scholarly journals Gene Expression Profiles of Prostate Cancer Cell Lines, LNCaP, PC-3 and DU-145, Assessed by cDNA Microarray

2008 ◽  
Vol 58 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Keigo Okamura ◽  
Hidekazu Koike ◽  
Hiroshi Matsui ◽  
Kazuhiro Suzuki
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cdna Microarray ◽  
Prostate Cancer Cell ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines

Gene Expression Profiling of Prostate Cancer–Associated Genes Identifies Fibromodulin as Potential Novel Biomarker for Prostate Cancer

2016 ◽  
Vol 31 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Alfonso Bettin ◽  
Ismael Reyes ◽  
Niradiz Reyes
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Expression Profiles ◽  
Cancer Cell Lines ◽  
Clinical Samples ◽  
Prostate Cancer Cell Lines

Background The aim of this study was to evaluate the gene expression profiles of a set of prostate cancer–associated genes in prostate cancer cell lines, to determine their association with different cancer phenotypes and identify potential novel biomarkers for this disease. Methods Quantitative real-time PCR was used to determine the expression profiles of 21 prostate cancer–associated genes in the human prostate cancer cell lines PC-3 and LNCaP, using the nontumorigenic cell line PWR-1E as control cell line. Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3. A potential biomarker from this set of genes, the FMOD gene, encoding the small leucine-rich proteoglycan fibromodulin, was selected for further evaluation in clinical samples from patients diagnosed with benign or malignant prostatic disease. Results Several of the evaluated genes showed significantly altered expression in the prostate cancer cell lines, compared with nontumorigenic PWR-1E cells. Further evaluation of FMOD transcript in prostate clinical samples from patients diagnosed with benign or malignant prostatic disease identified a significant difference in the expression levels of this proteoglycan between benign and malignant tissue (p<0.05). Conclusions A number of gene transcripts were differentially expressed by the cell lines assayed. Among them, FMOD was further evaluated in clinical samples and was found to be differentially expressed between benign and prostate cancer tissue. Further validation of FMOD transcript in a larger population is required to ascertain its usefulness as biomarker for prostate cancer.

scholarly journals MicroRNAs and zinc metabolism-related gene expression in prostate cancer cell lines treated with zinc(II) ions

2012 ◽  
Vol 41 (6) ◽  
pp. 2237-2244 ◽  
Author(s):  
MARIAN HLAVNA ◽  
MARTINA RAUDENSKA ◽  
KRISTYNA HUDCOVA ◽  
JAROMIR GUMULEC ◽  
MARKETA SZTALMACHOVA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Zinc Metabolism ◽  
Related Gene ◽  
Prostate Cancer Cell Lines

Effect of Ducrosia flabellifolia and Savignya parviflora Extracts on Inhibition of Human Colon and Prostate Cancer Cell Lines

2021 ◽  
Vol 43 (3) ◽  
pp. 1518-1528
Author(s):  
Youssef Saeed Alghamdi ◽  
Osama Moseilhy Saleh ◽  
Nada Alqadri ◽  
Mutaib Mosaued Mashraqi ◽  
Omar Bahattab ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Lines ◽  
Cancer Cell ◽  
Bioactive Compounds ◽  
Plant Extracts ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines

The goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysis, induction of apoptosis and gene expression of Bcl-2 and Bax genes were studied. Obtained results indicated that, the plant extracts exhibit growth inhibition of used cancer cell lines and induced apoptosis as well as arresting of cell cycle. At the molecular level, changes in gene expression were detected via qPCR and confirmed by western blotting. The exhibited anticancer potentialities of plant extracts against utilized cancer cell lines are due to its containing bioactive compounds. Further detailed isolation, fractionation and characterization of bioactive compounds are needed.

scholarly journals Androgen Receptor Controls EGFR and ERBB2 Gene Expression at Different Levels in Prostate Cancer Cell Lines

2009 ◽  
Vol 69 (7) ◽  
pp. 2941-2949 ◽  
Author(s):  
Jean-Christophe Pignon ◽  
Benjamin Koopmansch ◽  
Gregory Nolens ◽  
Laurence Delacroix ◽  
David Waltregny ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Erbb2 Gene ◽  
Different Levels
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