A Research Domain Criteria (RDoC) approach to Gambling Disorder: focus on preference-based decision-making and response inhibition

2018 ◽  
Vol 01 (01) ◽  
Author(s):  
A. Marras ◽  
N. Makris
Keyword(s):  
Decision Making ◽  
Response Inhibition ◽  
Gambling Disorder ◽  
Research Domain Criteria ◽  
Research Domain

Positive Mood States and Gambling Disorder

2019 ◽  
pp. 366-379
Author(s):  
Sarah W. Yip ◽  
Zu Wei Zhai ◽  
Iris M. Balodis ◽  
Marc N. Potenza
Keyword(s):  
Impulse Control ◽  
Gambling Disorder ◽  
Adult Population ◽  
Approach Motivation ◽  
Gambling Problems ◽  
Research Domain Criteria ◽  
Monetary Rewards ◽  
Neuroimaging Data ◽  
Positive Valence ◽  
Research Domain

Gambling problems are experienced by about 1% of the adult population, with higher estimates reported in adolescents. Both positive and negative motivations for gambling exist and may contribute to gambling problems. Positive valence disturbances involving how people process rewards, including monetary rewards relevant to gambling, have been reported in gambling disorder and have been associated with the disorder and clinically relevant measures relating to impaired impulse control. Positive valence systems as they relate to gambling disorder and clinically relevant features thereof are considered in this chapter. Findings from neuroimaging data related to the positive valence system constructs of approach motivation, initial and sustained/longer term responsiveness to reward, habit and reward learning are reviewed. Possible interactions between positive valence systems and other Research Domain Criteria (RDoC) systems are also discussed within the context of gambling disorder, as is how the application of an RDoC framework can be used to further understanding of gambling disorder.

scholarly journals A Research Domain Criteria Approach to Gambling Disorder and Behavioral Addictions: Decision-Making, Response Inhibition, and the Role of Cannabidiol

2021 ◽  
Vol 12 ◽  
Author(s):  
Stefano Pallanti ◽  
Anna Marras ◽  
Nikolaos Makris
Keyword(s):  
Gambling Disorder ◽  
Substance Dependence ◽  
Endocannabinoid System ◽  
Behavioral Addictions ◽  
Psychoactive Substance ◽  
Research Domain Criteria ◽  
Addictive Disorders ◽  
Substance Addiction ◽  
Positive Valence ◽  
Research Domain

Gambling Disorder (GD) has been recently re-classified in the DSM-5 under the “substance-related and addictive disorders,” in light of its genetic, endophenotypic, and phenotypic resemblances to substance dependence. Diminished control is a core defining concept of psychoactive substance dependence or addiction and has given rise to the concept of “behavioral” addictions, which are syndromes analogous to substance addiction, but with a behavioral focus other than ingestion of a psychoactive substance. The main symptom clusters are represented by loss of control, craving/withdrawal, and neglect of other areas of life, whereas in a Research Domain Criteria (RDoC) perspective, GD patients exhibit deficits in the domain of “Positive valence systems,” particularly in the “Approach motivation” and “Reward learning” constructs, as well as in the “Cognitive systems,” primarily in the “Cognitive control” construct. In the Addictions Neuroclinical Assessment (ANA), three relevant domains for addictions emerge: “Incentive salience,” “Negative Emotionality,” and “Executive Function.” The endocannabinoid system (ECS) may largely modulate these circuits, presenting a promising pharmaceutical avenue for treating addictions. Up to now, research on cannabidiol has shown some efficacy in Attention Deficit/Hyperactivity Disorder (ADHD), whereas in behavioral addictions its role has not been fully elucidated, as well as its precise action on RDoC domains. Herein, we review available evidence on RDoC domains affected in GD and behavioral addictions and summarize insights on the use of cannabidiol in those disorders and its potential mechanisms of action on reward, decisional, and sensorimotor processes.

The neural basis of cognitive control in gambling disorder: A systematic review of fMRI studies

2017 ◽  
Vol 41 (S1) ◽  
pp. s870-s871
Author(s):  
L. Moccia ◽  
M. Pettorruso ◽  
L. De Risio ◽  
F. De Crescenzo ◽  
L. Di Nuzzo ◽  
...  
Keyword(s):  
Decision Making ◽  
Cognitive Control ◽  
Cognitive Flexibility ◽  
Response Inhibition ◽  
Gambling Disorder ◽  
Emotional Processing ◽  
Self Report ◽  
Conflict Monitoring ◽  
Neural Basis ◽  
Competing Interest

