scholarly journals Fatty liver in Japanese patients with type 2 diabetes: clinical features and risk factors

Kanzo ◽  
2006 ◽  
Vol 47 (1) ◽  
pp. 38-39
Author(s):  
N Toshikuni ◽  
K Nakashima ◽  
A Omoto ◽  
M Mitsunaga
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Fatty Liver ◽  
Clinical Features ◽  
Japanese Patients

scholarly journals Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver

2017 ◽  
Vol 9 (3) ◽  
pp. 529-535 ◽  
Author(s):  
Yasuhiko Furukawa ◽  
Yoshifumi Tamura ◽  
Kageumi Takeno ◽  
Takashi Funayama ◽  
Hideyoshi Kaga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Japanese Patients ◽  
Peripheral Insulin Sensitivity

scholarly journals Combined Influence of Insulin Resistance, Overweight/Obesity, and Fatty Liver as Risk Factors for Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (4) ◽  
pp. 717-722 ◽  
Author(s):  
K.-C. Sung ◽  
W.-S. Jeong ◽  
S. H. Wild ◽  
C. D. Byrne
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Liver

Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with Type 2 diabetes

2013 ◽  
Vol 125 (6) ◽  
pp. 301-310 ◽  
Author(s):  
Giovanni Targher ◽  
Alessandro Mantovani ◽  
Isabella Pichiri ◽  
Riccardo Rigolon ◽  
Marco Dauriz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hospitalized Patients ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

NAFLD (non-alcoholic fatty liver disease) and AF (atrial fibrillation) are two pathological conditions that are highly prevalent in developed countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected participants on the basis of ECGs and medical history by experienced cardiologists. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases. Of the 702 hospitalized patients included in the study, 514 (73.2%) of them had NAFLD and 85 (12.1%) had persistent or permanent AF. NAFLD was associated with an increased risk of prevalent AF {OR (odds ratio), 3.04 [95% CI (confidence interval), 1.54–6.02]; P<0.001}. Adjustments for age, sex, systolic BP (blood pressure), HbA1c, (glycated haemoglobin), estimated GFR (glomerular filtration rate), total cholesterol, electrocardiographic LVH (left ventricular hypertrophy), COPD (chronic obstructive pulmonary disease), and prior history of HF (heart failure), VHD (valvular heart disease) or hyperthyroidism did not attenuate the association between NAFLD and AF [adjusted OR, 5.88 (95% CI, 2.72–12.7); P<0.001]. In conclusion, our results show that ultrasound-diagnosed NAFLD is strongly associated with an increased prevalence of persistent or permanent AF in patients with Type 2 diabetes, independently of several clinical risk factors for AF. The potential impact of NAFLD on AF deserves particular attention, especially with respect to the implications for screening and surveillance strategies in the growing number of patients with NAFLD.

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