scholarly journals To Manage Both Thoracic Surgeon and Basic Research of Cancer Immunotherapy

2021 ◽  
Vol 71 (3) ◽  
pp. 219-220
Author(s):  
Toshiki Yajima
Keyword(s):  
Cancer Immunotherapy ◽  
Basic Research ◽  
Thoracic Surgeon

scholarly journals Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions

2020 ◽  
Vol Volume 12 ◽  
pp. 10411-10421
Author(s):  
Guoming Zeng ◽  
Libo Jin ◽  
Qinsi Ying ◽  
Haojie Chen ◽  
Murinda Charmaine Thembinkosi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cancer Immunotherapy ◽  
Basic Research ◽  
Research Outcomes

Immunotherapy and tumour resistance to immune-mediated control and elimination

2019 ◽  
pp. 423-437
Author(s):  
Gwennaëlle C. Monnot ◽  
Pedro Romero
Keyword(s):  
Immune System ◽  
Cancer Immunotherapy ◽  
Cancer Patients ◽  
Basic Research ◽  
Tumour Microenvironment ◽  
Experimental Models ◽  
Dynamic Interactions ◽  
Tumour Control ◽  
Therapeutic Modalities ◽  
Main Components

The field of tumour immunology has gradually reached a consensus that the immune system and tumours sustain a rich set of dynamic interactions starting early during carcinogenesis. Incipient tumours may be eliminated by the immune system via adaptive immune responses mediated mainly by cytotoxic CD8 T lymphocytes, which recognize short antigenic peptides presented by polymorphic major histocompatibility complex (MHC) class I molecules. Advanced tumours, however, are generally highly resistant to the main effectors of the immune system. Moreover, the molecular and cellular composition of the tumour microenvironment is strongly immunosuppressive. Recent research efforts have focused on the dissection of the mechanisms operating at the tumour sites, which neutralize antitumour immunity in both experimental models and directly in cancer patients. All along this basic research, translational scientists have tried to harness the immune system to design novel therapeutic modalities that have collectively been coined as cancer immunotherapy. The overall goal has been to increase the numbers of tumour antigen-specific T cells in cancer patients via either vaccination or adoptive transfer of large numbers of immune cells. It is safe to state that cancer immunotherapy will provide a revolution in the treatment of cancer and the future may bear the prospect of effective tumour control in many cancer types, and that immunotherapy will be one of the main components of effective therapeutic options.

A New 1,000 kV Electron Microscope

1967 ◽  
Vol 25 ◽  
pp. 260-261
Author(s):  
M. Nishigaki ◽  
S. Katagiri ◽  
H. Kimura ◽  
B. Tadano
Keyword(s):  
Electron Microscope ◽  
High Voltage ◽  
Basic Research ◽  
Chromatic Aberration ◽  
High Accuracy ◽  
Biological Specimen ◽  
Voltage Electron ◽  
High Voltage Electron Microscope ◽  
High Voltage Electron

The high voltage electron microscope has many advantageous features in comparison with the ordinary electron microscope. They are a higher penetrating efficiency of the electron, low chromatic aberration, high accuracy of the selected area diffraction and so on. Thus, the high voltage electron microscope becomes an indispensable instrument for the metallurgical, polymer and biological specimen studies. The application of the instrument involves today not only basic research but routine survey in the various fields. Particularly for the latter purpose, the performance, maintenance and reliability of the microscope should be same as those of commercial ones. The authors completed a 500 kV electron microscope in 1964 and a 1,000 kV one in 1966 taking these points into consideration. The construction of our 1,000 kV electron microscope is described below.

An emerging technology: Nuclear magnetic resonance microscopy

1988 ◽  
Vol 46 ◽  
pp. 1000-1001
Author(s):  
M.J. Hennessy ◽  
E. Kwok
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
Basic Research ◽  
Local Environment ◽  
Magnetic Resonance Images ◽  
Nmr Microscopy ◽  
Mri Scans ◽  
Temperature Relaxation ◽  
Nuclear Magnetic

Much progress in nuclear magnetic resonance microscope has been made in the last few years as a result of improved instrumentation and techniques being made available through basic research in magnetic resonance imaging (MRI) technologies for medicine. Nuclear magnetic resonance (NMR) was first observed in the hydrogen nucleus in water by Bloch, Purcell and Pound over 40 years ago. Today, in medicine, virtually all commercial MRI scans are made of water bound in tissue. This is also true for NMR microscopy, which has focussed mainly on biological applications. The reason water is the favored molecule for NMR is because water is,the most abundant molecule in biology. It is also the most NMR sensitive having the largest nuclear magnetic moment and having reasonable room temperature relaxation times (from 10 ms to 3 sec). The contrast seen in magnetic resonance images is due mostly to distribution of water relaxation times in sample which are extremely sensitive to the local environment.

Mother-to-child transmission of HIV: developing integration of healthcare programmes with clinical, social and basic research studies

2003 ◽  
Vol 92 (11) ◽  
pp. 1343-1348
Author(s):  
Menu E ◽  
Scarlatti G ◽  
Barré-Sinoussi F ◽  
Gray G ◽  
Bollinger B ◽  
...  
Keyword(s):  
Basic Research ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Research Studies

The Multiple Faces of Risk-Taking

2016 ◽  
Vol 32 (1) ◽  
pp. 17-38 ◽  
Author(s):  
Florian Schmitz ◽  
Karsten Manske ◽  
Franzis Preckel ◽  
Oliver Wilhelm
Keyword(s):  
Risk Taking ◽  
Basic Research ◽  
Formal Models ◽  
Experimental Paradigm ◽  
Nomological Network ◽  
Balloon Analogue Risk Task ◽  
Parameter Recovery ◽  
Task Specificity ◽  
Available Information ◽  
Criterion Variables

Abstract. The Balloon-Analogue Risk Task (BART; Lejuez et al., 2002 ) is one of the most popular behavioral tasks suggested to assess risk-taking in the laboratory. Previous research has shown that the conventionally computed score is predictive, but neglects available information in the data. We suggest a number of alternative scores that are motivated by theories of risk-taking and that exploit more of the available data. These scores can be grouped around (1) risk-taking, (2) task performance, (3) impulsive decision making, and (4) reinforcement sequence modulation. Their theoretical rationale is detailed and their validity is tested within the nomological network of risk-taking, deviance, and scholastic achievement. Two multivariate studies were conducted with youths (n = 435) and with adolescents/young adults (n = 316). Additionally, we tested formal models suggested for the BART that decompose observed behavior into a set of meaningful parameters. A simulation study with parameter recovery was conducted, and the data from the two studies were reanalyzed using the models. Most scores were reliable and differentially predictive of criterion variables and may be used in basic research. However, task specificity and the generally moderate validity do not warrant use of the experimental paradigm for diagnostic purposes.

NIMH and Basic Research

1972 ◽  
Vol 17 (3) ◽  
pp. 146-147
Author(s):  
THOMAS S. HYDE
Keyword(s):  
Basic Research

The Basis of Basic Research

1960 ◽  
Vol 5 (9) ◽  
pp. 300-301
Author(s):  
WALTER A. ROSENBLITH
Keyword(s):  
Basic Research
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