IntroductionDecreased cognitive control over the urge to be involved in gambling activities is a core feature of gambling disorder (GD). Cognitive control can be conceptualized as the sum of high-order cognitive faculties interacting in the achievement of goal-oriented behaviors. As such, cognitive control can be differentiated into several cognitive sub-processes, such as response inhibition, conflict monitoring, decision-making and cognitive flexibility, all of which prove to be pivotal in GD clinical phenomenology.ObjectivesOver the past few years, several studies and reviews have indicated a lack of cognitive control in GD through self-report questionnaires and neurocognitive tasks. Conversely, there are only a limited number of neuroimaging studies, which investigate the neural mechanisms underlying diminished cognitive control in GD.AimsThis research aims to systematically review functional magnetic resonance imaging (fMRI) studies that target cognitive control in GD.MethodsA literature search was conducted in order to find appropriate published articles on fMRI studies in GD.ResultsFourteen fMRI studies were included. Depending on which neurocognitive task was employed, the studies were divided into five different sections: conflict monitoring, response inhibition, delay discounting, cognitive flexibility and decision-making.ConclusionsImpaired activity in prefrontal cortex may account for decreased cognitive control in GD, contributing to the progressive loss of control over gambling behaviors. However, the way in which cognitive control interacts with affective and motivational processes in GD is still matter of investigation. Among prefrontal areas, orbitofrontal cortex has been indicated as a possible nexus for sensory integration, value-based decision-making and emotional processing, thus contributing to both motivational and affective aspects of cognitive control.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Challenges of Fear Conditioning Research in the Age of RDoC

2017 ◽  
Vol 225 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Tina B. Lonsdorf ◽  
Jan Richter
Keyword(s):  
Fear Conditioning ◽  
Clinical Diagnosis ◽  
Research Domain Criteria ◽  
Major Focus ◽  
The Future ◽  
Definition Of ◽  
Methodological Considerations ◽  
Research Domain

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.

The Psychophysiology of Anxiety and Mood Disorders

2017 ◽  
Vol 225 (3) ◽  
pp. 175-188 ◽  
Author(s):  
Peter J. Lang ◽  
Lisa M. McTeague ◽  
Margaret M. Bradley
Keyword(s):  
Mental Health ◽  
Heart Rate ◽  
Brain Function ◽  
Physiological Reactivity ◽  
Research Domain Criteria ◽  
Diagnostic Systems ◽  
Psychophysiological Reactivity ◽  
Diagnostic Categories ◽  
New Research ◽  
Research Domain

Abstract. Several decades of research are reviewed, assessing patterns of psychophysiological reactivity in anxiety patients responding to a fear/threat imagery challenge. Findings show substantive differences in these measures within principal diagnostic categories, questioning the reliability and categorical specificity of current diagnostic systems. Following a new research framework (US National Institute of Mental Health [NIMH], Research Domain Criteria [RDoC]; Cuthbert & Insel, 2013 ), dimensional patterns of physiological reactivity are explored in a large sample of anxiety and mood disorder patients. Patients’ responses (e.g., startle reflex, heart rate) during fear/threat imagery varied significantly with higher questionnaire measured “negative affect,” stress history, and overall life dysfunction – bio-marking disorder groups, independent of Diagnostic and Statistical Manuals (DSM). The review concludes with a description of new research, currently underway, exploring brain function indices (structure activation, circuit connectivity) as potential biological classifiers (collectively with the reflex physiology) of anxiety and mood pathology.

Trauma and mood disorders: comorbidity with post-traumatic stress disorder or overlapping symptoms?

2016 ◽  
Vol Ano 6 ◽  
pp. 38-42
Author(s):  
Andrea Feijó Mello ◽  
Euthymia B. Almeida Prado
Keyword(s):  
Mood Disorders ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Research Domain Criteria ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Research Domain

O presente artigo discorre sobre a comorbidade entre transtorno bipolar (TB) e transtorno de estresse póstraumático (TEPT) e questiona sobre certos casos serem melhor avaliados à luz das novas teorias do Research Domain Criteria (RDoC), principalmente aqueles quadros de TEPT com sintomas disfóricos que podem ser classificados como TB, apesar de não preencherem critérios para tal. Nesse caso, questiona-se a comorbidade e propõe-se um aprofundamento da fisiopatologia dessa sintomatologia que está sobreposta. Clinicamente, esse olhar poderá facilitar o manejo farmacológico de pacientes graves com histórico de trauma.

scholarly journals Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model

2021 ◽  
pp. 1-10
Author(s):  
Melody R. Altschuler ◽  
Robert F. Krueger
Keyword(s):  
Personality Disorders ◽  
Personality Pathology ◽  
Integrative Model ◽  
Research Domain Criteria ◽  
Developmental Context ◽  
Dimensional Classification ◽  
Developmental Theories ◽  
Underlying Mechanisms ◽  
Research Domain

Abstract Traditional categorical approaches to classifying personality disorders are limited in important ways, leading to a shift in the field to dimensional approaches to conceptualizing personality pathology. Different areas of psychology – personality, developmental, and psychopathology – can be leveraged to understand personality pathology by examining its structure, development, and underlying mechanisms. However, an integrative model that encompasses these distinct lines of inquiry has not yet been proposed. In order to address this gap, we review the latest evidence for dimensional classification of personality disorders based on structural models of maladaptive personality traits, provide an overview of developmental theories of pathological personality, and summarize the Research Domain Criteria (RDoC) initiative, which seeks to understand underlying mechanisms of psychopathology. We conclude by proposing an integrative model of personality pathology development that aims to elucidate the developmental pathways of personality pathology and its underlying mechanisms.

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