scholarly journals The effect of a multiple drug therapy with Inchinkoto, a herbal medicine on bile acids and bilirubin in two patients with prolonged severe mixed type of drug induced liver injury

Kanzo ◽  
2012 ◽  
Vol 53 (5) ◽  
pp. 291-297 ◽  
Author(s):  
Ryosuke Sakemi ◽  
Seiya Kakiuchi ◽  
Yosuke Morimitsu ◽  
Yasuhiko Kubo ◽  
Satoru Matsugaki ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Herbal Medicine ◽  
Liver Injury ◽  
Bile Acids ◽  
Mixed Type ◽  
Multiple Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Multiple Drug Therapy

scholarly journals Bile acids in drug induced liver injury: Key players and surrogate markers

2016 ◽  
Vol 40 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Heiko S. Schadt ◽  
Armin Wolf ◽  
Francois Pognan ◽  
Salah-Dine Chibout ◽  
Michael Merz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Acids ◽  
Surrogate Markers ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Key Players

scholarly journals Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 282
Author(s):  
Cristina Gómez ◽  
Simon Stücheli ◽  
Denise V. Kratschmar ◽  
Jamal Bouitbir ◽  
Alex Odermatt
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Bile Acids ◽  
Liver Tissue ◽  
Bioactive Molecules ◽  
Rodent Species ◽  
Drug Induced ◽  
Tissue Samples ◽  
Drug Induced Liver Injury ◽  
Bile Acid Profiles

Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with several diseases and drug-induced liver injury. Individual bile acids may serve as disease and drug toxicity biomarkers, with a great demand for improved bile acid quantification methods. We developed, optimized, and validated an LC-MS/MS method for quantification of 36 bile acids in serum, plasma, and liver tissue samples. The simultaneous quantification of important free and taurine- and glycine-conjugated bile acids of human and rodent species has been achieved using a simple workflow. The method was applied to a mouse model of statin-induced myotoxicity to assess a possible role of bile acids. Treatment of mice for three weeks with 5, 10, and 25 mg/kg/d simvastatin, causing adverse skeletal muscle effects, did not alter plasma and liver tissue bile acid profiles, indicating that bile acids are not involved in statin-induced myotoxicity. In conclusion, the established LC-MS/MS method enables uncomplicated sample preparation and quantification of key bile acids in serum, plasma, and liver tissue of human and rodent species to facilitate future studies of disease mechanisms and drug-induced liver injury.

scholarly journals A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine

2015 ◽  
Vol 65 (6) ◽  
pp. 375
Author(s):  
Gi Jung Jeon ◽  
Jongha Park ◽  
Min Sung Kim ◽  
Jong Won Yu ◽  
Jae Hyun Park ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Liver Injury ◽  
Lead Poisoning ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Targeted Metabolomics Analysis of Bile Acids in Patients with Idiosyncratic Drug-Induced Liver Injury

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 852
Author(s):  
Zhongyang Xie ◽  
Lingjian Zhang ◽  
Ermei Chen ◽  
Juan Lu ◽  
Lanlan Xiao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Bile Acids ◽  
Characteristic Curve ◽  
High Rate ◽  
Targeted Metabolomics ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Severe Group ◽  
Independent Risk Factors

