scholarly journals Kualitas diet berhubungan dengan defisiensi besi pada atlet remaja putri

2021 ◽  
Vol 6 (1) ◽  
pp. 48
Author(s):  
Fillah Fithra Dieny ◽  
Ria Fitri Setyaningsih ◽  
A Fahmy Arif Tsani

An adolescent female athlete has a high risk of suffering iron deficiency. Low-quality diets reflect a lack of variety, adequacy, balance, and moderation, but these have not been associated with iron deficiency. This study aimed to analyze the relationship of diet quality with iron deficiency. Methods, the research was conducted at the Student Center for Education and Sports Training Central Java, the Salatiga athletic club, the Semarang State University athletic, and the swimming club. The subjects were 82 female athletes aged 13-21 years who were selected by purposive sampling. The variables of this study were diet quality and iron deficiency. The diet quality measured by assessing food consumption used the Semi-Quantitative Food Frequency Questionnaire and then the diet quality score calculated by Diet Quality Index-International. Iron deficiency measured based on serum ferritin level. The bivariate was analyzed by the Rank Spearman test. Results, as many as 17,1% of subjects suffering iron deficiency and 95,1% of subjects had low diet quality. Diet quality and its component; Variety, adequacy, moderation, and overall balance were associated with serum ferritin (p<0,05). Energy, protein, iron, fiber adequacy also related to serum ferritin, but vitamin C adequacy was not related to this. In conclusion, low-quality diets are associated with iron deficiency in female athletes.

PEDIATRICS ◽  
1983 ◽  
Vol 72 (2) ◽  
pp. 214-219
Author(s):  
Ray Yip ◽  
Samuel Schwartz ◽  
Amos S. Deinard

Elevation of erythrocyte protoporphyrin (EP) level is one of the consequences of iron deficiency. As the EP test has been established to be a screening test for lead poisoning, the screening capability of the EP test for iron deficiency was investigated. A total of 4,160 children between ages 6 months to 12 years had EP determined together with serum ferritin and hematocrit. Comparing the relationship of EP to serum ferritin and using a serum ferritin value ≤15 µg/L as the criterion of iron deficiency, the optimal cutoff limit for the EP test appears to be 35 µg/dL of whole blood. At this level, 88% of the subjects with low levels of serum ferritin can be detected (sensitivity), in contrast to the 53% detected at a higher cutoff value (≥50 µg/dL) used to screen for lead toxicity, or to the 59% detected by age-related hematocrit value. At an EP screening level of 35 µg/dL of whole blood, 90% of the subjects with normal serum ferritin level are correctly determined to be screen negative (specificity). The predictive value of low levels of serum ferritin for all subjects above screening level is 38%. In general, an elevated EP level, by itself, represents inadequate iron supply for hematopoiesis and signals iron deficiency regardless of whether the serum ferritin value is below the diagnostic level or not. A trial course of orally administered iron is suggested for children who are found to have an elevated EP value, with an increase in hemoglobin or hematocrit value serving, retrospectively, as confirmation of prior iron deficiency.


2020 ◽  
Vol 10 (3) ◽  
pp. 182-186
Author(s):  
Md Abdul Baki ◽  
Shahida Akhter ◽  
Jebun Nahar ◽  
Fauzia Mohsin ◽  
Shareen Khan

Background: Fetal iron stores are affected by maternal diabetes and it is lower at birth in infants of diabetic mothers (IDMs). Risks for developing iron deficiency and neurocognitive impairment are reported in IDMs. This study was done to assess serum ferritin and red cell indices in IDMs and to compare the values with infants born to mothers without diabetes mellitus. Methods: This cross-sectional study was carried out at BIRDEM General Hospital from March to October, 2018. Total 102 full term neonates were included in this study. Among them 70 neonates were IDMs and 32 were infants born to mother without diabetes mellitus. Serum ferritin and red cell indices like hemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW) were measured within 48 hours of birth. Comparison of red cell indices and serum ferritin level were done between IDMs and infants of non-diabetes mothers. Statistical analysis was performed by using Epi info, and p value of <0.05 was considered statistically significant. Results: IDMs had significantly higher value of Hb% (19.00 vs 17.47 g/dl), PCV (57.60 vs 52.67 %) and RDW (20.09 vs17.77 %) than infant of non-diabetic mother (p <0.05). But there was no significant difference regarding the values of MCV, MCH and MCHC between IDMs and infants of non-diabetic mothers (p >0.05). Serum ferritin level was found significantly low in IDMs (94.51 vs 307.50 ng/ml, p <0.001). Conclusion: Iron stores of IDMs were found significantly lower at birth despite higher hemoglobin content, as indicated by lower serum ferritin level. Further studies and long-term follow up are needed to determine whether these infants are at risk for developing iron deficiency anemia or iron-deficient neurocognitive disorder Birdem Med J 2020; 10(3): 182-186


Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3706-3706
Author(s):  
Ernest Beutler ◽  
Carol West

Abstract The fact that the average hemoglobin concentration (Hb) of AA is lower than that of whites has been documented extensively. Several investigations have shown that this difference of approximately 0.8 g/dL is due neither to iron deficiency nor to socioeconomic status. Its cause remains unknown. We compared the Hb of 1,493 AA and 31,029 white anonymized patients attending a Health Appraisal Clinic and confirmed the known difference in Hb, both for females and males (0.79 and 0.47 g/dL) respectively. The difference persisted when a subset of the subjects were paired by age and narrowed slightly in females when those with serum ferritin levels of <10 ng/ml or transferrin saturations of <16% were excluded (difference in females 0.59 g/dL; males 0.47). We determined the α-thalassemia −3.7 genotype of 298 AA. The gene frequency was found to be 0.17, and the distribution of genotypes fit the Hardy-Weinberg equilibrium. However, in a sample of 155 white subjects only one α-thalassemia allele was found (gene frequency=0.003). Among the AA subjects, the Hb and MCV values were lower in homozygotes (−a/−a) and heterozygotes (aa/−a) for α-thalassemia than in the aa/aa subjects. The table presents data for AA and white subjects after excluding all who did not have a documented serum ferritin level of >9 ng/ml and a transferrin saturation of >16%. Excluding subjects with sickle trait had no effect. Ethnic Group Genotype n Mean Hb SE Hb Mean MCV SE MCV −a/−a 3 11.87 0.418 72.23 2.32 F AA aa/−a 20 12.69 0.202 85.22 0.86 aa/aa 65 13.17 0.127 90.43 0.61 White 2917 13.60 0.016 90.85 0.07 −a/−a 2 13.85 0.550 83.05 1.65 M AA aa/−a 36 14.37 0.161 85.81 0.78 aa/aa 86 14.75 0.123 89.78 0.53 White 5335 15.09 0.013 90.35 0.06 As shown in the table, the average Hb of non-iron deficient AA females and males who had 4 normal α loci (aa/aa) was 0.43 and 0.34 g/dL lower respectively than those of whites, the difference being significant with p<0.01. We conclude that one cause of the lower Hb of AA compared to white subjects is the high prevalence of α-thalassemia in the AA population, but that it accounts for only about one-quarter of the difference after iron deficiency has been excluded. There are other, as yet undefined, causes that play a role. These may include the lower ATP (Biochem. Genet.1:25, 1967) and higher 2,3 BPG (Transfusion18:108, 1978) levels that have been documented in the red cells of AA subjects.


2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yaşar Doğan ◽  
Tülay Erkan ◽  
Zerrin Önal ◽  
Merve Usta ◽  
Gülen Doğusoy ◽  
...  

Aim. To determine gastric tissue lactoferrin (Lf) levels ofHelicobacter pylori-(Hp-) positive and -negative patients and its effect on anemia.Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.Results. The study included 64 cases (average: years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were % and , respectively. Hp-negative cases showed significantly different values of % and , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were /dL and /mL, but these were comparable with Hp-negative cases (/dL and /mL).Conclusions.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.


