scholarly journals Diels-Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

2013 ◽  
Vol 54 (11) ◽  
pp. 1989-1995 ◽  
Author(s):  
R. Rossin ◽  
T. Lappchen ◽  
S. M. van den Bosch ◽  
R. Laforest ◽  
M. S. Robillard
Keyword(s):  
Radiation Dose ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction

Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction

2020 ◽  
Vol 31 (10) ◽  
pp. 2456-2464
Author(s):  
Byungseop Yang ◽  
Kiyoon Kwon ◽  
Subhashis Jana ◽  
Seoungkyun Kim ◽  
Savanna Avila-Crump ◽  
...  
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Temporal Control ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Electron Demand

In-depth evaluation of the cycloaddition–retro-Diels–Alder reaction for in vivo targeting with [111In]-DTPA-RGD conjugates

2009 ◽  
Vol 36 (7) ◽  
pp. 749-757 ◽  
Author(s):  
Peter Laverman ◽  
Silvie A. Meeuwissen ◽  
Sander S. van Berkel ◽  
Wim J.G. Oyen ◽  
Floris L. van Delft ◽  
...  
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction

scholarly journals Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3567 ◽  
Author(s):  
Mushtaq ◽  
Yun ◽  
Jeon
Keyword(s):  
Cycloaddition Reaction ◽  
Reaction Rates ◽  
Alder Reaction ◽  
Diels Alder ◽  
Pharmacokinetic Studies ◽  
Preclinical Research ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Specific Reactions

In recent years, several catalyst-free site-specific reactions have been investigated for the efficient conjugation of biomolecules, nanomaterials, and living cells. Representative functional group pairs for these reactions include the following: (1) azide and cyclooctyne for strain-promoted cycloaddition reaction, (2) tetrazine and trans-alkene for inverse-electron-demand-Diels–Alder reaction, and (3) electrophilic heterocycles and cysteine for rapid condensation/addition reaction. Due to their excellent specificities and high reaction rates, these conjugation methods have been utilized for the labeling of radioisotopes (e.g., radiohalogens, radiometals) to various target molecules. The radiolabeled products prepared by these methods have been applied to preclinical research, such as in vivo molecular imaging, pharmacokinetic studies, and radiation therapy of cancer cells. In this review, we explain the basics of these chemical reactions and introduce their recent applications in the field of radiopharmacy and chemical biology. In addition, we discuss the significance, current challenges, and prospects of using bioorthogonal conjugation reactions.

Two novel Diels-Alder adducts from Hippocratea celastroides roots and their insecticidal activity

2000 ◽  
Vol 78 (2) ◽  
pp. 248-254 ◽  
Author(s):  
M Jiménez-Estrada ◽  
R Reyes-Chilpa ◽  
S Hernández-Ortega ◽  
E Cristobal-Telésforo ◽  
L Torres-Colín ◽  
...  
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
X Ray Diffraction ◽  
Stored Grain ◽  
X Ray ◽  
Diels Alder Reaction ◽  
Antifeeding Activity ◽  
Hippocratea Celastroides ◽  
Stored Grain Insects

Two novel compounds, celastroidine A (1) and B (2), were isolated from the roots of Hippocratea celastroides K. Their structures were elucidated by spectroscopical and X-ray diffraction studies. Celastroidine A (1) (C50H74O5) was identified as a Diels-Alder adduct of a triterpene plus a diterpene and celastroidine B (2) as a beyerane, a type of dimer of two diterpene (C40H60O4). Both compounds could be formed in vivo by a Diels-Alder reaction. Celastroidine A showed some antifeeding activity against the stored grain insect Sitophyllus zeamays.Key words: Hippocratea celastroides, Hippocrataceae, roots, Diels-Alder adducts, diterpenoids, triterpenoids, x-ray diffraction, insect antifeedants, stored grain insects, Sitophyllus zeamays, insecticidal plants, Diels-Alderase.

The Diels-Alder Reaction of 2-Ethenyl-1,4-Benzodioxin: A New and Simple Synthesis of Bisaryl Ethers

Synlett ◽  
1989 ◽  
Vol 1989 (01) ◽  
pp. 30-32
Author(s):  
Thomas V. Lee ◽  
Alistair J. Leigh ◽  
Christopher B. Chapleo
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Simple Synthesis ◽  
Diels Alder Reaction

The intermolecular anthracene-transfer in a regiospecific antipodal C60 difunctionalization

2020 ◽  
Author(s):  
Radu Talmazan ◽  
Klaus R. Liedl ◽  
Bernhard Kräutler ◽  
Maren Podewitz
Keyword(s):  
Noncovalent Interactions ◽  
Interaction Model ◽  
Alder Reaction ◽  
Diels Alder ◽  
Stacking Interactions ◽  
Pi Stacking ◽  
Diels Alder Reaction ◽  
Double Decker ◽  
Anthracene Molecule ◽  
New Strategies

We analyze the mechanism of the topochemically controlled difunctionalization of C60 and anthracene, where an anthracene molecule is transferred from one C60 monoadduct to another one under exclusive formation of equal amounts of C60 and the difficult to make antipodal C60 bisadduct. Our herein disclosed dispersion corrected DFT studies show the anthracene transfer to take place in a synchronous retro Diels-Alder/Diels-Alder reaction: an anthracene molecule dissociates from one fullerene under formation of an intermediate, while already undergoing stabilizing interactions with both neighboring fullerenes, facilitating the reaction kinetically. In the intermediate, a planar anthracene molecule is sandwiched between two neighboring fullerenes and forms equally strong "double-decker" type pi-pi stacking interactions with both of these fullerenes. Analysis with the distorsion interaction model shows that the anthracene unit of the intermediate is almost planar with minimal distorsions. This analysis sheds light on the existence of noncovalent interactions engaging both faces of a planar polyunsaturated ring and two convex fullerene surfaces in an unprecedented 'inverted sandwich' structure. Hence, it sheds light on new strategies to design functional fullerene based materials.<br>

Natural Products Biosynthesis Involving a Putative Diels-Alder Reaction

2016 ◽  
Vol 20 (22) ◽  
pp. 2421-2442 ◽  
Author(s):  
Kévin Cottet ◽  
Maria Kolympadi ◽  
Dean Markovic ◽  
Marie-Christine Lallemand
Keyword(s):  
Natural Products ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction

Aza-Diels-Alder Reaction Between 1,2-Diaza-1,3-dienes and β-Aryl-α,β-unsaturated Carbonyl Compounds. Easy One-pot Entry to 2’-Oxo-imidazo[1’,5’- f]tetrahydropyridazine

2014 ◽  
Vol 10 (6) ◽  
pp. 951-960
Author(s):  
Orazio Attanasi ◽  
Luca Bianchi ◽  
Maurizio D’Auria ◽  
Gianfranco Favi ◽  
Fabio Mantellini ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Alder Reaction ◽  
Diels Alder ◽  
One Pot ◽  
Diels Alder Reaction
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