scholarly journals A Case of Early Gastric Cancer Producing Alpha-Fetoprotein with Local Recurrence at a Relatively Early Stage after Laparoscopy-Assisted Distal Gastrectomy

2011 ◽  
Vol 61 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Norifumi Takahashi ◽  
Toshihiro Ohya ◽  
Hiroshi Matsumoto ◽  
Kenichi Tago ◽  
Ken Muroya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Local Recurrence ◽  
Distal Gastrectomy ◽  
Early Stage ◽  
Alpha Fetoprotein

scholarly journals Alpha-Fetoprotein-Producing Early Gastric Cancer with Intramucosal Hepatoid and Fetal Enteric Differentiation

2020 ◽  
Vol 14 (2) ◽  
pp. 426-435
Author(s):  
Mai Iwaya ◽  
Robert Riddell ◽  
Koji Asano ◽  
Kazuo Kobayashi ◽  
Takeshi Uehara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Early Gastric Cancer ◽  
Tumor Invasion ◽  
Early Stage ◽  
Previous History ◽  
Alpha Fetoprotein ◽  
Arginase 1 ◽  
History Of ◽  
Intramucosal Adenocarcinoma

Alpha-fetoprotein (AFP)-producing gastric carcinomas (AFPGCs) are relatively rare tumors known to have a poor prognosis and commonly found as advanced lesions. Histologically, AFPGCs have been described as having hepatoid and fetal enteric (enteroblastic) morphology and are associated with conventional adenocarcinomas. Prior studies reported a hepatoid component present only in invasive areas and hypothesized that AFPGCs may develop hepatoid features during the process of tumor invasion. We report three cases of AFP-producing early gastric cancer which had an intramucosal hepatoid component. Immunohistochemistry showed that the hepatoid component was diffusely immunoreactive for SALL4, AFP, arginase-1, and HepPar1, and focally for CDX2 and PDX1. An intramucosal transition between the hepatoid component and conventional intramucosal adenocarcinoma was identified. Two patients also had a coexistent fetal enteric component, which was admixed with a hepatoid component. Although at an early stage one patient subsequently developed liver metastasis and a second patient was suspected of having liver metastasis, these were not biopsy-proven. The latter patient had a previous history of hepatocellular carcinoma (HCC) and SALL4 was used on the HCC to distinguish metastatic/further HCC from a gastric metastatic primary with hepatoid differentiation.

Evaluation of Hand-Assisted Laparoscopic Distal Gastrectomy for Patients with Early Gastric Cancer

2003 ◽  
Vol 52 (4) ◽  
pp. 717-725
Author(s):  
Yoshibumi NIITSUMA ◽  
Tsuneo KAWASAKI ◽  
Hajime TSUKUI ◽  
Yoshinobu TAKAHASHI ◽  
Masamitsu MAEDA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Distal Gastrectomy ◽  
Laparoscopic Distal Gastrectomy

Alpha-Fetoprotein-Producing Early Gastric Cancer of the Remnant Stomach: Report of a Case

Surgery Today ◽  
2007 ◽  
Vol 37 (11) ◽  
pp. 995-999 ◽  
Author(s):  
Yutaka Shibata ◽  
Kouhei Sato ◽  
Masashi Kodama ◽  
Hiroshi Nanjyo
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Remnant Stomach ◽  
Alpha Fetoprotein

scholarly journals Diagnostic value of macrophage inhibitory cytokine 1 as a novel prognostic biomarkers for early gastric cancer screening

2020 ◽  
Author(s):  
Xin Ge ◽  
Xiaolei Zhang ◽  
Yanling Ma ◽  
Shaohua Chen ◽  
Zhaowu Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Precancerous Lesions ◽  
Diagnostic Value ◽  
Low Grade ◽  
Serum Samples ◽  
Early Screening ◽  
Roc Curve Analysis

Abstract BACKGROUND Early diagnosis is very important to improve the survival rate of patients with gastric cancer, especially in asymptomatic participants. However, low sensitivity of common biomarkers has caused difficulties in early screening of gastric cancer. In this study, we explored whether MIC-1 can improve the detection rate of early gastric cancer.METHODS We screened 8,257 participants based on risk factors such as age, gender, and family history for physical examination including gastroscopy. Participant blood samples were taken for measure MIC-1, CA-199, CA72-4 and PG1/PG2 levels. The diagnostic performance of MIC-1 was assessed and compared with CA-199, CA72-4 and PG1/PG2, and its role in early gastric cancer diagnosis and the assessment of the risk of precancerous lesions have also been studied.RESULTS Based on endoscopic and histopathological findings, 55 participants had gastric cancer, 566 participants had low-grade neoplasia, 2605 participants had chronic gastritis. MIC-1 levels were significantly elevated in gastric cancer serum samples as compared to controls (p<0.001). The sensitivity of serum MIC-1 for gastric cancer diagnosis was much higher than that of CA-199 (49.1% vs. 20.0%) with similar specificities. Moreover, receiver operating characteristic (ROC) curve analysis also showed that serum MIC-1 had a better performance compared with CA-199, CA72-4 and PG1/PG2 in distinguishing early-stage gastric cancer (AUC: 72.9% vs. 69.5%, 67.5%, 44.0% respectively).CONCLUSIONS Serum MIC-1 is significantly elevated in most patients with early gastric cancer. MIC-1 can serve as a novel diagnostic marker of early gastric cancer and value the risk of gastric cancer.

Postoperative Evaluation of Pylorus-Preserving Procedures Compared with Conventional Distal Gastrectomy for Early Gastric Cancer

Surgery Today ◽  
2001 ◽  
Vol 31 (9) ◽  
pp. 774-779 ◽  
Author(s):  
Tsukasa Hotta ◽  
Katsutoshi Taniguchi ◽  
Yasuhito Kobayashi ◽  
Kiyofumi Johata ◽  
Masaki Sahara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Distal Gastrectomy ◽  
Postoperative Evaluation

Outcomes After Laparoscopic or Open Distal Gastrectomy for Early-Stage Gastric Cancer

2013 ◽  
Vol 257 (4) ◽  
pp. 640-646 ◽  
Author(s):  
Hideo Yasunaga ◽  
Hiromasa Horiguchi ◽  
Kazuaki Kuwabara ◽  
Shinya Matsuda ◽  
Kiyohide Fushimi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Distal Gastrectomy ◽  
Early Stage ◽  
Open Distal Gastrectomy
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