Author(s):  
Naama W. Constantini ◽  
Alon Eliakim ◽  
Levana Zigel ◽  
Michal Yaaron ◽  
Bareket Falk

Much attention has focused on the nutrition and hematological profile of female athletes, especially gymnasts. The few studies on iron status of male adolescent athletes found a low incidence of iron deficiency. The present study investigated the iron status of male and female gymnasts (G) and compared it with athletes of other sports. Subjects were 68 elite athletes (43 M, 25 F) ages 12-18, of four sports: gymnasts (11 M, 12 F), swimmers (11 M, 6 F), tennis players (10 M, 4 F), and table tennis players (11 M, 3 F). All lived in the national center for gifted athletes, trained over 25 hr a week, ate in the same dining room, and shared a similar lifestyle. Mean levels of hemoglobin (Hb), red blood cell indexes, serum ferritin, serum iron, and transferrin were measured in venous blood. There was no difference in mean Rb among gymnasts (G) and nongymnasts (NG). However, Hb was less than 14 g/dL in 45% of M G vs. only 25% in NG, and less than 13 g/dL in 25% of premenarcheal FG vs. 15% in NG. Low transferrin saturation (< 20%) was detected in 18% of M G and 25% of FG vs. 6% and 8% in male and female NG, respectively (p < .05). The percentage of males suffering from low ferritin level (< 20 ng/ml) was twice as high in G (36%) vs. NG (19%), and about 30% in all females. In summary, iron stores were consistently lower in M G vs. NG. Adolescent athletes of both genders, G in particular, are prone to nonanemic iron deficiency, which might compromise their health and athletic performance.


2013 ◽  
Vol 5 (1) ◽  
pp. 5-11
Author(s):  
S Akhter ◽  
ZU Nahar ◽  
S Parvin ◽  
A Alam ◽  
S Sharmin ◽  
...  

Iron deficiency is the most important but preventable nutritional problem in Bangladesh. Thyroid peroxidase, an iron containing enzyme, is essential for initial two steps of thyroid hormone synthesis which is a component of tissue iron. Tissue iron diminishes early in the course of iron deficiency. So thyroid hormone level may be altered in iron deficient patients. This case-control study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) from July 2006 to June 2007. This study was done to find out the changes of thyroid hormonal activity in iron deficiency.In this study 72 subjects were selected from the out-patient department of the hospital. Patients with low serum ferritin level <12 mgm/L were selected as cases (n=36) and healthy persons with normal serum ferritin level were taken as controls. Serum ferritin, thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were measured in all study subjects. Values were expressed as mean ± SD. Unpaired 't' test and Pearson's correlation test were performed to see the level of significance and p value <0.05 was taken as significant. Serum ferritin level in cases and controls were 6.78±4.05 mgm/L and 79.04±28.08 mgm/L respectively which showed significant difference (P<0.0001).Serum TSH concentration in cases and controls were 3.32±1.54 mIU/L and 1.89±0.86 mIU/L respectively. Serum FT4 concentration in cases and controls were 11.66±1.77 pmol/L and 13/10±1.36 pmol/L respectively and that of FT3 were 3.00±0.68 and 3.31±0.61 pmol/L respectively. All showed significant difference between groups.Serum ferritin and Serum TSH showed significant negative correlation in controls whereas in cases they showed negative correlation which was not statistically significant.Both serum FT4 and FT3 revealed positive correlation with serum ferritin but that too was not significant statistically.Though the study failed to show any significant positive correlation between serum ferritin and thyroid hormones, lower level of thyroid status in iron deficient patients suggest that it could be a reflection of disturbed activities of iron dependent enzymes such as thyroid peroxidase that impairs thyroid hormone synthesis. However, a large scale study is recommeded to establish the fact.This study showed that there was significant difference in thyroid hormonal status between iron deficient patients and normal healthy persons. Therefore it can be concluded that iron deficiency may impair normal thyroid hormone status. DOI: http://dx.doi.org/10.3329/bjmb.v5i1.13424 Bangladesh J Med Biochem 2012; 5(1): 5-11


2013 ◽  
Vol 3 (1) ◽  
pp. 5-10
Author(s):  
Wasim Md. Mohosinul Haque ◽  
Arif Mahmud ◽  
Muhammad Abdur Rahmin ◽  
Jesmin Jahan ◽  
Sarker Mohammad Sajjad ◽  
...  

