scholarly journals Multiple Primary Lung Cancer with Large Cell Carcinomaand Adenocarcinoma. A Case Report and a Review of the Japanese Literature.

1998 ◽  
Vol 48 (2) ◽  
pp. 171-174
Author(s):  
Mitsuhiro Kamiyoshihara ◽  
Toshikazu Hirai ◽  
Osamu Kawashima ◽  
Susumu Ishikawa ◽  
Yasuo Morishita ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Primary Lung Cancer ◽  
Japanese Literature ◽  
Large Cell ◽  
Multiple Primary

scholarly journals Diagnosis and treatment of synchronous multiple primary lung cancer – a case report

2019 ◽  
Vol Volume 12 ◽  
pp. 4281-4285
Author(s):  
Yi Bao ◽  
Jiayuan Wu ◽  
Jun Zhang ◽  
Yawei Yu
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Primary Lung Cancer ◽  
Diagnosis And Treatment ◽  
Multiple Primary

scholarly journals Synchronous Multiple Primary Lung Cancer: A Case Report

2018 ◽  
Vol 8 (2) ◽  
pp. 162-164
Author(s):  
Alexei Charyshkin ◽  
Evgeniy Toneev ◽  
Alexander Martynov ◽  
Ruslan Lisyutin ◽  
Airat Zul’karnyaev
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Primary Lung Cancer ◽  
Multiple Primary

scholarly journals Multiple Primary Lung Cancer – a Case Report and Literature Review

2016 ◽  
Vol 29 (4) ◽  
pp. 287-290
Author(s):  
Zdeněk Chovanec ◽  
Ivan Čapov ◽  
Adam Peštál ◽  
Michal Benej ◽  
Martin Páral
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Literature Review ◽  
Primary Lung Cancer ◽  
Multiple Primary

scholarly journals Endobronchial brachytherapy combined with surgical procedure for synchronous multiple primary lung cancer: A case report

2021 ◽  
Vol 12 (8) ◽  
pp. 1252-1255
Author(s):  
Kazuki Omori ◽  
Yoshihito Nomoto ◽  
Tomoko Kawamura ◽  
Makiko Kubooka ◽  
Koji Kawaguchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Surgical Procedure ◽  
Primary Lung Cancer ◽  
Multiple Primary

scholarly journals Primary lung cancer with metastasis to the ipsilateral breast-a case report

2017 ◽  
Vol 6 (1) ◽  
pp. 334 ◽  
Author(s):  
Abdalla Saad Abdalla Al-Zawi ◽  
Andrzej Ratajczak ◽  
Philip Idaewor ◽  
Mohamed Elamass ◽  
Anita Lazarevska ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Primary Lung Cancer ◽  
Left Breast ◽  
Contralateral Breast ◽  
Ipsilateral Breast ◽  
Breast Lump ◽  
Breast Metastases

The metastasis of extra-mammary malignancy to breast is extremely rare; literature reports the incidence between 0.4-1.3%. Primary sites include the contralateral breast, leukaemia, lymphoma, malignant melanoma, sarcoma, lung, prostate, ovary, colon and the stomach. Here we present a rare case in which lung cancer was found to metastasise to the breast. Initially the patient presented with chest symptoms and a left breast lump was detected clinically. The radiological and histological investigations confirmed the diagnosis of primary lung cancer with breast metastases. Prognosis of such cases is generally poor.

scholarly journals Molecular Identification and Genetic Characterization of Early-Stage Multiple Primary Lung Cancer by Large-Panel Next-Generation Sequencing Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Guotian Pei ◽  
Mingwei Li ◽  
Xianjun Min ◽  
Qiang Liu ◽  
Dasheng Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Early Stage ◽  
Primary Lung Cancer ◽  
Advanced Stage ◽  
Next Generation ◽  
Molecular Method ◽  
Multiple Primary ◽  
Large Panel ◽  
Generation Sequencing

ObjectiveThe incidence of early stage multiple primary lung cancer (MPLC) has been increasing in recent years, while the ideal strategy for its diagnosis and treatment remains controversial. The present study conducted genomic analysis to identify a new molecular classification method for accurately predicting the diagnosis and therapy for patients with early stage MPLC.MethodsA total of 240 tissue samples from 203 patients with multiple-non-small-cell lung cancers (NSCLCs) (n = 30), early stage single-NSCLC (Group A, n = 94), and advanced-stage NSCLC (Group B, n = 79) were subjected to targeted multigene panel sequencing.ResultsThirty patients for whom next-generation sequencing was performed on >1 tumor were identified, yielding 45 tumor pairs. The frequencies of EGFR, TP53, RBM10, ERBB2, and CDKN2A mutations exhibited significant differences between early and advanced-stage NSCLCs. The prevalence of the EGFR L858R mutation in early stage NSCLC was remarkably higher than that in advanced-stage NSCLC (P = 0.047). The molecular method classified tumor pairs into 26 definite MPLC tumors and four intrapulmonary metastasis (IM) tumors. A high rate of discordance in driver genetic alterations was found in the different tumor lesions of MPLC patients. The prospective Martini histologic prediction of MPLC was discordant with the molecular method for three patients (16.7%), particularly in the prediction of IM (91.7% discordant).ConclusionsComprehensive molecular evaluation allows the unambiguous delineation of clonal relationships among tumors. In comparison, the Martini and Melamed criteria have notable limitations in the recognition of IM. Our results support the adoption of a large panel to supplement histology for strongly discriminating NSCLC clonal relationships in clinical practice.

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