scholarly journals Immunohistochemical studies of the Upregulation of BCL-2 and Downregulation of Bax in the Hippocampus of STZ-induced Type 1 Diabetic Rats Co-administered Melatonin and Magnesium

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Elvis T. Godam ◽  
Wilson O. Hamman ◽  
Sunday Oladele ◽  
Modupeola O. Samaila ◽  
Sunday A. Musa
Keyword(s):  
Diabetic Rats ◽  
Immunohistochemical Studies

scholarly journals Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats

Cell Reports ◽  
2020 ◽  
Vol 32 (13) ◽  
pp. 108207
Author(s):  
Xiao Wei ◽  
Zongshi Lu ◽  
Li Li ◽  
Hexuan Zhang ◽  
Fang Sun ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Ampk Activity

Piroxicam reduces acute and chronic pain response in type 1 diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Abbas Alimoradian ◽  
Fatemeh Samimi ◽  
Hadise Aslfalah ◽  
Seied Amirhossein Latifi ◽  
Mehdi Salehi ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Normal Saline ◽  
Life Quality ◽  
Chronic Phase ◽  
Diabetic Rats ◽  
Effective Control ◽  
Diabetic Patients ◽  
Formalin Injection ◽  
Analgesic Effects

Abstract Objectives Pain associated with various underlying pathologies is a major cause of morbidity and diminished life quality in diabetic patients. Effective control of pain requires the use of analgesics with the best efficacy and with minimal side effects. Therefore, our aim in this study was to investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on pain in diabetic rats. Methods In this study, we investigated the analgesic effects of drugs belonging to three different classes of NSAIDs in a rat model of diabetes. Four diabetic groups received normal saline, diclofenac, piroxicam and ketorolac, respectively, and four non-diabetic groups received normal saline, diclofenac, piroxicam and ketorolac. Type 1 diabetes was induced in rats by a single injection of streptozotocin (60 mg/kg bw). Formalin (50 µL of 2.5%) nociception assay was used to examine the effect of treatment with diclofenac, piroxicam and ketorolac on acute and chronic pain in healthy and diabetic rats. Results Piroxicam showed significant analgesic effects both in the acute phase of pain (5–10 min after injection of formalin into the left hind paw), and in the chronic phase (20–60 min after formalin injection) in healthy as well as diabetic rats. Diclofenac and ketorolac also reduced pain scores in healthy rats. However, these two drugs failed to diminish pain in diabetic rats. Conclusion Our data point for better efficacy of piroxicam in controlling pain in diabetes.

scholarly journals Abnormalities in the brain of streptozotocin-induced type 1 diabetic rats revealed by diffusion tensor imaging

2012 ◽  
Vol 1 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Mingming Huang ◽  
Lifeng Gao ◽  
Liqin Yang ◽  
Fuchun Lin ◽  
Hao Lei
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Diabetic Rats ◽  
The Brain

scholarly journals Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced Type 1 diabetic rats

2014 ◽  
Vol 4 ◽  
pp. S421-S425 ◽  
Author(s):  
Hassan Ahmadvand ◽  
Akram Noori ◽  
Maryam Ghasemi Dehnoo ◽  
Shahrokh Bagheri ◽  
Rooh Angiz Cheraghi
Keyword(s):  
Diabetic Rats

scholarly journals Beneficial Effect of Aqueous Garlic Extract on Inflammation and Oxidative Stress Status in the Kidneys of Type 1 Diabetic Rats

2016 ◽  
Vol 32 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Abolfazl Nasiri ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Mohammad Taghi Goodarzi ◽  
Massoud Saidijam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Diabetic Rats ◽  
Garlic Extract ◽  
Oxidative Stress Status ◽  
And Oxidative Stress
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