scholarly journals A resected case of well-differentiated hepatocellular carcinoma, 4.0*5.5mm in diameter with definite tumor staining on hepatic angiography.

Kanzo ◽  
1990 ◽  
Vol 31 (7) ◽  
pp. 784-789
Author(s):  
Yuuichi TANABE ◽  
Sachiko SHINOMIYA ◽  
Kouhei TOMINAGA ◽  
Kaichiro HIROSHIGE ◽  
Nobuhiro KOYANAGI ◽  
...  
2021 ◽  
pp. 344-351
Author(s):  
Hiroki Kanno ◽  
Toshihiro Sato ◽  
Ryuta Midorikawa ◽  
Satoki Kojima ◽  
Shogo Fukutomi ◽  
...  

Hepatic epithelioid hemangioendothelioma (EHE) is a rare malignant tumor with unknown pathogenesis. Herein, we report a case of a hepatic EHE presenting synchronously with a hepatocellular carcinoma (HCC). To the best of our knowledge, this is the second case report of synchronous hepatic EHE and HCC. An 84-year-old man presented with back pain. During examination, a tumor in liver segment 3 was coincidentally detected. Tumor marker (carbohydrate antigen 19-9, alpha-fetoprotein, and protein induced by vitamin K absence or antagonist-II) levels were elevated. Contrast-enhanced computed tomography revealed perinodular enhancement in the arterial and portal phases. Another tumor was detected in liver segment 2, which was homogeneously enhanced in the arterial phase, followed by washout in the portal and late phases. Based on these imaging findings, we diagnosed the tumor in segment 3 as a solitary cholangiocellular carcinoma and the tumor in segment 2 as a solitary HCC. Lateral sectionectomy of the liver was performed. Microscopically, spindle-shaped and epithelioid cells were present in the tumor in segment 3. On immunohistochemistry, the tumor cells were positive for CD31 and CD34, focally positive for D2-40, and negative for AE1/AE3. Therefore, the tumor in segment 3 was ultimately diagnosed as an EHE and the tumor in segment 2 as a well-differentiated HCC. Preoperative diagnosis of EHE is difficult owing to the lack of specific findings. Intratumoral calcification, halo sign, and lollipop sign are occasionally found in EHE and are useful imaging findings for diagnosis. Clinical behavior is unpredictable, ranging from indolent growth to rapid progression. Clinical or pathological predictors of the course of EHE are urgently required.


Surgery Today ◽  
2011 ◽  
Vol 41 (9) ◽  
pp. 1270-1274 ◽  
Author(s):  
Naoya Ikeda ◽  
Kuniyuki Oka ◽  
Nobuo Yonekawa ◽  
Hideya Takaku ◽  
Toshishige Suzuki ◽  
...  

1997 ◽  
Vol 30 (7) ◽  
pp. 1776-1779
Author(s):  
Chifumi Maruyama ◽  
Masakazu Yamamoto ◽  
Masashi Tsugita ◽  
Takehito Otsubo ◽  
Hideo Katsuragawa ◽  
...  

2020 ◽  
Vol 27 (6) ◽  
pp. 429-433
Author(s):  
João Vasco Barreira ◽  
Nádia Silva ◽  
Anuraj Parmanande ◽  
Manuel Rocha ◽  
João S. Coelho ◽  
...  

Fibrolamellar carcinoma is a rare variant of hepatocellular carcinoma not associated with cirrhosis or viral hepatitis. Serum alpha-fetoprotein levels are usually normal; the histology is of a well-differentiated tumor, and the staging is the same as for hepatocellular carcinoma. We describe the case of a female patient in her 4th decade of life with a diagnosis of fibrolamellar hepatocellular carcinoma with a multimodal approach. The rare incidence of this cancer and its unusual clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the treatment of cancer patients.


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