scholarly journals The Role of Temozolomide-Irinotecan in Doxorubicin- Resistant Cell Lines of Recurrent Ewing’s Sarcoma, in A Patient Derived Orthotopic Xenograft (PDOX) with EWS-ERG Fusion and CDKN2A Loss: What Impact the Combination has in Real Life Practice?

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Maher Salamoon ◽  
Mehdi Balti ◽  
Bertrand Farnault ◽  
Maher Saifo ◽  
Ali Mahmoud ◽  
...  
Keyword(s):  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Real Life ◽  
Resistant Cell ◽  
Orthotopic Xenograft

scholarly journals Characterization and Drug Resistance Patterns of Ewing's Sarcoma Family Tumor Cell Lines

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80060 ◽  
Author(s):  
William A. May ◽  
Rita S. Grigoryan ◽  
Nino Keshelava ◽  
Daniel J. Cabral ◽  
Laura L. Christensen ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Tumor Cell ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Tumor Cell Lines ◽  
Resistance Patterns

Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy

2004 ◽  
Author(s):  
Gaetano Bacci ◽  
Stefano Ferrari ◽  
Alessandra Longhi ◽  
Davide Donati ◽  
Enza Barbieri ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Local Treatment

Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with aFUS-ERGfusion andCDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model

2017 ◽  
Vol 119 (1) ◽  
pp. 967-972 ◽  
Author(s):  
Kentaro Miyake ◽  
Takashi Murakami ◽  
Tasuku Kiyuna ◽  
Kentaro Igarashi ◽  
Kei Kawaguchi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Nude Mouse ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Nude Mouse Model ◽  
Orthotopic Xenograft

Ewing's sarcoma in childhood — The role of radiotherapy

1997 ◽  
Vol 33 ◽  
pp. S109
Author(s):  
Maria Adelina Costa ◽  
Lurdes Alves ◽  
Isabel Silva ◽  
Ma VirgInia Costa ◽  
Armando Pinto ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma

Abstract 3158: Evidence for a role of EWS in alternative splicing in Ewing's sarcoma

2010 ◽  
Author(s):  
Lucia T. Riedmann ◽  
Maximilian O. Kauer ◽  
Gunhild Jug ◽  
Heinrich Kovar
Keyword(s):  
Alternative Splicing ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma

scholarly journals An Innovative Therapeutic Option for the Treatment of Skeletal Sarcomas: Elimination of Osteo- and Ewing’s Sarcoma Cells Using Physical Gas Plasma

2020 ◽  
Vol 21 (12) ◽  
pp. 4460 ◽  
Author(s):  
Josephine M. Jacoby ◽  
Silas Strakeljahn ◽  
Andreas Nitsch ◽  
Sander Bekeschus ◽  
Peter Hinz ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Therapeutic Option ◽  
Bone Sarcoma ◽  
Atmospheric Plasma ◽  
Local Surgery ◽  
Release Assay ◽  
Sarcoma Cells

Osteosarcoma and Ewing’s sarcoma are the most common malignant bone tumors. Conventional therapies such as polychemotherapy, local surgery, and radiotherapy improve the clinical outcome for patients. However, they are accompanied by acute and chronic side effects that affect the quality of life of patients, motivating novel research lines on therapeutic options for the treatment of sarcomas. Previous experimental work with physical plasma operated at body temperature (cold atmospheric plasma, CAP) demonstrated anti-oncogenic effects on different cancer cell types. This study investigated the anti-cancer effect of CAP on two bone sarcoma entities, osteosarcoma and Ewing’s sarcoma, which were represented by four cell lines (U2-OS, MNNG/HOS, A673, and RD-ES). A time-dependent anti-proliferative effect of CAP on all cell lines was observed. CAP-induced alterations in cell membrane functionality were detected by performing a fluorescein diacetate (FDA) release assay and an ATP release assay. Additionally, modifications of the cell membrane and modifications in the actin cytoskeleton composition were examined using fluorescence microscopy monitoring dextran-uptake assay and G-/F-actin distribution. Furthermore, the CAP-induced induction of apoptosis was determined by TUNEL and active caspases assays. The observations suggest that a single CAP treatment of bone sarcoma cells may have significant anti-oncogenic effects and thus may be a promising extension to existing applications.

Role of surgical resection in pelvic Ewing's sarcoma.

1995 ◽  
Vol 13 (9) ◽  
pp. 2336-2341 ◽  
Author(s):  
S P Scully ◽  
H T Temple ◽  
R J O'Keefe ◽  
M T Scarborough ◽  
H J Mankin ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Disease Control ◽  
Surgical Resection ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Disease Free Survival ◽  
Local Disease ◽  
Local Disease Control

PURPOSE The improved survival in patients with Ewing's sarcoma over the past two decades has placed increased importance on achievement of local disease control. Ewing's sarcoma that arises in the pelvis has been recognized to have a worse prognosis than that in the appendicular skeleton, and the role of surgical resection in these cases remains controversial. The current study attempts to identify a benefit to surgical resection in these patients. METHODS We retrospectively examined 39 patients who presented with Ewing's sarcoma in a pelvic location, all of whom were treated systemically with chemotherapy. Twenty patients received radiation only as a means of local control, and 19 underwent resection with or without radiation therapy. The patients were evaluated with end points of disease-free survival and overall survival for a minimum of 24 months and a mean of 58 months. RESULTS There was an even distribution among patients who underwent surgical resection for local control as compared with those who received only radiation therapy with respect to age, site, date of treatment, and stage of disease. Despite uncontrolled biases including tumor size and response to chemotherapy that would be expected to favor patients who undergo resection, surgery in addition to or in substitution for radiation therapy did not result in a statistically significant increase in disease-free survival or overall survival. Local disease control was comparable between those who underwent resection and those who did not: three patients in each group developed a local recurrence. CONCLUSION Currently, morbidity of surgical resection should be weighed against the efficacy and secondary complications of radiation therapy in the decision-making process for local disease control. The issue of whether overall survival and local disease control is improved in patients who undergo surgical resection remains controversial and may require a prospective randomized trial to be answered definitively.

scholarly journals Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing’s sarcoma cell lines

2007 ◽  
Vol 103 (4) ◽  
pp. 1344-1354 ◽  
Author(s):  
Cristina Zanini ◽  
Giuliana Giribaldi ◽  
Giorgia Mandili ◽  
Franco Carta ◽  
Nicoletta Crescenzio ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Cell Lines ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Sarcoma Cell ◽  
Shock Proteins
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