scholarly journals Histopathological Effects of Pesticide Imidacloprid Insecticide on the Liver in Male Rabbits

2021 ◽  
Vol 34 (4) ◽  
pp. 1-9
Author(s):  
Ateeq M.J Al-Arami ◽  
Abdulwahab S.M AL-Sanabani
Keyword(s):  
Blood Vessels ◽  
Human Health ◽  
Food Chain ◽  
Digestive System ◽  
Histopathological Changes ◽  
Significant Toxicity ◽  
Study Results ◽  
Neonicotinoid Insecticide ◽  
Oral Doses ◽  
Histopathological Effects

   Excessive use of pesticides has led to increasing concern about undesirable effects on human health and the environment. Imidacloprid is an internationally used neonicotinoid insecticide due to its significant toxicity to insects. Its residues may reach the food chain, which is important for examining the potentially harmful properties of imidacloprid exposure. The current study aimed to characterize the histopathological effects of imidacloprid on the liver of male rabbits. The Imidacloprid administration daily at the two chronic oral doses of (45 mg/kg and 90 mg/kg, daily) for 37 days. Treated male rabbits groups for treatment concentrations revealed many histopathological changes in the liver, such as congestion of blood vessels, hemorrhage, inflammation, ballooned hepatocytes, steatosis, infiltration, vasodilatation, necrosis and fibrosis. The study results established that Imidacloprid was significantly worse in specific organs in the digestive system (liver) of male rabbits.

scholarly journals Some biolochemical and histopathological effects of different oral doses Ochratoxin A in male rats

2012 ◽  
Vol 36 (0E) ◽  
pp. 182-189
Author(s):  
Duraid A. Abbas
Keyword(s):  
Ochratoxin A ◽  
Inflammatory Cells ◽  
Male Rats ◽  
Dependent Manner ◽  
Histopathological Changes ◽  
Oral Doses ◽  
Dose Dependent ◽  
Histopathological Effects ◽  
Alt Activity ◽  
Biochemical Result

The present study was carried out to investigate the effects of Ochratoxin A (OTA) on the serum activity of AST, ALT and ALP, Glutathione (GSH) and liver, kidney and spleen histopathology .Twenty male rats divided equally into three treated groups dosed orally and daily with OTA doses (70, 140 and 210 μg/kg) for 20 day representing T1, T2 and T3 groups and the fourth group dosed daily with distilled water considered as control one. Biochemical result showed elevation in AST and ALT activity and decrease in ALP enzyme activity and GSH serum concentration of treated serum groups at 10 and 20 days of exposure to ochratoxin A these changes positively were proportional with increase OTA doses (dose dependent). Histopathological changes were noticed in liver, kidney and spleen of all treated groups including (necrosis, congestion, and infiltration of inflammatory cells and vacuolation of cytoplasm). The severities of these lesions are in dose dependent manner.

scholarly journals Cyanobacteria, cyanotoxins, and their histopathological effects on fish tissues in Fehérvárcsurgó reservoir, Hungary

2021 ◽  
Vol 193 (9) ◽  
Author(s):  
Damjana Drobac Backović ◽  
Nada Tokodi ◽  
Zoran Marinović ◽  
Jelena Lujić ◽  
Tamara Dulić ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Fish Tissue ◽  
Freshwater Ecosystems ◽  
Abramis Brama ◽  
Histopathological Changes ◽  
Fish Tissues ◽  
The World ◽  
Encoding Gene ◽  
Microcystis Wesenbergii ◽  
Histopathological Effects

AbstractCyanobacteria are important members of lake plankton, but they have the ability to form blooms and produce cyanotoxins and thus cause a number of adverse effects. Freshwater ecosystems around the world have been investigated for the distribution of cyanobacteria and their toxins and the effects they have on the ecosystems. Similar research was performed on the Fehérvárcsurgó reservoir in Hungary during 2018. Cyanobacteria were present and blooming, and the highest abundance was recorded in July (2,822,000 cells/mL). The species present were Aphanizomenon flos-aquae, Microcystis flos-aquae, Microcystis wesenbergii, Cuspidothrix issatschenkoi, Dolichospermum flos-aquae, and Snowella litoralis. In July and September, the microcystin encoding gene mcyE and the saxitoxin encoding gene sxtG were amplified in the biomass samples. While a low concentration of microcystin-RR was found in one water sample from July, analyses of Abramis brama and Carassius gibelio caught from the reservoir did not show the presence of the investigated microcystins in the fish tissue. However, several histopathological changes, predominantly in gills and kidneys, were observed in the fish, and the damage was more severe during May and especially July, which coincides with the increase in cyanobacterial biomass during the summer months. Cyanobacteria may thus have adverse effects in this ecosystem.