Objective: To evaluate the iron status among patients with diabetes mellitus and CKD stage 5, who have not started dialysis yet. Methodology: This cross-sectional study was carried on a total of 50 adult diabetic patients with stage 5 CKD, in the Department of Nephrology, BIRDEM General Hospital, Dhaka over 6 months. Results: Total number of patients was 50. Sixty two percent were male and 38% were female. Mean age was 55.22 (range 33-75) years. Mean± SD hemoglobin and ferritin levels were 7.61±2.54 mg/dl and 155.22±92.32 ng/ml respectively. Seventy percent of the study subjects had haemoglobin level d” 9 mg/dl. In 48% of the study subjects, ferritin level was less than 100ng/ml. Fourty six percent of the study subjects had TSAT level below 20%. Haemoglobin, serum ferritin and TSAT level in the study subjects had negative relationship with duration of CKD. Haemoglobin and serum ferritin levels were positively correlated with eGFR of the study population. TIBC level had negative relationship with haemoglobin level which was statistically significant. Serum iron, ferritin and TSAT level in the study subjects were positively correlated with haemoglobin level. Relationship of haemoglobin with serum iron and TSAT level was statistically significant. Statistical analysis showed relationship between eGFR with haemoglobin and serum ferritin level was significant (P<0.05). Conclusion: Most of the diabetic CKD stage 5 patients had reduced hemoglobin level and iron deficiency is one of the contributory factors and TSAT is the better indicator for iron deficiency than serum iron, TIBC and ferritin level. Birdem Med J 2013; 3(1): 5-10 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17120


2021 ◽  
Vol 44 (1) ◽  
pp. 1-10
Author(s):  
Fillah Fithra Dieny ◽  
Deny Yudi Fitranti ◽  
Firdananda Fikri Jauharany ◽  
A Fahmy Arif Tsani

The female athlete triad (FAT) is a syndrome that occurs in female athletes who have a combination of 3 related conditions and are associated with sports. The aimed of this study to analyze the relationship between iron deficiency and the state of the female athlete triad (FAT) in female athletes. The design of this study was cross sectional with 80 subjects of female athletes aged 12-18 years from various sports, who were taken by simple random sampling. The research was conducted at the Central Java Student Center for Education and Sports Training (BPPLOP). Bivariate analysis was performed using the Spearman test. Based on Ferritin, as many as 15 subjects (18.25%) had iron deficiency anemia, and FAT syndrome was not found in the subjects, however, when each sign was seen, 20 percent were classified as polimenorrhea and oligomenorrhea, and 37.5 percent experienced eating disorders. There were a significant relationship between iron deficiency based on serum ferritin (p = 0.015; r = 0.273) and Hb levels (p = 0.002; r = 0.337) with the component of athlete's bone density. However, iron deficiency (based on serum Ferritin and Hb levels) did not show a significant association with menstrual cycle disorders and eating disorders (p 0.05). Female Athlete Triad has not been found among subjects, but athletes have experienced eating behavior disorders, menstrual cycle disorders and the risk of low bone density. Iron deficiency is associated with decreased bone density in young female athletes. ABSTRAK Female athlete triad (FAT) merupakan suatu syndrom yang terjadi pada atlet wanita yang memiliki kombinasi dari 3 kondisi yang saling berkaitan, dan berhubungan dengan olahraga. Tujuan penelitian untuk menganalisis hubungan defisiensi besi dengan keadaan female athelete triad (FAT) pada atlet remaja putri. Desain penelitian ini adalah cross-sectional dengan 80 subjek atlet putri berusia 12-18 tahun dari berbagai cabang olahraga yang diambil secara simple random sampling. Penelitian dilakukan di Balai Pemusatan Pendidikan dan Latihan Olahraga Pelajar (BPPLOP) Jateng. Analisis univariat untuk mendeskripsikan data berupa distribusi dan persentase. Analisis bivariat dilakukan menggunakan uji Spearman. Berdasarkan data serum ferritin, sebanyak 15 subjek (18,25%) mengalami anemia defisiensi besi, namun belum ditemukan kejadian FAT pada subjek, tetapi bila dilihat masing masing tanda sebanyak 20 persen tergolong polimenorea dan oligomenorea, serta 37,5 persen mengalami gangguan perilaku makan. Ada hubungan yang signifikan antara defisiensi besi berdasarkan serum ferritin (p=0,015; r=0,273) dan kadar Hb (p=0,002; r=0,337) dengan komponen kepadatan tulang atlet. Namun defisiensi besi (bedasarkan serum Ferritin dan Kadar Hb) tidak menunjukkan hubungan yang signifikan dengan gangguan siklus menstruasi dan gangguan perilaku makan (p0,05). FAT belum ditemukan pada atlet remaja putri, namun atlet sudah ada yang mengalami gangguan perilaku makan, gangguan siklus menstruasi dan risiko kepadatan tulang rendah. Defisiensi besi berhubungan dengan menurunnya kepadatan tulang atlet remaja putri.Kata kunci: atlet; remaja putri; defisiensi besi; female athlete triad (FAT) 


