scholarly journals The Role of Explicit and Implicit Confidence in Multi Stage Decisions

2020 ◽  
Vol 22 (3) ◽  
pp. 37-47
Author(s):  
Fatemeh Majdabadi ◽  
Reza Ebrahimpour ◽  
◽  
Keyword(s):  
Multi Stage

Regulation of microRNAs in Inflammation-Associated Colorectal Cancer: A Mechanistic Approach

2020 ◽  
Vol 20 ◽  
Author(s):  
Sridhar Muthusami ◽  
Ilangovan Ramachandran ◽  
Sneha Krishnamoorthy ◽  
Yuvaraj Sambandam ◽  
Satish Ramalingam ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Mechanisms ◽  
Colorectal Carcinogenesis ◽  
Model Systems ◽  
Necrosis Factor Alpha ◽  
Multi Stage ◽  
Mechanistic Approach ◽  
Tnf Α ◽  
Factor Alpha

: The development of colorectal cancer (CRC) is a multi-stage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn’s disease (CD) is often regarded as the initial trigger for the development of CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and several interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC through differential regulation of microRNAs (miRNAs/miRs). miRNAs can be oncogenic miRNAs (oncomiRs) or anti-oncomiRs/tumor suppressor miRNAs, and they play key roles during colorectal carcinogenesis. However, the functions and molecular mechanisms of regulation of miRNAs involved in inflammation-associated CRC are still anecdotal and largely unknown. Consolidating the published results and offering perspective solutions to circumvent CRC, the current review is focused on the role of miRNAs and their regulation in the development of CRC. We have also discussed the model systems adapted by researchers to delineate the role of miRNAs in inflammation-associated CRC.

scholarly journals Entrepreneurial decisions: Insights into the use of support services for new business creation

2014 ◽  
Vol 45 (4) ◽  
pp. 11-20 ◽  
Author(s):  
G. Ammetller ◽  
I. Rodriguez-Ardurab ◽  
J. Llados-Masllorens
Keyword(s):  
Decision Making ◽  
Support Services ◽  
Local Development ◽  
Integrative Model ◽  
Resource Based View ◽  
Utilization Of Services ◽  
Multi Stage ◽  
Business Creation ◽  
New Business

This research presents an integrative model about the use of those services that have been specifically designed to support entrepreneurial initiative. By contrast with conventional perspectives from the entrepreneurship field, mainly drawn from a resource-based view, we propose a two-fold approach to explain the utilization of services that are oriented to new business creation: by considering the role of resources within the start-up's reach (internal and external); by incorporating a behavioral and decision-making approach. On the basis of the suggested decision-making framework, a multi-stage decision model is developed and tested by means of a representative sample of entrepreneurs linked to a local development agency. The results show that the adoption and use of support services for new business creation is a complex and reflexive process, triggered by the entrepreneur's internal forces.The entrepreneur searches for information throughout the process and, with assistance from internal teams and external networks, evaluates the choices of businesssupport services. Our findings offer relevant implications and recommendations for business incubators and institutions.

scholarly journals Impact Size and Determinants of Indirect Cost of Financial Distress: Role of Receivable and Inventory Management

2020 ◽  
Vol 16 (2) ◽  
pp. 179-207
Author(s):  
Umar Farooq ◽  
Muhammad Ali Jibran Qamar ◽  
Krishna Reddy
Keyword(s):  
Indirect Cost ◽  
Inventory Management ◽  
Financial Distress ◽  
Multi Stage ◽  
Initial Stage ◽  
Non Linear ◽  
Management Policies ◽  
Internal Operations ◽  
The Impact

This research investigates the opportunity cost as an indirect cost of financial distress from two perspectives. First, indirect cost is estimated using multi-stage financial distress and non-linear proxy of debt. Second, receivable and inventory management are studied as determinants of indirect cost. The sample includes ongoing Pakistani firms that were healthy in the previous year and documenting positive gross profit. Results showed that firms bear opportunity loss primarily due to leverage rather than multistage financial distress. However, a non-linear relationship is found between leverage and indirect cost. Results further explored the impact of multistage financial distress on internal operations, i.e., working capital policies. It is found that firms manage receivable and inventory simultaneously during the multistage financial distress. Results revealed that increasing receivables and decreasing inventory is suitable during the transition of healthy firms to initial stage of financial distress, i.e., profit reduction. However, decreasing receivables, along with holding more inventory, is recommended for healthy firms that face liquidity problems subsequently. It is concluded that managers can reduce the indirect cost after deploying the optimal debt ratio and recommended receivable and inventory management policies.

