Analysis of the electrodynamic model of a biologically active point of animal skin

В.В. Гузенко; В.В. Семенець; Т.В. Носова; М.Л. Лисиченко; Н.Г. Косуліна

doi:10.30837/rt.2020.2.201.21

Long-term results of laser therapy in patients with bronchial asthma and chronic obstructive bronchitis

Kazan medical journal ◽

10.17816/kazmj70717 ◽

1986 ◽

Vol 67 (5) ◽

pp. 379-380

Author(s):

N. I. Maksimov

Keyword(s):

Bronchial Asthma ◽

Biologically Active ◽

Long Term Results ◽

Chronic Obstructive ◽

Active Point ◽

Chronic Obstructive Bronchitis ◽

Helium Neon Laser ◽

Irradiation Power ◽

Helium Neon

We performed a course of treatment with the helium-neon laser L G-75 in the conditions of a polyclinic for patients with bronchial asthma (170 persons) and chronic obstructive bronchitis (90). Exposure to the laser beam was made taking into account the experience of reflexotherapy. Time of exposure to each biologically active point was 10 s with irradiation power of 25 mW (course - 15-20 procedures).

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Histological structure of the human biologically active point (BAP) ST36

10.15547/tjs.2015.s.02.015 ◽

2015 ◽

Vol 13 (Suppl.2) ◽

pp. 67-69

Author(s):

N. Dimitrov ◽

◽

D. Sivrev ◽

D. Atanasova ◽

◽

...

Keyword(s):

Biologically Active ◽

Histological Structure ◽

Active Point

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Evaluation of the effectiveness of pharmacotherapy for brain and heart diseases by monitoring the effects of drugs

Research Results in Pharmacology ◽

10.3897/rrpharmacology.6.52300 ◽

2020 ◽

Vol 6 (2) ◽

pp. 43-55

Author(s):

Valeriya I. Kharina ◽

Tatiyana A. Berezhnova

Keyword(s):

Ischemic Stroke ◽

Real Time ◽

High Probability ◽

Heart Diseases ◽

Biologically Active ◽

Active Point ◽

Cerebrovascular Events ◽

Invasive Method ◽

Stroke Type ◽

Doxorubicin Cardiomyopathy

Introduction: The study aims at analyzing the possibility of using a method of monitoring the action of drugs in real-time to assess the effectiveness of pharmacotherapy for brain and heart lesions. Materials and methods: To assess the effect of drugs in the experiment and in the clinic, the temperature difference between the biologically active point and the intact skin zone was recorded every second for 2 minutes. The work involved experimental and clinical parts. The experimental study was performed on 81 rabbits. In the experiment, the effect of Meldonium was evaluated when treating doxorubicin cardiomyopathy and the effect of Cortexin – when treating experimental brain ischemia. The clinical testing of the method involved 10 healthy volunteers and 20 patients of both sexes, diagnosed with acute cerebrovascular events of the ischemic-stroke type. Results and discussions: An increase of some indicators of differential thermometry of the biologically active point by 60% or more on the 7th day of the treatment concerning the values obtained before the treatment is indicative of a high probability of pronounced positive dynamics in the treatment of doxorubicin cardiomyopathy. If on the 7th day of the treatment, some indicators of differential thermometry of biologically active point С7 to exceed by 20% or more the similar indicators before the treatment, a high probability of pronounced positive dynamics in the treatment of ischemic stroke can be inferred. Conclusion: A safe, non-invasive method for monitoring the effects of drugs in real-time, which does not require any special training of a doctor, has been developed.

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Using a model of biologically active points and fractal structure of a bioobject for the implementation of the sensors and dosimetry control of pathogenic radiation

Journal of New Medical Technologies eJournal ◽

10.12737/7351 ◽

2014 ◽

Vol 8 (1) ◽

pp. 0-0

Author(s):

Ларкин ◽

E. Larkin ◽

Яшин ◽

S. Yashin

Keyword(s):

Fractal Geometry ◽

Electromagnetic Waves ◽

Fractal Structure ◽

Biologically Active ◽

Practical Implementation ◽

Significant Information ◽

Active Point ◽

Electro Magnetic ◽

Biological Environment ◽

Biologically Active Points

The authors present the relationship between the fractal geometry and biophysics, in particular the pathogenic effects of electromagnetic radiation on personnel of enterprises and institutions. A model of biologically active points of the skin of the person, which is the most adequate for the technical implementation of the sensors in the system for monitoring and dosimetry, is considered in this paper. It is shown that the fractal structure of a bioobject explains many of the natural science aspects of the physics, the fractal geometry and describes many processes in the biosystem, including pathological. It is established that due to the multiplicity of electro-magnetic resonances in biological systems, the pathogenicity of human exposure in the risk group of staff must be taken into account in the systems of monitoring and dosimetry as a spreading of pathogenic electromagnetic waves in a fractal biological environment. The results of this research of fractal properties of biological objects allow to conclude that the human body perceives pathogenic radiation in all spectra, as it has developed fractal structure with multiple biological resonances. This research shows that the modified model of the Hodgkin - Huxley for the description of electromagnetic processes in the field of biologically active point is the most significant information. For the practical implementation of the model on the computer was produced simplification. This model is recommended as a basic reference for the technical design of the sensors monitoring and dosimetry affecting staff pathogenic radiation.