Blood ◽  
1977 ◽  
Vol 50 (3) ◽  
pp. 441-447 ◽  
Author(s):  
CA Finch ◽  
JD Cook ◽  
RF Labbe ◽  
M Culala

Serum ferritin was measured in 2982 blood donors. First-time male donors had a geometric mean of 127 microgram/liter and female donors 46 microgram/liter. While values were essentially constant in the women between the ages of 18 and 45, there was a rapid increase in the men between 18 and 30 years of age consistent with the establishment of iron stores during that time. Blood donation was associated with a decrease in serum ferritin. One unit per year, equivalent to an increased requirement of 0.65 mg/day, halved the serum ferritin level in the male. More frequent donations were associated with further decreases. From the data obtained it would appear that male donors, while depleting their iron stores, were able to donate 2–3 U/yr without an appreciable incidence of iron deficiency. Women could donate only about half that amount, and more frequent donations were associated with a high incidence of iron deficiency and donor dropout. These data have provided information on the effect of graded amounts of iron loss through bleeding on iron balance.


Author(s):  
Abdulateef O. Kareem ◽  
Akinsegun A. Akinbami ◽  
Ebele I. Uche ◽  
Aishatu M. Suleiman ◽  
Rafah A. Bamiro ◽  
...  

<p class="abstract"><strong>Background:</strong> The elderly have limited regenerative abilities thus predisposing them to various diseases. Measuring both serum ferritin and transferrin serve as biomarkers of iron deficiency. This study, using enzyme-linked immunosorbent assay (ELISA) determined the serum levels of ferritin and transferrin in the elderly. Full blood count was also done and correlated with serum ferritin and transferrin levels of every participant.</p><p class="abstract"><strong>Methods:</strong> This was a cross-sectional study at the Geriatric Clinic of Lagos State University Teaching Hospital (LASUTH). Following receipt of written consents from ninety (90) elderly participants, venous samples were drawn for full blood count (FBC) and samples for serum ferritin and transferrin ELISA assay collected and stored at -40<sup>o</sup>C until the required sample size was obtained. Data were analyzed using SPSS version 23.0 (Statistical Package for Social Sciences, Inc., Chicago, Ill). The Pearson chi-square test was used for statistical analysis. P value was considered to be statistically significant when &lt;0.05.  </p><p class="abstract"><strong>Results:</strong> Participants consisted of 50 (55.6%) females and 40 (44.4%) males. The mean age of all participants was 71.31±7.38 years. The Majority, 90% (36 of 40) of the males had haemoglobin values lower than 13 gm/dl, while 66% (33 of 50) of females had haemoglobin values lower than 12 gm/dl. The mean ferritin concentration of all participants was 196.19 ±121.21ng/ml. The overall mean serum transferrin was 0.187±0.157 ng/ml with a minimum of 0.03 ng/ml and a maximum of 1.18 ng/ml.</p><p class="abstract"><strong>Conclusions:</strong> Anaemia in the elderly is very common using the World Health Organization (WHO) haemoglobin cut-off values, however, iron deficiency anaemia prevalence is low.</p>


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