scholarly journals Mechanisms of Metastasis and Cell Mobility – The Role of Metabolism

2019 ◽  
Vol 79 (02) ◽  
pp. 184-188 ◽  
Author(s):  
Carsten Gründker ◽  
Matthias Läsche ◽  
Johanna Hellinger ◽  
Günter Emons
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Early Stage ◽  
Breast Cancer Patients ◽  
Metastatic Cascade ◽  
Cell Mobility ◽  
Tumour Metastasis ◽  
Multi Stage ◽  
Mesenchymal Transformation

AbstractTumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the “metastatic cascade” or “metastatic cycle” is a complex and multi-stage event. While it is generally recognised that epithelial-mesenchymal transformation (EMT) plays a crucial role in cancer progression and metastasis, the metabolic events in this process have received little attention to date. We would therefore like to provide a brief overview here of the influence of the metabolism on the progression and metastasis of tumours.

How Does Servant Leadership Behaviour Affect Job Satisfaction? A Study on Indian Academia

2020 ◽  
pp. 231971452096869
Author(s):  
Sonika Singh ◽  
Piar Chand Ryhal
Keyword(s):  
Job Satisfaction ◽  
Servant Leadership ◽  
Structural Equation ◽  
Sampling Technique ◽  
Himachal Pradesh ◽  
North India ◽  
Teaching Staff ◽  
High Performing ◽  
Multi Stage

The importance of and focus on educational leadership have been increasing, but there have been insufficient studies in India testing the role of servant leadership (SL) and its impact on the job satisfaction (JS) of teaching staff. The present study examines the role of the SL behaviour of school principals and its impact on JS. Data were collected from 728 secondary school teachers belonging to Himachal Pradesh, a state of North India, using the multi-stage probability sampling technique. Mean, correlation and structural equation modelling (SEM) were employed in the data analysis to test our hypotheses. Statistical analysis revealed that teachers perceive a moderate level of JS and SL. A significant positive correlation was found between SL and JS, and SL was found to have a positive and significant impact on JS. The squared multiple correlation value ( R2) showed a 57 per cent variance in JS among academic teaching staff. Despite being one of the educationally and economically high-performing states, Himachal Pradesh has not been the focus of educational researchers. The present study contributes to build and add knowledge on SL and JS by exploring the relationship between the two.

Manganoan fayalite and products of its alteration from the Strzegom pegmatites, Poland

1989 ◽  
Vol 53 (371) ◽  
pp. 315-325 ◽  
Author(s):  
J. Janeczek
Keyword(s):  
Hydrothermal Alteration ◽  
Fluid Inclusions ◽  
Iron Hydroxide ◽  
Silicate Phase ◽  
Second Stage ◽  
Multi Stage ◽  
Composite Mixture ◽  
Quartz Aggregates ◽  
Lower Silesia

AbstractNodules of manganoan fayalite occur in schlieren pegmatities in the vicinity of Strzegom, Lower Silesia. The fayalite, Na0.02(Fe1.812+Mn0.16Mg 0.03)Si0.99O4, is unzoned and non pleochroic. 2Va = 42° a 4.826(3), b 10.500(2), c 6.102(2) A, d130obs. = 2.83 Å, d130calc. = 2.833 Å, D = 4.35 g cm-3, Dcalc. = 4.353 g cm-3. The role of Na+ ions in the fayalite chemistry is discussed. The fayalite underwent multi-stage hydrothermal alteration beginning at the highest temperature (440°C) of homogenization of gaseous-fluid inclusions in quartz adjacent to the fayalite grains. Increase in fO2 and then in PH2O resulted in the formation of magnetite-quartz and Mn-grunerite-magnetite-quartz aggregates within the fayalite grains. The fayalite is mantled by a Mn-greenalite-magnetite rim, Mn-grunerite-magnetite-Mn-minnesotaite zone in a stilpnomelane or greenalite-rich groundmass. The minnesotaite is believed to have formed at the expense of grunerite. Stilpnomelane, the most abundant silicate phase in the rim, is the product of biotite and presumably greenalite alteration at the second stage of increasing Na activity (the crystallization of cleavelandite) in the pegmatites. The fayalite is also heavily altered to iddingsite—a composite mixture of amorphous FeOOH and silica. The iron-hydroxide recrystallized partially to poorly-crystalline goethite.

