scholarly journals An Effective Quantitative Method (Node Count Method) for Evaluation of Endocrine-Disrupting Chemicals Based on Secondary Sexual Characteristics of Medaka (Oryzias latipes)

2004 ◽  
Vol 27 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Bin-Le LIN ◽  
Satoshi HAGINO ◽  
Michio KAGOSHIMA ◽  
Shouji ASHIDA ◽  
Takashi IWAMATSU ◽  
...  
Keyword(s):  
Quantitative Method ◽  
Endocrine Disrupting Chemicals ◽  
Oryzias Latipes ◽  
Secondary Sexual Characteristics ◽  
Count Method ◽  
Endocrine Disrupting ◽  
Sexual Characteristics ◽  
Node Count ◽  
Secondary Sexual

scholarly journals Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence

2020 ◽  
Vol 21 (6) ◽  
pp. 2078 ◽  
Author(s):  
Laura Lucaccioni ◽  
Viola Trevisani ◽  
Lucia Marrozzini ◽  
Natascia Bertoncelli ◽  
Barbara Predieri ◽  
...  
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Current Evidence ◽  
Secondary Sexual Characteristics ◽  
Endocrine Disrupting ◽  
Sexual Characteristics ◽  
Single Chemical ◽  
Windows Of Susceptibility ◽  
Physical Changes ◽  
Temporal Windows

Puberty is the process of physical changes between childhood and adulthood during which adolescents reach sexual maturity and become capable of reproduction. It is considered one of the main temporal windows of susceptibility for the influence of the endocrine-disrupting chemicals (EDCs). EDCs may act as single chemical agents or as chemical mixtures; they can be pubertal influencers, accelerating and anticipating the processing of maturation of secondary sexual characteristics. Moreover, recent studies have started to point out how exposure to EDCs during puberty may predispose to breast cancer later in life. In fact, the estrogen-mimicking endocrine disruptors (EEDs) may influence breast tissue development during puberty in two main ways: the first is the action on the proliferation of the breast stromal cells, the second concerns epigenetic mechanisms. The aim of this mini-review was to better highlight what is new and what is not completely known regarding the role of EDCs during puberty.

Reproductive failure of the red shiner (Cyprinella lutrensis) after exposure to an exogenous estrogen

2010 ◽  
Vol 67 (11) ◽  
pp. 1730-1743 ◽  
Author(s):  
Michelle M. McGree ◽  
Dana L. Winkelman ◽  
Nicole  K.M.  Vieira ◽  
Alan  M.  Vajda
Keyword(s):  
Reproductive Success ◽  
Great Plains ◽  
Endocrine Disrupting Chemicals ◽  
Water Control ◽  
Secondary Sexual Characteristics ◽  
Cyprinella Lutrensis ◽  
The Us ◽  
Sexual Characteristics ◽  
Solvent Control ◽  
17Β Estradiol

Endocrine disrupting chemicals (EDCs) have been detected in surface waters worldwide and can lead to developmental and reproductive disruption in exposed fishes. In the US Great Plains, EDCs are impacting streams and rivers and may be causing adverse reproductive effects. To examine how estrogenic EDCs might affect reproductive success of plains fishes, we experimentally exposed male red shiners ( Cyprinella lutrensis ) to exogenous 17β-estradiol. We characterized the effects of estradiol on male gonadal histology and secondary sexual characteristics, determined whether exposure reduced reproductive success, and examined the effects of depuration. Adults were exposed to a mean concentration of 70 ng·L−1 estradiol, a solvent control, or a water control for at least 83 days. Male exposure to estradiol resulted in elevated plasma vitellogenin concentrations, changes in spermatogenesis, reduced mating coloration and tubercles, altered mating behaviors, and reduced reproductive success with no viable progeny produced. Reproductive endpoints improved upon depuration (28 days). Exposure to estradiol had significant adverse effects on red shiners, indicating that wild populations may face developmental and reproductive difficulties if they are chronically exposed to estradiol.

Comparative urogenital morphology and external sex determination in muskellunge, Esox masquinongy Mitchill

1989 ◽  
Vol 67 (4) ◽  
pp. 1053-1060 ◽  
Author(s):  
Bernard Lebeau ◽  
Gérard Pageau
Keyword(s):  
Ventral Surface ◽  
Northern Pike ◽  
Structural Basis ◽  
Simple Method ◽  
Esox Masquinongy ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Spawning Behaviour ◽  
Accurate Indicator ◽  
Secondary Sexual

Primary and secondary sexual characteristics in northern pike, Esox lucius Linneaus, and muskellunge, Esox masquinongy Mitchill, differ markedly. Differences in the internal urogenital anatomy include the structure of the genital ducts and the angle they form with the ventral surface. Externally, the genital and urinary ducts open directly to the environment in northern pike, whereas in muskellunge they open into a muscular papilla and then through a urogenital pore. Differences in sexual dimorphism between the two closely related esocids constitute a structural basis to explain the known differences in spawning behaviour and reproductive success. Differences in secondary sexual characteristics explain why the methods developed by Demchenko or Casselman to externally sex pike are inapplicable to muskellunge. To develop and test two external sexing techniques for muskellunge, specimens were collected from two regions in Canada from 1980 to 1987. Examination of reproductive products obtained from stripping provided an accurate indicator of sex and sexual maturity, but demonstrated serious limitations. A simple method to sex muskellunge by examination of the external urogenital morphology is described for juveniles and adults. Dissection of fish revealed that with the urogenital examination technique we sexed juveniles with a success rate of 92–98%, and adults with 100% accuracy.

