal mass, accumulated during childhood and adolescence, is influenced by sunlight exposure, physical activity, lifestyle, endocrine status, nutrition and gender. In view of scarce data on association of nutrition and lifestyle with hypovitaminosis D in Indian children and adolescents, an in-depth study on 3127 apparently healthy Delhi schoolgirls (6–18 years) from the lower (LSES, n 1477) and upper socioeconomic strata (USES, n 1650) was carried out. These girls were subjected to anthropometry and clinical examination for hypovitaminosis D. Girls randomly selected from the two strata (LSES, n 193; USES, n 211) underwent detailed lifestyle, dietary, biochemical and hormonal assessment. Clinical vitamin D deficiency was noted in 11·5 % girls (12·4 % LSES, 10·7 % USES). USES girls had significantly higher BMI than LSES counterparts. Prevalence of biochemical hypovitaminosis D (serum 25-hydroxyvitamin D < 50 nmol/l) was seen in 90·8 % of girls (89·6 % LSES, 91·9 % USES, NS). Mean intake of energy, protein, fat, Ca, vitamin D and milk/milk products was significantly higher in USES than LSES girls. Conversely, carbohydrate, fibre, phytate and cereal intakes were higher in LSES than USES girls. Physical activity and time spent outdoors was significantly higher in LSES girls (92·8 v. 64 %, P = 0·000). Significant correlation between serum 25-hydroxyvitamin D and estimated sun exposure (r 0·185, P = 0·001) and percentage body surface area exposed (r 0·146, P = 0·004) suggests that these lifestyle-related factors may contribute significantly to the vitamin D status of the apparently healthy schoolgirls. Hence, in the absence of vitamin D fortification of foods, diet alone appears to have an insignificant role.

Proposal and Validation of a Quick Question to Rate the Influence of Diet in Geriatric Epidemiological Studies on Vitamin D

2013 ◽  
Vol 83 (4) ◽  
pp. 254-258 ◽  
Author(s):  
Gaëlle Chevallereau ◽  
Xavier Gleyses ◽  
Laurène Roussel ◽  
Sarah Hamdan ◽  
Olivier Beauchet ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hypovitaminosis D ◽  
Epidemiological Studies ◽  
Hydroxyvitamin D ◽  
Background Diet ◽  
Simple Question ◽  
25 Hydroxy Vitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements ◽  
Exogenous Source

Background: Diet is a major exogenous source of vitamin D. The objective of this analysis was to determine whether the yes/no answer to a simple question exploring diet (“Do you eat fatty fish at least once a week and/or eggs several times per week?”) could be associated with serum 25-hydroxy-vitamin D status among 261 older in- and outpatients (mean ± standard deviation, 83.5 ± 8.1 years). Methods: Two groups were distinguished based on the binary yes/no answer. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D ≤ 75 nmol/L. Results: More participants with hypovitaminosis D answered “No” to the question on diet compared to their counterparts (p = 0.002). Answering “No” was associated with hypovitaminosis D (OR = 3.22, p = 0.001) after adjustment for potential confounders, with a positive predictive value = 79 %. Conclusion: A simple dietary question may identify older patients with hypovitaminosis D who should receive vitamin D supplements.

Serum 25-Hydroxyvitamin D and the risk of breast cancer in women from Southern Morocco: A case-control study

2022 ◽  
pp. 1-8
Author(s):  
Abdellah Moukal ◽  
Abdallah El Farouqi ◽  
Mohamed Aghrouch ◽  
Smail Chadli ◽  
Abderrahmane Zekhnini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Odds Ratio ◽  
Hypovitaminosis D ◽  
Anthropometric Parameters ◽  
Luminal B ◽  
Hydroxyvitamin D ◽  
25 Hydroxy Vitamin D ◽  
25 Hydroxyvitamin D ◽  
Moroccan Women

OBJECTIVES: Assessing Vitamin-D status and checking if low serum 25(OH)D is a factor in breast cancer (BC) for Southern Moroccan women. MATERIALS/METHODS: Study conducted in Morocco about women with BC (n = 90) and controls (n = 90). 25-hydroxy-vitamin-D Biological analyzes executed during the first consultation. Social data and anthropometric parameters were collected for all participants. RESULTS: These women constituted 67.78 % for the cases and 85.6% for the controls. The average age was 48.72±9.71 (cases) and 46.40±12.52 (controls). We found that 53.33% of cases and 40% of controls were postmenopausal and that hypovitaminosis-D affected 80 and 64.4% of cases and controls, respectively. Statistical analysis showed that hypovitaminosis-D was a significative risk factor for BC in Southern Moroccan women. The Odds Ratio was of 5 (p <  0.0001). The BC subtypes had Odds Ratios greater than 1. The highest value was obtained with Luminal B subtype (Odds ratio = 6.25; p = 0.0007). CONCLUSION: This study reinforces the evidence implicating hypovitaminosis-D among modifiable risk factors for BC. Further studies are needed to assess the extent of hypovitaminosis-D in Moroccan women with BC.

