scholarly journals Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study

2018 ◽  
Vol 15 (9) ◽  
pp. 891-899 ◽  
Author(s):  
Ye-Ha Jung ◽  
Hyeonjin Kim ◽  
So Yeon Jeon ◽  
Jeong Min Kwon ◽  
Won Joon Lee ◽  
...  
Neuroreport ◽  
2019 ◽  
Vol 30 (2) ◽  
pp. 108-112 ◽  
Author(s):  
Ye-Ha Jung ◽  
Hyeonjin Kim ◽  
So Yeon Jeon ◽  
Jeong Min Kwon ◽  
Yong Chul Kim ◽  
...  

2020 ◽  
Author(s):  
Gillian Macnaught ◽  
Olga Oikonomidou ◽  
Christopher T. Rodgers ◽  
William Clarke ◽  
Annette Cooper ◽  
...  

Abstract PURPOSETo explore the utility of phosphorus magnetic resonance spectroscopy (31P MRS) in identifying anthracycline-induced cardiac toxicity in patients with breast cancer.METHODS20 patients with newly diagnosed breast cancer receiving anthracycline-based chemotherapy had cardiac magnetic resonance assessment of left ventricular ejection fraction (LVEF) and 31P MRS to determine myocardial Phosphocreatine/Adenosine Triphosphate ratio (PCr/ATP) at three time points: pre, mid and end-chemotherapy. Plasma high sensitivity cardiac troponin-I (cTn-I) tests and electrocardiograms were also performed at these same time points. RESULTS PCr/ATP ratio did not change significantly between pre- and mid-chemo (2.16±0.46 v 2.00±0.56, p=0.80) and pre- and end-chemo (2.16±0.46 v 2.17±0.86, p=0.99). Mean LVEF reduced significantly by 5.1% between pre- and end-chemo (61.4±4.4 vs 56.3±8.1 %, p=0.02). Change in PCr/ATP ratios from pre- to end-chemo correlated inversely with changes in LVEF over the same period (r=-0.65, p=0.006). Plasma cTn-I increased progressively during chemotherapy from pre- to mid-chemo (1.35±0.81 to 4.40±2.64 ng/L; p=0.01) and from mid to end-chemo (4.40±2.64 to 18.33±13.23 ng/L; p=0.001). CONCLUSIONSIn this small cohort pilot study, we did not observe a clear change in mean PCr/ATP values during chemotherapy despite evidence of increased plasma cardiac biomarkers and reduced LVEF. Future similar studies should be adequately powered to take account of patient drop-out and variable changes in PCr/ATP.


2019 ◽  
Vol 10 ◽  
Author(s):  
Erin J. Meyer ◽  
Jeffrey N. Stout ◽  
Ai Wern Chung ◽  
P. Ellen Grant ◽  
Rebekah Mannix ◽  
...  

2019 ◽  
Vol Volume 15 ◽  
pp. 839-847 ◽  
Author(s):  
Beata Galińska-Skok ◽  
Agata Szulc ◽  
Aleksandra Małus ◽  
Beata Konarzewska ◽  
Urszula Cwalina ◽  
...  

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