The effects of phthalate and nonylphenol exposure on body size and secondary sexual characteristics during puberty

2015 ◽  
Vol 218 (7) ◽  
pp. 603-615 ◽  
Author(s):  
Jia-Woei Hou ◽  
Ching-Ling Lin ◽  
Yen-An Tsai ◽  
Chia-Huang Chang ◽  
Kai-Wei Liao ◽  
...  
Keyword(s):  
Body Size ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Secondary Sexual

scholarly journals Somatotypical features of the age dynamics of secondary sexual characteristics and functional parameters in city schoolchildren

2021 ◽  
pp. 113-118
Author(s):  
V. A. Melnik
Keyword(s):  
Blood Pressure ◽  
Body Type ◽  
Age Dynamics ◽  
Functional Parameters ◽  
Secondary Sexual Characteristics ◽  
Age Related ◽  
Sexual Characteristics ◽  
Age Range ◽  
Age Related Changes ◽  
Secondary Sexual

Objective: to assess the constitutional features of the age dynamics of secondary sexual characteristics and functional parameters of city schoolchildren in the age range of 7–17 years.Materials and methods. The objects of the study were schoolchildren aged 7–17. The stages of the expression of secondary sexual characteristics were determined visually according to the scheme by J.M. Tanner. The functional parameters of the examined schoolchildren were assessed using the methods of dynamometry, spirometry; blood pressure and heart rates, as well as the time of simple sensorimotor reactions were measured.Results. As a result of the performed studies, it has been found that representatives of the hypersomnic types are ahead of other types to reveal the first stages of secondary sexual characteristics. Schoolchildren with the leptosomic morphotypes due to higher rates of their development have reached the definitive stages by the same age as those with the hypersomnic variants. The intensity of age-related changes in functional parameters (strength qualities, circulatory and respiratory systems, nervous system) in the studied objects depends on their body type.Conclusion. The stage and rate of puberty, as well as the development of functional parameters in city schoolchildren depends on their somatotype.

scholarly journals Hypertension, hypokalemia, and left adrenal tumor mimicking primary aldosteronism in a patient with 17α-hydroxylase deficiency

2019 ◽  
Vol 7 (1) ◽  
pp. 6
Author(s):  
Shu-Heng Huang ◽  
Daw-Yang Hwang ◽  
Shang-Jyh Hwang
Keyword(s):  
Primary Aldosteronism ◽  
Adrenal Tumor ◽  
Laboratory Data ◽  
Adrenal Incidentaloma ◽  
Plasma Renin ◽  
Secondary Hypertension ◽  
Hydroxylase Deficiency ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Secondary Sexual

17α-hydroxylase deficiency (17OHD) is a rare disorder of secondary hypertension caused by congenital adrenal hyperplasia. In addition, co-occurrence of an adrenal tumor with 17OHD is extremely rare and easily misdiagnosed. A 33-year-old female with sicca syndrome, persistent hypertension, hypokalemia, and a left adrenal tumor was referred for confirmation of primary aldosteronism. However, the absence of secondary sexual characteristics, persistent growth beyond puberty, and laboratory data of low plasma renin activity, high aldosterone, low cortisol, low sex hormones, elevated adrenocorticotropic hormone, elevated luteinizing hormone, elevated follicle-stimulating hormone, and most importantly, decreased 17-hydroxypregnenolone, supported a diagnosis of 17OHD. We sequenced the CYP17A1 gene of the patient and her parents, which demonstrated genetic defects (D487-S,488-F489 deletion and Y329K418X). 17OHD was diagnosed. The left adrenal tumor was assessed, and a non-functional adrenal incidentaloma was confirmed; NP-59 adrenal cortical scintigraphy and adrenal venous sampling showed no functional activity and non-lateralization. Hormone replacements with estrogen, spironolactone, and prednisolone were given. The patient became more feminized and confident, and her hypertension was controlled. Early diagnosis and treatment of 17OHD not only can prevent delay development of secondary sexual characteristics but also help the patient maintain mental health and improve their quality of life. In addition, the concomitant presence of a left adrenal tumor makes misdiagnosis of a functional adenoma more likely, possibly causing unnecessary surgery and delay inappropriate treatment.

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