scholarly journals Pharmacoeconimic analysis of continuous subcutaneous insulin infusion compared with multiple daily injection in the treatment of patients with type 1 diabetes mellitus in the Russian Federation

2019 ◽  
Vol 7 (2) ◽  
pp. 17-21
Author(s):  
R.I Yagudina ◽  
E.O. Kostina
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Russian Federation ◽  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Daily Injection ◽  
Subcutaneous Insulin ◽  
Multiple Daily Injection ◽  
The Russian Federation

scholarly journals HbA1c variability in adults with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) therapy compared to multiple daily injection (MDI) treatment

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e033059 ◽  
Author(s):  
Emma S Scott ◽  
Rachel T McGrath ◽  
Andrzej S Januszewski ◽  
Daniel Calandro ◽  
Anandwardhan A Hardikar ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Daily Injection ◽  
Subcutaneous Insulin ◽  
Multiple Daily Injection ◽  
Retrospective Audit ◽  
Hba1c Variability

ObjectiveTo determine if continuous subcutaneous insulin infusion (CSII) therapy is associated with lower glycated haemoglobin (HbA1c) variability (long-term glycaemic variability; GV) relative to multiple daily injection (MDI) treatment in adults with type 1 diabetes mellitus (T1DM).DesignRetrospective audit.Setting and participantsClinic records from 506 adults with T1DM from two tertiary Australian hospitals.Outcome measuresLong-term GV was assessed by HbA1c SD and coefficient of variation (CV) in adults on established MDI or CSII therapy, and in a subset changing from MDI to CSII.ResultsAdults (n=506, (164 CSII), 50% women, mean±SD age 38.0±15.3 years, 17.0±13.7 years diabetes, mean HbA1c 7.8%±1.2% (62±13 mmol/mol) on CSII, 8.0%±1.5% (64±16 mmol/mol) on MDI) were followed for 4.1±3.6 years. CSII use was associated with lower GV (HbA1c SD: CSII vs MDI 0.5%±0.41% (6±6 mmol/mol) vs 0.7%±0.7% (9±8 mmol/mol)) and CV: CSII vs MDI 6.7%±4.6% (10±10 mmol/mol) vs 9.3%±7.3% (14±13 mmol/mol), both p<0.001. Fifty-six adults (73% female, age 36±13 years, 16±13 years diabetes, HbA1c 7.8%±0.8% (62±9 mmol/mol)) transitioned from MDI to CSII. Mean HbA1c fell by 0.4%. GV from 1 year post-CSII commencement decreased significantly, HbA1c SD pre-CSII versus post-CSII 0.7%±0.5% (8±5 mmol/mol) vs 0.4%±0.4% (5±4 mmol/mol); p<0.001, and HbA1c CV 9.2%±5.5% (13±8 mmol/mol) vs 6.1%±3.9% (9±5 mmol/mol); p<0.001.ConclusionsIn clinical practice with T1DM adults relative to MDI, CSII therapy is associated with lower HbA1c GV.

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