scholarly journals Injury Difference of the Un-Aggregated and Aggregated Calcium Oxalate Monohydrate on Human Kidney Proximal Tubular Epithelial Cells

2017 ◽  
Author(s):  
Li-shan HUANG ◽  
Da GUO ◽  
Jian-ming OUYANG
Keyword(s):  
Epithelial Cells ◽  
Calcium Oxalate ◽  
Human Kidney ◽  
Calcium Oxalate Monohydrate ◽  
Tubular Epithelial Cells ◽  
Proximal Tubular Epithelial Cells ◽  
Proximal Tubular

Effects of Oxalate 0n HK-2 Cells, a Line of Proximal Tubular Epithelial Cells From Normal Human Kidney

2002 ◽  
pp. 253-259 ◽  
Author(s):  
AKSHAY BHANDARI ◽  
SWEATY KOUL ◽  
AVTAR SEKHON ◽  
SAROJ K. PRAMANIK ◽  
LAKSHMI S. CHATURVEDI ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Human Kidney ◽  
Tubular Epithelial Cells ◽  
Normal Human Kidney ◽  
Proximal Tubular Epithelial Cells ◽  
Proximal Tubular ◽  
Normal Human

Transdifferentiation of Distal but Not Proximal Tubular Epithelial Cells from Human Kidney in Culture

1999 ◽  
Vol 7 (4) ◽  
pp. 306-313 ◽  
Author(s):  
Patrick C. Baer ◽  
Ulf W. Tunn ◽  
German Nunez ◽  
Jürgen E. Scherberich ◽  
Helmut Geiger
Keyword(s):  
Epithelial Cells ◽  
Human Kidney ◽  
Tubular Epithelial Cells ◽  
Proximal Tubular Epithelial Cells ◽  
Proximal Tubular

DONOR-SPECIFIC LYSIS OF HUMAN KIDNEY PROXIMAL TUBULAR EPITHELIAL CELLS BY RENAL ALLOGRAFT-INFILTRATING LYMPHOCYTES

1989 ◽  
Vol 48 (2) ◽  
pp. 296-301 ◽  
Author(s):  
A. M. M. MILTENBURG ◽  
M. E. MEIJER-PAAPE ◽  
M. R. DAHA ◽  
J. H. VAN BOCKEL ◽  
J. J. WEENING ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Renal Allograft ◽  
Human Kidney ◽  
Tubular Epithelial Cells ◽  
Specific Lysis ◽  
Proximal Tubular Epithelial Cells ◽  
Proximal Tubular ◽  
Infiltrating Lymphocytes

scholarly journals Total flavones of Desmodium styracifolium antagonize calcium oxalate monohydrate-triggered IL-2Rβ expression in renal epithelial cells

2021 ◽  
Vol 18 (5) ◽  
pp. 1077-1081
Author(s):  
Haijie Xie ◽  
Rui Yang ◽  
Yong Xu ◽  
Chunyu Liu
Keyword(s):  
Epithelial Cells ◽  
Western Blot ◽  
Calcium Oxalate ◽  
Human Kidney ◽  
Calcium Oxalate Monohydrate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dependent Manner ◽  
Renal Epithelial Cells ◽  
Desmodium Styracifolium ◽  
Proximal Tubular

Purpose: To explore the effect of total flavone of Desmodium styracifolium (TFDS) on calcium oxalate monohydrate (COM)-triggered IL-2Rβ expression in human kidney proximal tubular epithelial cells. Methods: Human kidney proximal tubular epithelial cell line HK-2 was treated with COM, TFDS or both. The expression of IL-2Rβ was evaluated by quantitative polymerase chain reaction (qPCR) or flow cytometry. The responsiveness of HK-2 cells to IL-2 was determined by enzyme-linked immunosorbent assay (ELISA), qPCR and western blot. The signaling mechanism underlying the effect of TFDS was studied using western blot and qPCR. The clinical relevance of IL-2Rβ to renal inflammation was investigated by re-analyzing a Gene Expression Omnibus (GEO) dataset. Results: Total flavones of Desmodium styracifolium (TFDS) antagonize COM-triggered IL-2Rβ expression in HK-2 cells, thus reducing the responsiveness of HK-2 cells to IL-2 stimulation. Mechanistically, TFDS dampens IL-2Rβ expression by preventing the activation of STAT3. The level of IL-2Rβ is positively correlated with the inflammatory status of the kidney. Conclusions: The total flavones of Desmodium styracifolium (TFDS) prevent the upregulation of IL2Rβ in renal epithelial cells upon COM stimulation in a STAT3-dependent manner.

Effects of Oxalate 0n HK-2 Cells, a Line of Proximal Tubular Epithelial Cells From Normal Human Kidney

2002 ◽  
Vol 168 (1) ◽  
pp. 253-259 ◽  
Author(s):  
Akshay Bhandari ◽  
Sweaty Koul ◽  
Avtar Sekhon ◽  
Saroj K. Pramanik ◽  
Lakshmi S. Chaturvedi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Human Kidney ◽  
Tubular Epithelial Cells ◽  
Normal Human Kidney ◽  
Proximal Tubular Epithelial Cells ◽  
Proximal Tubular ◽  
Normal Human
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