scholarly journals Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

2020 ◽  
Author(s):  
Ahu Pakdemirli ◽  
Gizem Çalıbaşı Kocal ◽  
Gülser Kılınç ◽  
Ezgi Daşkın ◽  
Hande Kemaloğlu ◽  
...  
Keyword(s):  
Dental Caries ◽  
Inflammatory Cytokines ◽  
Cross Sectional Study ◽  
Bacterial Challenge ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pro Inflammatory Cytokines

scholarly journals Correlation between Circulating Levels of Pro-Inflammatory Cytokines TNF-alpha and Vascular Calcification Inhibitor Matrix Gla Protein in Obese Men

2010 ◽  
Vol 2 (3) ◽  
pp. 126
Author(s):  
Trilis Yulianti ◽  
Mansyur Arif ◽  
Andi Wijaya
Keyword(s):  
Vascular Calcification ◽  
Inflammatory Cytokines ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Matrix Gla Protein ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tnf Α ◽  
Circulating Levels ◽  
Pro Inflammatory Cytokines

BACKGROUND: Adult obesity is rapidly increasing in the world including Indonesia. Tumor necrosis factor α (TNF-α) was chronically elevated in obese adipose tissue. TNF-α, a pleiotropic cytokine and also a regulator of bone formation, may might represent an important link between obesity and vascular calcification. Elegant genetic studies in mice and human have highlighted the important roles for Matrix Gla Protein (MGP) as an inhibitor of vascular calcification. The aim of this study was to examine the correlation between circulating levels of pro-inflammatory cytokines TNF-α and vascular calcification inhibitor MGP in obese men.METHODS: This was an observational cross-sectional study including 40 central obese men (waist circumference ≥90 cm) aged 31-60 years old. Serum MGP and serum TNF-α concentrations were quantified by ELISA principle. Fasting plasma glucose was assessed using hexokinase methods, triglyceride by GPO-PAP methods, and creatinine by Jaffe methods. All assays were performed according to the manufacture instruction. Statistical analysis was performed with SPSS for windows ver 16. Univariate analysis were performed to analyze mean, maximum, minimum value and SD. Pearson correlation statistic were performed to determine the correlation between variables. Significance value were define as alpha level = 0.05 based on two-tailed tests.RESULTS: The cross-sectional study (n=40) showed that the advancing age was correlated with plasma TNF-α concentration (r=0.348; p=0.028). The mean concentration of TNF-α and MGP were 8.323 and 8.368, respectively. We found a significant negative correlation between TNF-α with MGP (r=-0.425; p=0.006) and a significant correlation between TNF-α and triglyceride (r=0.375; p=0.017).CONCLUSIONS: Circulating level of TNF-α was inversely correlated with MGP concentration in obese men. This finding suggested that high level TNF-α leads to low MGP concentration obese men, hence, limits inhibitory capacity in vascular calcification.KEYWORDS: hypertension, obesity, vascular calcification, MGP, TNF-α

scholarly journals Baricitinib in Rheumatoid Arthritis – Real World Cross-Sectional Study

2020 ◽  
Vol 14 (1) ◽  
pp. 28-33
Author(s):  
Amol Sagdeo ◽  
Ayman Askari ◽  
Hana Morrissey ◽  
Patrick A. Ball
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Cytokines ◽  
Local Population ◽  
Joint Stiffness ◽  
Cross Sectional Study ◽  
Electronic Patient Records ◽  
Sectional Study ◽  
Cross Sectional ◽  
Biologic Dmard ◽  
Pro Inflammatory Cytokines

Introduction: Rheumatoid Arthritis (RA) is the most common cause of inflammatory polyarthritis. In RA, increased circulating levels of pro-inflammatory cytokines contribute to the overall symptomatology of fatigue, pain, and joint stiffness. Baricitinib is an orally administered biologic DMARD, used in RA patients, inhibiting signaling via JAK1/JAK2 inhibition, reducing the release of pro-inflammatory cytokines. Objective: To explore the efficacy and tolerability for baricitinib in a local population. Methods: A cross-sectional study was carried out to review data of RA patients on Baricitinib from the researchers’ own clinic, since its approval in August 2017. The data was collected from an anonymized electronic patient records report. The clinical response was then classified into mild, moderate, and significant improvement. Results and Discussion: Overall, 27 out of 37 patients (72.9%) showed clinical improvement with baricitinib. In 9(24.3%) out of 37 patients, the dose had to be reduced to either 2mg/day or 2mg/day - 4mg/day on alternate days. In four of the 9 patients’ where the dose was reduced due to infections (UTI or sinuses), they subsequently experienced fewer infections while maintaining moderate improvement in their RA. Conclusion: There is a need for longer-term and larger studies to evaluate the full side effects profile of baricitinib in the local population.

scholarly journals Free Sugars Intake among Chinese Adolescents and Its Association with Dental Caries: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 765
Author(s):  
Qiping Yang ◽  
Yue Xi ◽  
Hanmei Liu ◽  
Jing Luo ◽  
Yufeng Ouyang ◽  
...  
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Cross Sectional Study ◽  
Chinese Adolescents ◽  
Food Sources ◽  
Caries Experience ◽  
Sectional Study ◽  
Cross Sectional ◽  
Free Sugars ◽  
Targeted Interventions