Retinal blood vessels detection for diabetic retinopathy with Ridgelet transform and convolution neural network

2020 ◽  
Vol 18 (06) ◽  
pp. 2050048
Author(s):  
Nirmal Yadav
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Blood Vessels ◽  
Machine Learning Algorithms ◽  
Convolution Neural Network ◽  
Transform Method ◽  
Ridgelet Transform ◽  
Study Results

Applying machine learning in life sciences, especially diagnostics, has become a key area of focus for researchers. Combining machine learning with traditional algorithms provides a unique opportunity of providing better solutions for the patients. In this paper, we present study results of applying the Ridgelet Transform method on retina images to enhance the blood vessels, then using machine learning algorithms to identify cases of Diabetic Retinopathy (DR). The Ridgelet transform provides better results for line singularity of image function and, thus, helps to reduce artefacts along the edges of the image. The Ridgelet Transform method, when compared with earlier known methods of image enhancement, such as Wavelet Transform and Contourlet Transform, provided satisfactory results. The transformed image using the Ridgelet Transform method with pre-processing quantifies the amount of information in the dataset. It efficiently enhances the generation of features vectors in the convolution neural network (CNN). In this study, a sample of fundus photographs was processed, which was obtained from a publicly available dataset. In pre-processing, first, CLAHE was applied, followed by filtering and application of Ridgelet transform on the patches to improve the quality of the image. Then, this processed image was used for statistical feature detection and classified by deep learning method to detect DR images from the dataset. The successful classification ratio was 98.61%. This result concludes that the transformed image of fundus using the Ridgelet Transform enables better detection by leveraging a transform-based algorithm and the deep learning.

A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health

2020 ◽  
Vol 22 (6) ◽  
pp. 1315-1346 ◽  
Author(s):  
Darrin A. Thompson ◽  
Hans-Joachim Lehmler ◽  
Dana W. Kolpin ◽  
Michelle L. Hladik ◽  
John D. Vargo ◽  
...  
Keyword(s):  
Human Health ◽  
Health Risks ◽  
Critical Review ◽  
Human Exposure ◽  
Environmental Fate ◽  
Current Knowledge ◽  
Neonicotinoid Insecticides ◽  
Neonicotinoid Insecticide

The review examines literature relevant to environmental fate, transformation, and toxicity, and human exposure and health risks of neonicotinoid insecticides.

scholarly journals Cardiovascular and hematologic effects produced by chronic treatment with etoricoxib in normotensive rats

2009 ◽  
Vol 24 (3) ◽  
pp. 206-210 ◽  
Author(s):  
Nilo César do Vale Baracho ◽  
Guilherme Pedrosa Guizelli ◽  
Beatriz Leone Carmello ◽  
Danielle de Souza Sanches ◽  
Felipe Moraes Costa Silva ◽  
...  
Keyword(s):  
Blood Cells ◽  
Chronic Treatment ◽  
Experimental Period ◽  
Control Group ◽  
Histopathological Changes ◽  
Study Results ◽  
Significant Difference ◽  
Hematological Effects ◽  
The Mean ◽  
Hematological Changes

PURPOSE: Evaluate the cardiovascular and hematological effects produced by chronic treatment with two dosis of etoricoxib in Wistar normotensive rats. METHODS: Thirty rats have been used and divided into one control group and two etoricoxib (10mg/kg and 30mg/kg) treatments groups for 60 days. The mean arterial pressure (MAP) was taken during the whole experimental period and at the end of this period, under anesthesia blood samples were taken, and further the withdrawn of the aorta, heart, brain, liver, and kidneys for the anatomopathologic study. RESULTS: The treatment with etoricoxib (30mg/Kg) produced a significant increase of the MAP from the 28th day of the experiment and from the platelets when compared to the control group and to the group treated with 10mg/Kg, besides producing a highly significant difference in hematocrit and in the red blood cells in relation to the control group. On the other hand the treatment with etoricoxib has not caused histopathological changes when compared to the control. CONCLUSION: These data show that the chronic treatment with etoricoxib leads to increase of the MAP, and to important hematological changes which seem to be associated to the hemoconcentration although not producing anatomopathological significant changes.

scholarly journals A Review of the Impact of Selected Anthropogenic Chemicals from the Group of Endocrine Disruptors on Human Health

Toxics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 146
Author(s):  
Katarzyna Goralczyk
Keyword(s):  
Human Health ◽  
Endocrine Disruptors ◽  
Digestive System ◽  
Meta Analysis ◽  
Holistic Approach ◽  
Public Healthcare ◽  
Endocrine Activity ◽  
Daily Lives ◽  
Food Packages ◽  
The Impact

Background: The aim of the study was to review data on the impact of anthropogenic chemicals (endocrine disruptors) on various diseases, which, consequently, may facilitate their prevention and be used as a tool for managing public healthcare. Every day, humans are exposed to chemicals, including xenoestrogens, which are similar to female hormones. Methods: This manuscript was prepared based on a meta-analysis of research on the impacts of selected EDCs on human health. Results: Special attention should be paid to bisphenol A (BPA), benzo-α-pyrene, and phthalates due to their proven endocrine activity and presence in our daily lives. Xenoestrogens are absorbed by human organisms through the digestive system since they can migrate to food from food packages and drinks as well as from plastic products used daily. The presence of these chemicals in human organisms is considered a potential cause for some diseases commonly referred to as ‘diseases of civilization’. Conclusions: The biomonitoring of xenoestrogens, which are chemicals with unfavorable impacts on human health, is a crucial tool for assessing the risk from the pollution of the environment. The novelty is a holistic approach to assessing the occurrence of risk factors for civilization diseases.

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