scholarly journals Novel Mercaptan Derivatives Nanogold Particles with Hyperchromic and Fluorescence Sensitization Effects

2016 ◽  
Author(s):  
Dorothy Araba Yakoba Agyapon ◽  
Ran-Lin Zhao ◽  
Cai-Xia Li ◽  
Wen-Ju Du ◽  
Hong-Juan Zeng
Keyword(s):  
Nanogold Particles ◽  
Fluorescence Sensitization

scholarly journals Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 143 ◽  
Author(s):  
Jingnan Zhao
Keyword(s):  
Hyaluronic Acid ◽  
Inflammatory Cells ◽  
Oxygen Species ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Nanogold Particles ◽  
Gold Nanocages ◽  
Factor Alpha ◽  
Anti Inflammatory ◽  
Necrosis Factor

Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. HA-AuNCs/T/P show a much higher intracellular uptake than AuNCs/T/P, and exhibit a much higher efficacy on the suppression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) than free TPCA-1, suggesting great improvement to the anti-inflammatory efficacy of TPCA-1 through the application of AuNCs. HA-AuNCs/T/P can also reduce the production of reactive oxygen species in inflammatory cells. This study suggests that HA-AuNCs/T/P may be potential agents for anti-inflammatory treatment, and are worthy of further investigation.

scholarly journals pHLIP peptide targets nanogold particles to tumors

2012 ◽  
Vol 110 (2) ◽  
pp. 465-470 ◽  
Author(s):  
L. Yao ◽  
J. Daniels ◽  
A. Moshnikova ◽  
S. Kuznetsov ◽  
A. Ahmed ◽  
...  
Keyword(s):  
Nanogold Particles

scholarly journals Nanogold as a Specific Marker for Electron Cryotomography

2009 ◽  
Vol 15 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Yongning He ◽  
Grant J. Jensen ◽  
Pamela J. Bjorkman
Keyword(s):  
Lipid Bilayers ◽  
Outer Surface ◽  
Three Dimensional ◽  
Fc Receptor ◽  
Specific Marker ◽  
Neonatal Fc Receptor ◽  
Membrane Bound ◽  
Nanogold Particles ◽  
Intracellular Vesicles ◽  
Electron Cryotomography

AbstractWhile electron cryotomography (ECT) provides “molecular” resolution, three-dimensional images of unique biological specimens, sample crowdedness, and/or resolution limitations can make it difficult to identify specific macromolecular components. Here we used a 1.4 nm Nanogold® cluster specifically attached to the Fc fragment of IgG to monitor its interaction with the neonatal Fc receptor (FcRn), a membrane-bound receptor that transports IgG across cells in acidic intracellular vesicles. ECT was used to image complexes formed by Nanogold-labeled Fc bound to FcRn attached to the outer surface of synthetic liposomes. In the resulting three-dimensional reconstructions, 1.4 nm Nanogold particles were distributed predominantly along the interfaces where 2:1 FcRn-Fc complexes bridged adjacent lipid bilayers. These results demonstrate that the 1.4 nm Nanogold cluster is visible in tomograms of typically thick samples (∼250 nm) recorded with defocuses appropriate for large macromolecules and is thus an effective marker.

Evaluation of nanogold particles-based enzyme-linked immunosorbent assay for detection of hydatidosis

2018 ◽  
Vol 35 (2) ◽  
pp. 134
Author(s):  
AmiraS ElGhannm ◽  
SamiaM Rashed ◽  
MonaE Naser ◽  
IbrahimR Bayoumi ◽  
NagwaS.M. Aly ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nanogold Particles

scholarly journals Establishment of Fluorescence Sensitization Method for Hydroxysafflor Yellow A

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
CAO Haiyan ◽  
QIN Xiude ◽  
LIU Chen ◽  
ZHAO Xinzhe ◽  
MA Yuhui ◽  
...  
Keyword(s):  
Detection Limit ◽  
Fluorescence Intensity ◽  
Fluorescence Spectra ◽  
Pharmacological Effects ◽  
Absorption And Fluorescence Spectra ◽  
Hydroxysafflor Yellow A ◽  
T24 Cells ◽  
Fluorescence Sensitization ◽  
In Cells

As the main active ingredient in Chinese medicine safflower, hydroxysafflor yellow A (HSYA) has multiple pharmacological effects. In the work, the absorption and fluorescence spectra of HSYA under different environmental conditions (such as acidity, temperature, ions, viscosity, and surfactant) were investigated. The fluorescence intensity of HSYA varied greatly with acidity, temperature, viscosity, and surfactant, but was less affected by common cations and anions. Among various surfactants, we found that borax can significantly enhance the HSYA fluorescence intensity, and thus, a borax-HSYA sensitization system for HSYA fluorescence was established. In the optimized sensitization system, the fluorescence intensity of HSYA increased by 20 times and showed a good linearity with HSYA concentrations in the range of 0∼10 μM with a detection limit of 8 nM. The borax-HSYA sensitization system is nontoxic to T24 cells and mice and can be used for the fluorescence imaging of HSYA in cells, thereby providing an effective method for analyzing HSYA in vitro and monitoring its metabolism in cells.

Remediation of Wastewater from Chlorpyrifos Pesticide by Nano-Gold Photocatalyst

MRS Advances ◽  
2020 ◽  
Vol 5 (52-53) ◽  
pp. 2661-2667 ◽  
Author(s):  
Puja Goel ◽  
Manju Arora
Keyword(s):  
Functional Group ◽  
Localized Surface Plasmon ◽  
Surface Plasmon Resonance Peak ◽  
Transmission Spectra ◽  
Plasmon Resonance Peak ◽  
Color Changes ◽  
Nano Gold ◽  
Absorption Studies ◽  
Ir Transmission ◽  
Nanogold Particles

AbstractSuccessful disintegration of Chlorpyrifos pesticide by nearly monodisperse nano-gold photcatalyst (∼10 nm) for remediation of wastewater has been reported in current studies. Nano-Gold dispersion reaction with Chlorpyrifos solutions completes in 45 minutes at ambient temperature under the normal daylight and exhibit systematic variations in the solution color from wine red to pink to light sky blue and finally transforming into a transparent solution with fine precipitates. UV-Vis absorption studies correlates well with the systematic color changes as observed in the nano-gold treated Chlorpyrifos solutions with time. The characteristic localized surface plasmon resonance peak of nanogold dispersion observed at 529 nm red shifts to weak, medium and strong intensity peaks at ∼ 640 nm, 740 nm and 890 nm on increasing chlorpyrifos concentration owing to the aggregation of gold nanoparticles in small to bigger sized clusters. The fine turbidity in final transparent solution further confirms the aggregation of nanogold particles into stable bigger ensembles. IR transmission spectra of final transparent solutions showed disappearance of Chlorpyrifos νC-Cl and phosphorothioate functional group peaks indicating degradation of chlorpyrifos.

Double-codified nanogold particles based automated flow-through CLEIA for 2,4-dinitrotoluene

2010 ◽  
Vol 2 (7) ◽  
pp. 824 ◽  
Author(s):  
Zhen Lin ◽  
J. C. Sauceda-Friebe ◽  
Jin-Ming Lin ◽  
Reinhard Niessner ◽  
Dietmar Knopp
Keyword(s):  
Nanogold Particles ◽  
Flow Through
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