scholarly journals The Role of Macrophage Migration Inhibitory Factor (MIF) in Acute Kidney Injury

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Jinhong Li ◽  
Wenqian Xu ◽  
Na Li ◽  
Yiqing Zhang ◽  
Xiaohua Wang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Kidney Injury ◽  
Inhibitory Factor ◽  
Macrophage Migration

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery

2018 ◽  
Vol 10 (441) ◽  
pp. eaan4886 ◽  
Author(s):  
Christian Stoppe ◽  
Luisa Averdunk ◽  
Andreas Goetzenich ◽  
Josefin Soppert ◽  
Arnaud Marlier ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Kidney Injury ◽  
Protective Role ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery

2020 ◽  
Vol 9 (9) ◽  
pp. 2936
Author(s):  
Luisa Averdunk ◽  
Jürgen Bernhagen ◽  
Karl Fehnle ◽  
Harald Surowy ◽  
Hermann-Josef Lüdecke ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Elevated Serum ◽  
Kidney Injury ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Promoter Polymorphisms ◽  
Risk Of Death

Background: Macrophage Migration Inhibitory Factor (MIF) is highly elevated after cardiac surgery and impacts the postoperative inflammation. The aim of this study was to analyze whether the polymorphisms CATT5–7 (rs5844572/rs3063368,“-794”) and G>C single-nucleotide polymorphism (rs755622,-173) in the MIF gene promoter are related to postoperative outcome. Methods: In 1116 patients undergoing cardiac surgery, the MIF gene polymorphisms were analyzed and serum MIF was measured by ELISA in 100 patients. Results: Patients with at least one extended repeat allele (CATT7) had a significantly higher risk of acute kidney injury (AKI) compared to others (23% vs. 13%; OR 2.01 (1.40–2.88), p = 0.0001). Carriers of CATT7 were also at higher risk of death (1.8% vs. 0.4%; OR 5.12 (0.99–33.14), p = 0.026). The GC genotype was associated with AKI (20% vs. GG/CC:13%, OR 1.71 (1.20–2.43), p = 0.003). Multivariate analyses identified CATT7 predictive for AKI (OR 2.13 (1.46–3.09), p < 0.001) and death (OR 5.58 (1.29–24.04), p = 0.021). CATT7 was associated with higher serum MIF before surgery (79.2 vs. 50.4 ng/mL, p = 0.008). Conclusion: The CATT7 allele associates with a higher risk of AKI and death after cardiac surgery, which might be related to chronically elevated serum MIF. Polymorphisms in the MIF gene may constitute a predisposition for postoperative complications and the assessment may improve risk stratification and therapeutic guidance.

scholarly journals Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice

2018 ◽  
Vol 26 (10) ◽  
pp. 2523-2532 ◽  
Author(s):  
Jinhong Li ◽  
Ying Tang ◽  
Patrick M.K. Tang ◽  
Jun Lv ◽  
Xiao-ru Huang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Kidney Injury ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Urinary Macrophage Migration Inhibitory Factor Serves as a Potential Biomarker for Acute Kidney Injury in Patients with Acute Pyelonephritis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ming-Yuan Hong ◽  
Chin-Chung Tseng ◽  
Chia-Chang Chuang ◽  
Chia-Ling Chen ◽  
Sheng-Hsiang Lin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Migration Inhibitory Factor ◽  
Acute Pyelonephritis ◽  
Macrophage Migration Inhibitory Factor ◽  
Kidney Injury ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Nitrogen Levels ◽  
Potential Biomarker ◽  
Predictive Role

Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN). In addition to the MIF level, the urinary levels of interleukin (IL)-1βand kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF. An elevated urinary MIF level, along with elevated IL-1βand KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients.

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