scholarly journals Structural analysis on the carbohydrate chains of human transferrin from sera of patients with hepatocellular carcinoma and liver cirrhosis. Comparison with those of human alpha-fetoprotein.

Kanzo ◽  
1994 ◽  
Vol 35 (8) ◽  
pp. 587-595 ◽  
Author(s):  
Tsuyoshi YOKOTA
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Structural Analysis ◽  
Alpha Fetoprotein ◽  
Human Transferrin ◽  
Carbohydrate Chains

scholarly journals The progressive elevation of alpha fetoprotein for the diagnosis of hepatocellular carcinoma in patients with liver cirrhosis

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Oscar Arrieta ◽  
Bernardo Cacho ◽  
Daniela Morales-Espinosa ◽  
Ana Ruelas-Villavicencio ◽  
Diana Flores-Estrada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Alpha Fetoprotein

scholarly journals Hepatocellular carcinoma in Brazil: report of a national survey (Florianópolis, SC, 1995)

1997 ◽  
Vol 39 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Carlos S. GONÇALVES ◽  
Fausto E. L. PEREIRA ◽  
Luis C.C. Gayotto
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Rio De Janeiro ◽  
Minas Gerais ◽  
Sao Paulo ◽  
Alpha Fetoprotein ◽  
Hcv Infection ◽  
Etiological Factors ◽  
Medical Centers ◽  
Espirito Santo

In order to investigate epidemiological aspects of hepatocellular carcinoma (HCC) in Brazil, basic informations about cases diagnosed from January 1992 to December 1994 were requested to several medical centers of different Brazilian States. A simple questionnaire included age, sex, alcohol abuse (over 80g/day), associated liver cirrhosis, persistent HBV infection (HBsAg), HCV infection (anti-HCV) and serum levels of alpha fetoprotein. 287 cases, over 16 years old, from 19 medical centers of 8 States (Pará, Bahia, Minas Gerais, Espirito Santo, Rio de Janeiro, São Paulo, Paraná and Rio Grande do Sul) were analysed. The results showed: (a) Mean age was 56.3 ± 14.4 for men and 54.7 ± 16.8 yr for women and the male/female ratio was 3.4:1. (b) 69.6% were caucasians, 21.8% mullatoes, 4.8% orientals and 3.7% blacks. (c) HBsAg (+) in 77/236 cases (41.6%) without differences between males and females. (d) Anti-HCV (+) in 52/193 cases (26.9%). (e) 7/180 cases were positive both for HBsAg and anti-HCV (3.8%). (f) There was chronic alcoholism in 88/235 cases (37%). (g) HCC was found in cirrhotic livers in 71.2% of 202 cases in which the presence or absence of cirrhosis was reported. (h) Alpha-fetoprotein above 20 ng/ml was found in 124/172 cases (72%) and above 500 ng/ml only in 40 cases (23.2%). These results showed that the HCC in Brazil has an intermediate epidemiological pattern as compared to those from areas of low and high incidence of the tumor. In spite of the high frequency of the association of HCC with the HBV and/or HCV infections, 42% of 180 cases were negative both for HBsAg and anti-HCV, indicating the possible role of other etiological factors. The comparison of data from different States showed some regional differences: higher frequency of associated HBsAg in Pará, Bahia, Minas Gerais and Espírito Santo, higher frequency of associated HCV infection in Rio de Janeiro, São Paulo and States of the Southern region and low frequency of associated liver cirrhosis in Salvador and Rio de Janeiro (55.5 and 50% respectively). Further investigation will be necessary to study the presence of other possible etiological factors as aflatoxins, suggested by the favourable climatic conditions for food contamination by fungi in the majority Brazilian regions

scholarly journals Combined Analysis of Serum Alpha-Fetoprotein and MAGE-A3-Specific Cytotoxic T Lymphocytes in Peripheral Blood for Diagnosis of Hepatocellular Carcinoma

2013 ◽  
Vol 35 ◽  
pp. 915-923 ◽  
Author(s):  
Zhuqingqing Cui ◽  
Xin Yu ◽  
Limin Guo ◽  
Yuhua Wei ◽  
Shengmin Zheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Peripheral Blood ◽  
Alpha Fetoprotein ◽  
Detection Technology ◽  
Serum Alpha Fetoprotein ◽  
Malignant Lesions ◽  
Combined Detection

We investigated the feasibility of the combined detection of HLA-A2/MAGE-A3 epitope-specific cytotoxic T lymphocytes (CTLs) and serum alpha-fetoprotein (AFP) for specific diagnosis of hepatocellular carcinoma (HCC). We detected the frequency of MAGE-A3 epitopes (p112–120, KVAELVHFL) in spontaneous CTLs in the peripheral blood of HCC patients, liver cirrhosis patients, and healthy subjects with HLA-A2/polypeptide complex (pentamer) detection technology. Eighty-five HCC cases, 38 liver cirrhosis cases, and 50 healthy cases who were HLA-A2-positive were selected from 175 HCC patients, 80 patients with liver cirrhosis, and 105 healthy volunteers, respectively. The frequency of HLA-A2-specific MAGE-A3+CTLs in the HCC group was significantly higher than that in the other groups. Combined detection of MAGE-A3+CTL frequency and serum AFP value had a higher specificity than either of the two indicators alone. The pentamer technique is helpful in distinguishing benign lesions and malignant lesions in the liver. Combined with serum AFP, it can improve the diagnosis performance for HCC, especially for AFP-negative cancer.

scholarly journals Hepatocellular carcinoma in patients with chronic hepatitis C: Experience gained at Clinical Center of Vojvodina

2014 ◽  
Vol 67 (suppl. 2) ◽  
pp. 31-38
Author(s):  
Maja Ruzic ◽  
Milotka Fabri ◽  
Tomislav Preveden ◽  
Sanja Stojanovic ◽  
Zoran Milosevic ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Alpha Fetoprotein ◽  
Focal Lesion ◽  
Hepatitis C Virus Infection

Introduction. The incidence of chronic hepatitis C and its consequences, liver cirrhosis and hepatocellular carcinoma is growing rapidly. The aim of this study was to evaluate clinical characteristics of patients with hepatocellular carcinoma and chronic hepatitis C treated at the Clinical Centre of Vojvodina and therapy options. Material and Methods. This retrospective study included 51 patients (52.9% male and 47.1% female) with chronic hepatitis C and hepatocellular carcinoma treated between 2000 and 2014. The average age of patients was 61.6 years (SD=10.8) and the average duration of hepatitis C virus infection was 30.2 years (SD=11.7). All patients had liver cirrhosis and 43.1% had previously been treated with pegylated interferon and ribavirin. According to the Barcelona Clinic Liver Cancer criteria, stadium A, B, C and D were found in 15.7%, 52.3%, 19.6% and 11.8% of the patients, respectively. The average value of alpha fetoprotein at the moment of making diagnosis of hepatocellular carcinoma was 397.56 ng/ml and the level of alpha fetoprotein was below 20mg/ml in 26% of patients. Tumor resection, radiofrequency ablation, chemoembolization, systemic chemotherapy and liver transplantation were performed in 13.7%, 3.9%, 1.9%, 1.9% and 5.9% of patients, respectively. Average survival time after the diagnosis of hepatocellular carcinoma among patients included in the study was 1.39 (SD=1.61) years. Conclusion. Ultrasound examinations of the patients with liver cirrhosis caused by hepatitis C virus infection are obligatory every 3 months. Etiology of every focal lesion in the liver must be clarified, which could increase the possibility of administration of available therapeutic methods.

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