scholarly journals Life negative events and depressive symptoms: the China Longitudinal Ageing Social Survey

2020 ◽  
Author(s):  
Zhenjie Wang ◽  
Hanmo Yang ◽  
Pianpian Zheng ◽  
Bei Liu ◽  
Zhanyuan Guo ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Rural Areas ◽  
Depressive Disorders ◽  
Negative Events ◽  
Social Survey ◽  
Chinese Older Adults ◽  
Probabilistic Sampling ◽  
Multi Stage

Abstract Background: Although some studies have reported the association between life negative events and depressive disorders, very limited studies have examined the association between life negative events exposure and depressive symptoms risk among Chinese older adults. Methods : Data were obtained from the China Longitudinal Ageing Social Survey (CLASS), which was a stratified, multi-stage, probabilistic sampling survey, conducted in 2014. General linear regression and logistic regression were used to examine the association between life negative events exposure and depressive symptoms among Chinese older adults. Results: Life negative events showed statistical dose-response association with depressive symptoms risk after adjustment for the confounding factors ( P trend <0.001). Under consideration of life negative events exposure, participants who lived in rural areas, without a spouse or live alone were vulnerable to depressive symptoms. Conclusions: Life negative events played a risk role of depressive symptoms among Chinese older adults, especially among those in rural areas, females or without a spouse. Our current study is valuable for the development of special prevention depressive symptoms programs among elderly individuals, especially those who have experienced negative events.

scholarly journals Life negative events and depressive symptoms: the China Longitudinal Ageing Social Survey

2020 ◽  
Author(s):  
Zhenjie Wang ◽  
Hanmo Yang ◽  
Pianpian Zheng ◽  
Bei Liu ◽  
Zhanyuan Guo ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Rural Areas ◽  
Depressive Disorders ◽  
Negative Events ◽  
Social Survey ◽  
Chinese Older Adults ◽  
Probabilistic Sampling ◽  
Multi Stage

Abstract Background: Although some studies have reported the association between life negative events and depressive disorders, very limited studies have examined the association between life negative events exposure and depressive symptoms risk among Chinese older adults.Methods: Data were obtained from the China Longitudinal Ageing Social Survey (CLASS), which was a stratified, multi-stage, probabilistic sampling survey, conducted in 2014. General linear regression and logistic regression were used to examine the association between life negative events exposure and depressive symptoms among Chinese older adults.Results: Life negative events showed statistical dose-response association with depressive symptoms risk after adjustment for the confounding factors (P trend <0.001). Under consideration of life negative events exposure, participants who lived in rural areas, without a spouse or live alone were vulnerable to depressive symptoms.Conclusions: Life negative events played a risk role of depressive symptoms among Chinese older adults, especially among those in rural areas, females or without a spouse. Our current study is valuable for the development of special prevention depressive symptoms programs among elderly individuals, especially those who have experienced negative events.

Understanding How Information Technology Can Help in Contracts Management

2021 ◽  
pp. 99-120
Keyword(s):  
Information Technology ◽  
Cost Optimization ◽  
Design Management ◽  
Smart Contracts ◽  
Materials Management ◽  
Blockchain Technology ◽  
Multi Stage ◽  
Stage Process

Contracts management is a multi-stage process involving all parties related to a contract. It ensures that all stated objectives are met, and timelines adhered to corresponding to project execution and delivery. The fundamental premise of contracts management is to ensure quality, compliance, and cost optimization. There are several forms of contract each with its own unique features and applications. In this chapter, the authors focus on how information technology can be used to aid in supervision of contracts, materials management, survey, and design management. They also discuss the role of smart contracts and the underlying blockchain technology that is used as the basis for making smart contracts work.

Sign in / Sign up

Export Citation Format

Share Document