scholarly journals Vertical Transmission in a Two-Strain Model of Dengue Fever

2014 ◽  
Vol 1 (2) ◽  
Author(s):  
David Murillo ◽  
Susan Holechek ◽  
Anarina Murillo ◽  
Fabio Sanchez ◽  
Carlos Castillo-Chavez
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
Strain Model

scholarly journals Vertical Transmission in a Two-Strain Model of Dengue Fever

2014 ◽  
Vol 1 (2) ◽  
pp. 249-271 ◽  
Author(s):  
David Murillo ◽  
Susan A. Holechek ◽  
Anarina L. Murillo ◽  
Fabio Sanchez ◽  
Carlos Castillo-Chavez
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
Strain Model

scholarly journals The Role of Vertical Transmission in the Control of Dengue Fever

2019 ◽  
Vol 16 (5) ◽  
pp. 803 ◽  
Author(s):  
David Murillo ◽  
Anarina Murillo ◽  
Sunmi Lee
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
Disease Transmission ◽  
Control Function ◽  
Infected Mosquito ◽  
Effective Control ◽  
Control Policies ◽  
Effective Interventions ◽  
Endemic Strain

In this work, a two-strain dengue model with vertical transmission in the mosquito population is considered. Although vertical transmission is often ignored in models of dengue fever, we show that effective control of an outbreak of dengue can depend on whether or not the vertical transmission is a significant mode of disease transmission. We model the effect of a control strategy aimed at reducing human-mosquito transmissions in an optimal control framework. As the likelihood of vertical transmission increases, outbreaks become more difficult and expensive to control. However, even for low levels of vertical transmission, the additional, uncontrolled, transmission from infected mosquito to eggs may undercut the effectiveness of any control function. This is of particular importance in regions where existing control policies may be effective and the endemic strain does not exhibit vertical transmission. If a novel strain that does exhibit vertical transmission invades, then existing, formerly effective, control policies may no longer be sufficient. Therefore, public health officials should pay more attention to the role of vertical transmission for more effective interventions and policy.

Molecular identification of the first local dengue fever outbreak in Shenzhen city, China: a potential imported vertical transmission from Southeast Asia?

2013 ◽  
Vol 142 (2) ◽  
pp. 225-233 ◽  
Author(s):  
F. YANG ◽  
G. Z. GUO ◽  
J. Q. CHEN ◽  
H. W. MA ◽  
T. LIU ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Dengue Fever ◽  
Vertical Transmission ◽  
Serum Samples ◽  
Phylogenetic Tree Analysis ◽  
Molecular Fingerprints ◽  
Imported Case ◽  
Shenzhen City ◽  
Gene Homology ◽  
Close Relationship

SUMMARYA suspected dengue fever outbreak occurred in 2010 at a solitary construction site in Shenzhen city, China. To investigate this epidemic, we used serological, molecular biological, and bioinformatics techniques. Of nine serum samples from suspected patients, we detected seven positive for dengue virus (DENV) antibodies, eight for DENV-1 RNA, and three containing live viruses. The isolated virus, SZ1029 strain, was sequenced and confirmed as DENV-1, showing the highest E-gene homology to D1/Malaysia/36000/05 and SG(EHI)DED142808 strains recently reported in Southeast Asia. Further phylogenetic tree analysis confirmed their close relationship. At the epidemic site, we also detected 14 asymptomatic co-workers (out of 291) positive for DENV antibody, and DENV-1-positive mosquitoes. Thus, we concluded that DENV-1 caused the first local dengue fever outbreak in Shenzhen. Because no imported case was identified, the molecular fingerprints of the SZ1029 strain suggest this outbreak may be due to vertical transmission imported from Southeast Asia.

scholarly journals Vertical transmission of dengue fever: First case reported in Taiwan

2015 ◽  
Vol 114 (6) ◽  
pp. 558-559 ◽  
Author(s):  
Shu-Ting Yang ◽  
Hsiu-Lin Chen ◽  
Chun-Tai Yeh ◽  
Wei-Te Lee
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
First Case

SEROTYPE REPLACEMENT OF VERTICALLY TRANSMITTED DISEASES THROUGH PERFECT VACCINATION

2008 ◽  
Vol 16 (02) ◽  
pp. 255-277 ◽  
Author(s):  
DOUGLAS H. THOMASEY ◽  
MAIA MARTCHEVA
Keyword(s):  
Vertical Transmission ◽  
Reproduction Number ◽  
Vaccination Campaign ◽  
Theoretical Studies ◽  
Trade Off ◽  
Differential Effectiveness ◽  
Serotype Replacement ◽  
Super Infection ◽  
Strain Model

Strain replacement occurs when after a vaccination campaign one (or more) strains decline in prevalence while another strain (or strains) rise in prevalence. Differential effectiveness of the vaccine is the widely accepted and the most important mechanism which leads to this replacement effect. Recent theoretical studies have suggested that strain replacement may occur even if the vaccine is perfect, that is, the vaccine is completely effective with respect to all strains present. It has already been shown that perfect vaccination, along with a trade-off mechanism, such as co-infection or super-infection, lead to strain replacement. In this paper, we examine the hypothesis that strain replacement with perfect vaccination occurs only with trade-off mechanisms which allow a strain with a lower reproduction number to eliminate a strain with a higher reproduction number in the absence of vaccination. We test this hypothesis on a two-strain model with vertical transmission. We first show that vertical transmission as a trade-off mechanism can lead to dominance of a strain with suboptimal reproduction number. Based on the hypothesis we expect, and we show, that strain replacement occurs with vertical transmission.

scholarly journals Modeling the dengue fever transmission in a periodic environment

2021 ◽  
Vol 55 (1) ◽  
pp. 71-107
Author(s):  
Julián Alejandro Olarte ◽  
Anibal Muñoz
Keyword(s):  
Dengue Fever ◽  
Vertical Transmission ◽  
Ecological Factors ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infected People ◽  
Periodic Environment ◽  
Threshold Conditions ◽  
Definition Of ◽  
Disease Free

A mathematical model for dengue fever transmission is analyzed, which incorporates relevant biological and ecological factors: vertical transmission and seasonality in the interaction between the vector (Aedes aegypti females) and the host (human). The existence and uniqueness of a positive disease-free periodic solution is proved; the global stability of the disease-free solution and the effect of periodic migrations of mosquitoes carrying the virus on the transmission of dengue are analyzed utilizing the mathematical definition of the Basic Reproductive Number in periodic environments; finally, it is numerically corroborated with the help of the Basic Reproductive Number that dengue cannot invade the disease-free state if it is less than one and can invade if it is greater than one, however, in both threshold conditions when vertical transmission occurs, the number of infected people and carrier vectors rises, representing a mechanism for the persistence of dengue cases in a community throughout a natural year.

Dengue Fever Reemerges in Florida After 75 Years

2010 ◽  
Vol 44 (8) ◽  
pp. 19
Author(s):  
ROXANNA GUILFORD-BLAKE
Keyword(s):  
Dengue Fever
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