scholarly journals Expression Patterns of Galectin-1 and Galectin-3 in Hibernating Anatolian Ground Squirrel (Spermophilus Xanthoprymnus) Gastrointestinal Tract

2020 ◽  
pp. 1-1
Author(s):  
Mehmet ÖZBEK ◽  
Mustafa ÖZTOP
2019 ◽  
Vol 121 (7) ◽  
pp. 852-865 ◽  
Author(s):  
Mustafa Öztop ◽  
Mehmet Özbek ◽  
Narin Liman ◽  
Feyzullah Beyaz ◽  
Emel Ergün ◽  
...  

2019 ◽  
Vol 43 (4) ◽  
pp. 249-259
Author(s):  
Mustafa Öztop ◽  
Mehmet Özbek ◽  
Feyzullah Beyaz ◽  
Sebahattin Köknur ◽  
Emel Ergün ◽  
...  

2003 ◽  
Vol 129 (6) ◽  
pp. 665 ◽  
Author(s):  
Carine Delbrouck ◽  
Hans-Joachim Gabius ◽  
Herbert Kaltner ◽  
Christine Decaestecker ◽  
Robert Kiss ◽  
...  

2021 ◽  
Vol 3 ◽  
pp. 16-27
Author(s):  
V.T. Sedalishchev ◽  
V.A. Odnokurtsev

Under the influence of environmental factors, in winter-sleeping animals living in extreme winter conditions, a wide range of mechanisms of ecological and physiological adaptations is mani-fested that ensure the normal course of wintering and the survival of populations of species after its end. We carried out an analysis of our own data and literary sources on ecology and endoparasite infestation in three species of rodents – black-capped marmot, Asian long-tailed ground squirrel, Siberian (Asian) chipmunk, and in a representative of predators– brown bear. Data on the distribu-tion of the listed species of hibernating animals in the territory of Yakutia, their reproduction, nutri-tion, the extent of infestation by helminths, hibernation, time of bedding and awakening are given. Before going into hibernation, all hibernating animals reduce their diet and resort to hunger strikes. During this period, liquid and solid excrement is excreted from the body and, together with food waste, helminths leave or destrobilatethe gastrointestinal tract.


2000 ◽  
Vol 85 (1) ◽  
pp. 410-416 ◽  
Author(s):  
Junji Takeyama ◽  
Takashi Suzuki ◽  
Gen Hirasawa ◽  
Yasunari Muramatsu ◽  
Hiroshi Nagura ◽  
...  

The present study investigates the expression patterns of 17β-hydroxysteroid dehydrogenase (17βHSD) isozymes in human fetal tissues to understand how estrogenic activity is regulated in the human fetus. Using enzyme assay, high 17βHSD activity was detected in the placenta and liver, and low levels of 17βHSD activity were also present in the gastrointestinal tract and kidney. After Northern blot analysis, we detected the messenger ribonucleic acid for 17βHSD type 1 (17βHSD1) only in the placenta, whereas that for 17βHSD type 2 (17βHSD2) was detected in the placenta, liver, gastrointestinal tract, and urinary tract at 20 gestational weeks. In RT-PCR analysis of the messenger ribonucleic acid transcripts, 17βHSD1 was predominantly expressed in the placenta, brain, heart, lung, and adrenal, whereas 17βHSD2 expression was predominantly detected in the liver, gastrointestinal tract, and kidney. In addition, we detected 17βHSD2 immunoreactive protein in surface epithelial cells of the stomach, absorptive epithelial cells of the small intestine and colon, hepatocytes of the liver, and interstitial cells surrounding the urinary tubules of the renal medulla. 17βHSD2 in these tissues may be functioning in the prevention of in utero exposure of the fetus to excessive estradiol from the maternal circulation and amniotic fluids.


FEBS Journal ◽  
2007 ◽  
Vol 274 (5) ◽  
pp. 1212-1223 ◽  
Author(s):  
Marie Westerlund ◽  
Andrea Carmine Belin ◽  
Michael R. Felder ◽  
Lars Olson ◽  
Dagmar Galter

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3585
Author(s):  
Wojciech Czogała ◽  
Wojciech Strojny ◽  
Magdalena Schab ◽  
Agnieszka Grabowska ◽  
Karol Miklusiak ◽  
...  

Adipokines and gastrointestinal tract hormones are important metabolic parameters, and both epigenetic factors and differential gene expression patterns may be associated with the alterations in their concentrations in children. The function of the FTO gene (FTO alpha-ketoglutarate dependent dioxygenase) in the regulation of the global metabolic rate is well described, whereas the influence of protooncogene PLAG1 (PLAG1 zinc finger) is still not fully understood. A cross-sectional study on a group of 26 children with various BMI values (15.3–41.7; median 28) was carried out. The aim was to evaluate the dependencies between the level of methylation and expression of aforementioned genes with the concentration of selected gastrointestinal tract hormones and adipokines in children. Expression and methylation were measured in peripheral blood mononuclear DNA by a microarray technique and a restriction enzyme method, respectively. All peptide concentrations were determined using the enzyme immunoassay method. The expression level of both FTO and PLAG1 genes was statistically significantly related to the concentration of adipokines: negatively for apelin and leptin receptor, and positively for leptin. Furthermore, both FTO methylation and expression negatively correlated with the concentration of resistin and visfatin. Cholecystokinin was negatively correlated, whereas fibroblast growth factor 21 positively correlated with methylation and expression of the FTO gene, while FTO and PLAG1 expression was negatively associated with the level of cholecystokinin and glucagon-like peptide-1. The PLAG1 gene expression predicts an increase in leptin and decrease in ghrelin levels. Our results indicate that the FTO gene correlates with the concentration of hormones produced by the adipose tissue and gastrointestinal tract, and PLAG1 gene may be involved in adiposity pathogenesis. However, the exact molecular mechanisms still need to be clarified.


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