This study aims to estimate the free sugars intake, identify the primary food sources of free sugars, and explore the relationship between free sugars intake and dental caries among Chinese adolescents. This cross-sectional study included 1517 middle-school students aged 12–14 years in Changsha city, China. Adolescents completed a 12-item Food Frequency Questionnaire (FFQ) and oral health assessment. The students’ dental caries experience was available as DMFT score (number of decayed, missing, and filled permanent teeth). Statistical analyses included the Mann–Whitney test, Kruskal–Wallis test, Chi-square test, and binary logistic regression model. The average intake of free sugars was 53.1 g/d in adolescents, and 43.2% of the students consumed more than 50 g of free sugars daily. The primary contributor to free sugars was sugar-sweetened beverages (SSBs). Age, boarders, and high family income were risk factors for excessive free sugars intake (p < 0.05), and increased free sugars intake was a risk factor for dental caries (odds ratio, OR = 1.446, 95% confidence interval: 1.138–1.839). Both the free sugars intake and dental caries prevalence in Chinese adolescents were high. Targeted interventions are urgently needed to address the excessive consumption of free sugars and improve Chinese adolescents’ oral health.

scholarly journals Oral Health Status of 12-Year-Old Hani Children in the Yunnan Province of China: A Cross-Sectional Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5294
Author(s):  
Kitty Jieyi Chen ◽  
Ni Zhou ◽  
Biao Xu ◽  
Yuexiao Li ◽  
Shinan Zhang ◽  
...  
Keyword(s):  
Health Status ◽  
Oral Health ◽  
Dental Caries ◽  
Yunnan Province ◽  
Dental Fluorosis ◽  
Cross Sectional Study ◽  
Oral Health Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gingival Bleeding

Background: The aim of this cross-sectional study was to investigate the oral health status of Hani 12-year-old children in Yunnan, a province in Southwest China. Method: This study employed a multistage sampling method to recruit children from local primary schools. Two calibrated dentists examined the status of dental caries, gingival bleeding and dental fluorosis by adopting the diagnosis criteria recommended by the World Health Organization. A self-administrated questionnaire was distributed. The chi-square test and multivariate logistic regression were conducted. Results: This study invited 480 Hani children, and recruited 413 children (52% boys) (response rate: 86%). The dental caries prevalence was 52%, and the caries experience associated with the mean (standard deviation) decayed, missing and filled teeth (DMFT) score was 1.10 (1.46). Gingival bleeding was diagnosed in 252 children (61%), and dental fluorosis was found in two children (0.5%). The results of the regression model indicated the prevalence of dental caries were associated with sugary snacking habits (p = 0.002). The prevalence of gingival bleeding was related to the mother’s education level as well as the child’s monthly pocket money (p < 0.05). Conclusion: Dental caries and gingival bleeding were prevalent among 12-year-old Hani children in the Yunnan province in China. Dental fluorosis was uncommon.

scholarly journals Association between socioeconomic status and dental caries among Chinese preschool children: a cross-sectional national study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e042908
Author(s):  
Tingting Zhang ◽  
Jialan Hong ◽  
Xueting Yu ◽  
Qiulin Liu ◽  
Andi Li ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Preschool Children ◽  
Oral Health ◽  
Dental Caries ◽  
Household Income ◽  
Parental Education ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Index Of Inequality

ObjectivesSocioeconomic inequalities in oral health are often neglected in oral health promotion. This cross-sectional study assessed the association between dental caries and socioeconomic status (SES) among preschool children in China.DesignCross-sectional study.SettingData from the Fourth National Oral Health Survey of China (2015), comprising of 40 360 children aged 3–5 years was used.MethodsDental caries indicators including prevalence of dental caries, dental pain experience and number of decayed, missing and filling teeth (dmft). SES indicators included parental education and household income. The associations between SES and dental caries were analysed by using negative binomial regression or Poisson regression models according to data distribution. Relative and absolute inequalities in dental caries were quantified by using the Relative Index of Inequality (RII) and Slope Index of Inequality (SII), respectively.ResultsThere were significant associations between SES and prevalence of dental caries and dmft (p<0.001). Children from lower educated (RII 1.36, 95% CI 1.3 to 1.43; SII 0.97, 95% CI 0.81 to 1.13) and lower household income (RII 1.17, 95% CI 1.11 to 1.24; SII 0.55, 95% CI 0.35 to 0.75) families had higher dmft than those from well-educated and most affluent families. Relative and absolute inequalities in dental caries were larger in urban areas by household income, and in rural areas by parental education.ConclusionsAssociation between dental caries and SES was demonstrated and socioeconomic inequalities in dental caries existed among Chinese preschool children.