scholarly journals Vitamin D status in healthy Romanian caregivers and risk of respiratory infections

2012 ◽  
Vol 15 (11) ◽  
pp. 2157-2162 ◽  
Author(s):  
Alina C Porojnicu ◽  
Ruxandra Moroti-Constantinescu ◽  
Andrei Laslau ◽  
Zoya Lagunova ◽  
Arne Dahlback ◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Infections ◽  
Sun Exposure ◽  
Population Level ◽  
Significant Negative Correlation ◽  
Healthy Population ◽  
Upper Respiratory Tract ◽  
Vitamin D Status ◽  
Hospital Employees ◽  
Hydroxyvitamin D

AbstractObjectivesTo investigate the vitamin D status during winter of a healthy population of hospital employees and to assess the correlation between vitamin D status and risk of infections in the upper respiratory tract.DesignOne hundred and ten healthy volunteers answered a questionnaire on their solar exposure habits and vitamin D intake and delivered one blood sample for quantification of vitamin D level (serum 25-hydroxyvitamin D (25(OH)D) concentration) during December 2007–January 2008. At the end of the winter we screened for the occurrence of respiratory infections and sought associations with vitamin D status.SettingBucharest, Romania, 45°N.SubjectsOne hundred and ten healthy hospital employees.ResultsEighty per cent of participants were vitamin D deficient (25(OH)D level below 50 nmol/l). The main determinant of serum 25(OH)D was sun exposure during the summer previous to the study (P = 0·02 in multivariate analysis). Intake of vitamin D, BMI and age played no significant role for the level of 25(OH)D. Overall we found a non-significant negative correlation between 25(OH)D level and new cases of infection (Spearman correlation coefficient of −0·12, P = 0·2).ConclusionsVitamin D status is alarmingly poor in active, relatively young women residing in Romania. If our results are reproduced by other investigations, action to improve vitamin D status at the population level is necessary. We were not able to show a statistically significant relationship between vitamin D status and infection risk in our material.

scholarly journals Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency

2013 ◽  
Vol 169 (6) ◽  
pp. 767-772 ◽  
Author(s):  
Pietro Ameri ◽  
Andrea Giusti ◽  
Mara Boschetti ◽  
Marta Bovio ◽  
Claudia Teti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gh Deficiency ◽  
Hormone Replacement ◽  
Positive Association ◽  
Significant Negative Correlation ◽  
Vitamin D Status ◽  
Significant Positive Association ◽  
Potential Implication ◽  
Hydroxyvitamin D ◽  
Before And After

ObjectivesPrevious studies suggested that vitamin D modulates circulating IGF1. We investigated this effect in adults and its clinical relevance in the management of GH deficiency (GHD).Design and methodsIGF1 levels were prospectively measured before and after 12 weeks of treatment with oral vitamin D3(5000 or 7000 IU/week) vs no intervention in 39 subjects 61.9±7.9 years old. The frequency of IGF1 values ≥50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4±16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured.ResultsTreatment with 5000 and 7000 IU vitamin D3/week significantly raised 25(OH)D by 12.7±8.4 and 13.1±6.5 ng/ml respectively (bothP<0.001 vs baseline). In the 7000 IU group, IGF1 levels also significantly increased by 31.3±36.7 ng/ml (P=0.01). Neither 25(OH)D nor IGF1 significantly varied in controls. IGF1 was ≥50th percentile more frequently in GHD patients with 25(OH)D levels ≥15 than <15 ng/ml (65.9 vs 40.0%,P<0.05). Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between ≥15 ng/ml 25(OH)D and IGF1 ≥50th percentile (OR 4.4, 95% CI 1.0–18.8,P<0.05). A significant negative correlation between 25(OH)D concentrations and rhGH dose was found after correcting for age and IGF1 (β−0.042,P<0.01), but not after further adjusting for sex, thyroid, adrenal or gonadal replacement, and season (β−0.037,P=0.06).ConclusionsVitamin D increases circulating IGF1 in adults. As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD.

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