Drug-induced liver injury (DILI) is rare but clinically important due to a high rate of mortality. However, specific biomarkers for diagnosing and predicting the severity and prognosis of DILI are lacking. Here, we used targeted metabolomics to identify and quantify specific types of bile acids that can predict the severity of DILI. A total of 161 DILI patients were enrolled in this prospective cohort study, as well as 31 health controls. A targeted metabolomics method was used to identify 24 types of bile acids. DILI patients were divided into mild, moderate, and severe groups according to disease severity. A multivariate analysis was performed to identify characteristic bile acids. Then the patients were divided into severe and non-severe groups, and logistic regression was used to identify bile acids that could predict DILI severity. Among the enrolled DILI patients, 32 were in the mild group, 90 were in the moderate group, and 39 were in the severe group. Orthogonal partial least squares-discriminant analysis (OPLS-DA) modeling clearly discriminated among the different groups. Among the four groups, glycochenodeoxycholate (GCDCA), taurochenodeoxycholate (TCDCA), deoxycholic acid (DCA), Nor Cholic acid (NorCA), glycocholic acid (GCA), and taurocholic acid (TCA) showed significant differences in concentration between at least two groups. NorCA, GCDCA, and TCDCA were all independent risk factors that differentiated severe DILI patients from the other groups. The area under the receiver operating characteristic curve (AUROC) of GCDCA, TCDCA, and NorCA was 0.856, 0.792, and 0.753, respectively. Together, these three bile acids had an AUROC of 0.895 for predicting severe DILI patients. DILI patients with different disease severities have specific bile acid metabolomics. NorCA, GCDTA, and TCDCA were independent risk factors for differentiating severe DILI patients from less-severe patients and have the potential to predict DILI severity.

Application of International Consensus Meeting Criteria for Classifying Drug-Induced Liver Disorders

1995 ◽  
Vol 29 (9) ◽  
pp. 875-878 ◽  
Author(s):  
Jean-Francois Bussières ◽  
Magdi Habra
Keyword(s):  
Liver Injury ◽  
Mixed Type ◽  
Final Diagnosis ◽  
Liver Disorder ◽  
Consensus Meeting ◽  
Drug Induced ◽  
International Consensus ◽  
Liver Disorders ◽  
Drug Induced Liver Injury ◽  
Screening And Diagnosis

Objective: To report a patient with 2 consecutive reversible drug-induced liver disorders and the application of International Consensus Meeting Criteria for the screening and diagnosis of drug-induced liver disorders. Case Summary: An 88-year-old man in a chronic care institution developed abdominal discomfort and jaundice after finishing a 10-day course of trimethoprim/sulfamethoxazole therapy for a urinary tract infection (UTI). The jaundice and the symptoms resolved spontaneously and the final diagnosis was symptomatic drug-induced liver injury, mixed type. After 1 month, the same patient received a course of cefadroxil therapy for another UTI. He developed an asymptomatic drug-induced liver injury, mixed type. Six months later, the patient received oral penicillin therapy and then ciprofloxacin, with no change in his liver function test results. Discussion: To our knowledge, there are only a few other reports in the literature of a drug-induced liver injury with Cefadroxil therapy; more cases are reported with trimethoprim/sulfamethoxazole than with cefadroxil. The criteria of an International Consensus Meeting were helpful to evaluate both incidences of liver injury in this patient with the aim of establishing the diagnosis and causality assessment. Additionally, the criteria were used to show that the patient had 2 separate liver injuries. Conclusions: Screening and diagnosis of drug-induced liver disorders depend on careful history taking and 5 specific biochemical liver tests. The evolution of the liver disorder induced by Cefadroxil therapy probably was interrupted because of its early detection. Appropriate screening was done with the subsequent administration of new potentially hepatotoxic drugs.

scholarly journals A Case Report on Drug-induced Liver Injury Induced by Antilipidemic Agents

2021 ◽  
Vol 42 (5) ◽  
pp. 777-783
Author(s):  
Seo-hye Oh ◽  
Gi-hyeon Gwon ◽  
Eun-su Park ◽  
Won-young Kim ◽  
Dong-young Kim
Keyword(s):  
Case Report ◽  
Herbal Medicine ◽  
Liver Injury ◽  
Liver Function ◽  
Total Cholesterol ◽  
Effective Treatment ◽  
Treatment Effect ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Objective: This case report describes a patient who suffered a drug-induced liver injury and was treated with Saengganggeonbi-tang.Methods: A patient was treated with Korean herbal medicine, and the treatment effect was evaluated using liver function tests (LFT) to determine total cholesterol and triglyceride levels.Results: The patient’s LFT levels were normal on 27 July 2021 but became abnormal by 12 August 2021 after taking Western drugs. After 15 days of treatment with Saengganggeonbi-tang, the LFT levels had improved.Conclusion: This study shows that Saenggangeonbi-tang may be an effective treatment for drug-induced liver injury.

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