scholarly journals Pre-schoolers’ tooth brushing behaviour and association with their oral health: a cross sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Iqra Muhammad Khan ◽  
Shani Ann Mani ◽  
Jennifer Geraldine Doss ◽  
Mahmoud Danaee ◽  
Lydia Yi Li Kong
Keyword(s):  
Preschool Children ◽  
Oral Health ◽  
Dental Caries ◽  
Parental Involvement ◽  
Cross Sectional Study ◽  
Parental Supervision ◽  
Gingival Index ◽  
Sectional Study ◽  
Cross Sectional ◽  
Plaque Score

Abstract Background Toothbrushing is an important yet neglected behaviour that affects the oral health of preschool children. Little is reported on parental supervision, an essential aspect of routine effective toothbrushing in this age group. The aim of this study was to evaluate pre-schoolers’ toothbrushing behaviour including parental involvement and its association with their oral health. Methods This was a cross-sectional study. A total of 92 preschool children (4–6 years) were invited to participate with their parents/guardians. Nine parameters of toothbrushing behaviour were assessed from parental responses (questionnaire) and observation of child and parents/guardians (video recording). Oral examination included recording plaque, gingival and dental caries indices. BORIS software was used to assess toothbrushing parameters and Smart PLS was used to perform association with a second-generation multivariate analysis to create models with and without confounding factors. Results Girls were slightly more (53%) than boys (47%). Children aged 4 years were slightly more in number (38%), followed by 6-year-olds and 5-year-olds. Nearly, 90% parents had tertiary education and 46% had more than 2 children. Differences were recorded in the reported and observed behaviour. Thirty-five percent parents/guardians reported using pea-size toothpaste amount but only 28% were observed. Forty percent reported to brush for 30 s–1 min, however 51% were observed to brush for 1–2 min. Half the children were observed to use fluoridated toothpaste (F < 1000 ppm) under parental supervision (11%). The mean (SD) plaque score reduction after toothbrushing was 10.80 (2.46), mean pre-brushing plaque score was 90.3 (10.2), mean gingival index was 0.89 (0.65) and mean dental caries status (ICDAS(1–6)) was 18.87 (12.39). Toothbrushing behaviour in terms of toothbrushing technique, duration, pattern and frequency, toothbrush type and grip type, toothpaste type and amount, post-brushing mouth rinsing and parental involvement contributed significantly to plaque score change (86%), dental caries status (73%), gingival index (66%) and pre-brushing plaque score (31%). The significant confounding variables had a small influence on oral health of preschool children. Conclusions Preschool children’s toothbrushing behaviour was inadequate while their oral health was poor, with a significant association between the two parameters.

scholarly journals Experience and Prevalence of Dental Caries in 6 to 12-Year-Old School Children in an Agricultural Community: A Cross-Sectional Study

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 99
Author(s):  
Juan José Villalobos-Rodelo ◽  
Martha Mendoza-Rodríguez ◽  
Rosalina Islas-Zarazúa ◽  
Sonia Márquez-Rodríguez ◽  
Mariana Mora-Acosta ◽  
...  
Keyword(s):  
Dental Caries ◽  
School Children ◽  
Cross Sectional Study ◽  
Caries Experience ◽  
Sectional Study ◽  
Caries Prevalence ◽  
Migrant Group ◽  
Cross Sectional ◽  
Agricultural Worker ◽  
Dmft Index

Objective: To describe the experience and prevalence of dental caries in schoolchildren aged 6–12 years belonging to agricultural manual worker households. Material and Methods: A comparative cross-sectional study was conducted in two groups of schoolchildren: One considered “children of agricultural worker migrant parents” (n = 157) and the other “children of agricultural worker non-migrant parents” (n = 164). Epidemiological indices for dental caries were calculated for primary (dmft) and permanent (DMFT) dentitions, and compared in terms of age, sex, and the Simplified Oral Hygiene Index (SOHI). Two binary logistic regression models for caries prevalence in primary and permanent dentitions were generated in Stata. Results: For primary dentition, we observed the following dmft index: Non-migrants = 1.73 ± 2.18 vs. migrants = 1.68 ± 2.14. Additionally, we recorded the following caries prevalence: Non-migrants = 59.1% vs. migrants = 51.3%. For permanent dentition, we observed the following DMFT index: Non-migrants = 0.32 ± 0.81 vs. migrants = 0.29 ± 0.95. Further, we recorded the following caries prevalence: Non-migrants = 17.6% vs. migrants = 12.8%. No differences were observed for either dentition (p > 0.05) in caries indices and their components or in caries prevalence. When both caries indices (dmft and DMFT) were combined, the non-migrant group had a higher level of caries experience than the migrant group (p < 0.05). No relationship (p > 0.05) with migrant status was observed in either multivariate models of caries prevalence. However, age did exhibit an association (p < 0.05) with caries. Only the plaque component of SOHI was associated (p < 0.05) with caries in permanent dentition. Conclusions: Although over half of school children from agricultural manual worker households had caries in either or both dentitions and a considerable proportion were untreated lesions, the prevalence levels were somewhat lower than other reports from Mexico in similar age groups. No statistically significant differences were found in caries experience or prevalence in either dentition between non-migrant and migrant groups.

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