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Characterization of photosystem II with the atomic-force microscope

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100130365 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1146-1147

Author(s):

Kathleen M. Marr ◽

Mary K. Lyon

Keyword(s):

Photosystem Ii ◽

Atomic Force Microscope ◽

Three Dimensional ◽

Biologically Active ◽

Atomic Force ◽

Freeze Etching ◽

Image Averaging ◽

Oxygen Evolving ◽

Averaging Techniques

Photosystem II (PSII) is different from all other reaction centers in that it splits water to evolve oxygen and hydrogen ions. This unique ability to evolve oxygen is partly due to three oxygen evolving polypeptides (OEPs) associated with the PSII complex. Freeze etching on grana derived insideout membranes revealed that the OEPs contribute to the observed tetrameric nature of the PSIl particle; when the OEPs are removed, a distinct dimer emerges. Thus, the surface of the PSII complex changes dramatically upon removal of these polypeptides. The atomic force microscope (AFM) is ideal for examining surface topography. The instrument provides a topographical view of individual PSII complexes, giving relatively high resolution three-dimensional information without image averaging techniques. In addition, the use of a fluid cell allows a biologically active sample to be maintained under fully hydrated and physiologically buffered conditions. The OEPs associated with PSII may be sequentially removed, thereby changing the surface of the complex by one polypeptide at a time.

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Depletion and Reconstitution of Active E. Coli Ribosomes

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100116826 ◽

1975 ◽

Vol 33 ◽

pp. 640-641

Author(s):

M. Boublik ◽

W. Hellmann ◽

F. Jenkins

Keyword(s):

Protein Biosynthesis ◽

Large Subunit ◽

High Resolution Electron Microscopy ◽

Small Subunit ◽

Structure And Function ◽

Biologically Active ◽

Biological Macromolecules ◽

E Coli ◽

Resolution Electron ◽

And Function

Correlations between structure and function of biological macromolecules have been studied intensively for many years, mostly by indirect methods. High resolution electron microscopy is a unique tool which can provide such information directly by comparing the conformation of biopolymers in their biologically active and inactive state. We have correlated the structure and function of ribosomes, ribonucleoprotein particles which are the site of protein biosynthesis. 70S E. coli ribosomes, used in this experiment, are composed of two subunits - large (50S) and small (30S). The large subunit consists of 34 proteins and two different ribonucleic acid molecules. The small subunit contains 21 proteins and one RNA molecule. All proteins (with the exception of L7 and L12) are present in one copy per ribosome.This study deals with the changes in the fine structure of E. coli ribosomes depleted of proteins L7 and L12. These proteins are unique in many aspects.

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Fractionation of the Biologically Active Large Molecular Components of Human Gastric Content

Gastroenterology ◽

10.1016/s0016-5085(19)35388-0 ◽

1959 ◽

Vol 37 (4) ◽

pp. 439-444 ◽

Cited By ~ 1

Author(s):

Ranwel Caputto ◽

William O. Smith ◽

Jordan Tang ◽

Raul E. Trucco ◽

Walter Joel ◽

...

Keyword(s):

Gastric Content ◽

Biologically Active ◽

Molecular Components

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Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000574 ◽

2020 ◽

Vol 90 (5-6) ◽

pp. 411-416 ◽

Cited By ~ 2

Author(s):

Carina Kolot ◽

Ana Rodriguez-Mateos ◽

Rodrigo Feliciano ◽

Katharina Bottermann ◽

Wilhelm Stahl

Keyword(s):

Plasma Levels ◽

Average Concentration ◽

Biologically Active ◽

Thiol Groups ◽

Structural Element ◽

Active Molecule ◽

Reactive Center ◽

Average Maximum ◽

Alpha Beta ◽

Cherry Tomatoes

Abstract. Chalcones are a type of flavonoids characterized by an α-β unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system. Naringenin chalcone is abundant in the diet but little is known about its bioavailability. In this work, the bioavailability of naringenin chalcone from tomatoes was investigated in a group of healthy men (n=10). After ingestion of 600 grams of tomatoes providing a single dose of 17.3 mg naringenin chalcone, 0.2 mg of naringenin, and 195 mg naringin plasma levels of free and conjugated naringenin and naringenin chalcone (glucuronide and sulfate) were analyzed by UHPLC-QTOF-MS at 0.5, 1, 3, and 6 h post-consumption. Plasma levels of conjugated naringenin increased to about 12 nmol/L with a maximum at about 3 h. Concentrations of free naringenin hardly elevated above baseline. Plasma levels of free and conjugated naringenin chalcone significantly increased. A maximum of the conjugated chalcone was reached at about 3 h after ingestion with an average concentration of about 0.5 nmol/L. No free chalcone was detectable at baseline but low amounts of the unconjugated compound could be detected with an average maximum of 0.8 nmol/L at about 1 h after ingestion. The data demonstrate that naringenin chalcone is bioavailable in humans from cherry tomatoes as a dietary source. However, availability is poor and intramolecular cyclisation as well as extended metabolism likely contribute to the inactivation of the reactive alpha-beta unsaturated reactive center as well as the excretion of the biologically active molecule, respectively.

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