Multicentric & hypovascular hepatocellular carcinoma and its relationship to pathological findings.

Kanzo ◽  
1986 ◽  
Vol 27 (6) ◽  
pp. 802-809
Author(s):  
Masahiro SUENAGA ◽  
Masumasa HORISAWA ◽  
Akimasa NAKAO ◽  
Toshiaki NONAMI ◽  
Akio HARADA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pathological Findings

scholarly journals Pathologic validation of an yttrium-90 trans-arterial radioembolization dosimetry: a case report

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Jacqueline B Baikovitz ◽  
Lindsay Thornton ◽  
Monica T Garcia-Buitrago ◽  
Alan S Livingstone ◽  
Matthew T Studenski ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Liver Resection ◽  
Pathologic Response ◽  
Clinical Scenario ◽  
Complete Pathologic Response ◽  
Pathological Findings ◽  
Rigorous Approach ◽  
Yttrium 90

Abstract Yttrium-90 (Y-90) trans-arterial radioembolization (TARE) is used in the management of unresectable hepatocellular carcinoma (HCC). During the last 5 years, dosimetry software has been developed to allow for a more rigorous approach of dose prescription in Y-90 TARE. We present here a case study of a 77-year-old woman diagnosed with HCC, who underwent a Y-90 TARE as a bridge procedure to liver resection. This clinical scenario represents a unique opportunity to illustrate the predictive value of dosimetric findings correlating dosimetry with pathological findings. In this case, Y-90 TARE dosimetry was predictive of treatment response in which the tumor received a mean dose of 156 Gy and demonstrated a complete pathologic response.

Atypical hemangioma mimicking hepatocellular carcinoma with a special note on radiological and pathological findings

2009 ◽  
Vol 27 (3) ◽  
pp. 156-160 ◽  
Author(s):  
Masakatsu Tsurusaki ◽  
Ryota Kawasaki ◽  
Masato Yamaguchi ◽  
Koji Sugimoto ◽  
Takumi Fukumoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pathological Findings

Detection of hepatocellular carcinoma capsule by contrast-enhanced ultrasound using Levovist: correlations with pathological findings

2005 ◽  
Vol 32 (4) ◽  
pp. 167-172 ◽  
Author(s):  
Pabitra K. Bhattacharjee ◽  
Akiko Saito ◽  
Michiyo Chiba ◽  
Hideo Katsuragawa ◽  
Ken Takasaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Contrast Enhanced Ultrasound ◽  
Pathological Findings ◽  
Contrast Enhanced

scholarly journals Histological Correlation for Radiofrequency and Microwave Ablation in the Local Control of Hepatocellular Carcinoma (HCC) before Liver Transplantation: A Comprehensive Review

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 104
Author(s):  
Peiman Habibollahi ◽  
Rahul A. Sheth ◽  
Erik N. K. Cressman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Microwave Ablation ◽  
Liver Tumors ◽  
High Specificity ◽  
Lesion Size ◽  
Ablation Techniques ◽  
High Rate ◽  
Pathological Findings ◽  
Comprehensive Review

Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most widely studied and applied ablation techniques for treating primary and secondary liver tumors. These techniques are considered curative for small hepatic tumors, with post-ablation outcomes most commonly assessed by an imaging follow up. However, there is increasing evidence of a discrepancy between radiological and pathological findings when ablated lesions are evaluated following liver resection or liver transplantation. A comprehensive review of the available literature reporting the complete pathological response (cPR) following RFA and MWA was performed to estimate the success rate and identify the factors associated with treatment failure. Following RFA, cPR is reported in 26–96% of tumors compared to 57–95% with MWA. Larger tumor size and vessels larger than 3 mm adjacent to the treated tumor are the most important factors identified by previous studies associated with viable residual tumors after RFA. Correlating post-ablation radiological studies with pathological findings shows that computed tomography (CT) and magnetic resonance imaging (MRI) have low sensitivity but high specificity for detecting residual viable or recurrent hepatocellular carcinoma (HCC) tumors. There are promising recent reports combining multiprobe ablation techniques with three-dimensional treatment planning software and stereotactic-aiming instrumentation to achieve more than 90% cPR in both small and large HCC tumors. In conclusion, the reported success for achieving cPR in HCC following RFA and MWA is highly variable in different studies and decreases with increasing lesion size and unfavorable tumor characteristics. Very few studies have reported a high rate of cPR. As these studies are single-center and retrospective, they need to be further validated and reproduced in other clinical settings.

scholarly journals Extension of Hepatocellular Carcinoma. A Comparative Study of Preoperative Hepatic Imagings and Pathological Findings of Resected Specimens.

1992 ◽  
Vol 25 (4) ◽  
pp. 1171-1174
Author(s):  
Takashi Kanematsu ◽  
Takashi Matsumata ◽  
Motoyuki Yamagata ◽  
Eisuke Adachi ◽  
Yasuharu Ikeda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Comparative Study ◽  
Pathological Findings

scholarly journals Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2250
Author(s):  
Peihua Wang ◽  
Fang Nie ◽  
Tiantian Dong ◽  
Dan Yang ◽  
Ting Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Predictive Value ◽  
Malignant Tumors ◽  
High Sensitivity ◽  
High Specificity ◽  
Diagnostic Value ◽  
Arterial Phase ◽  
Liver Imaging ◽  
Pathological Findings ◽  
Focal Lesions

Purpose: To explore the diagnostic value of Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System version 2017 (CEUS LI-RADS v2017) in differentiating alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) from other primary malignancies (OM) of the liver. Methods: The data of 99 patients with primary liver malignant tumors confirmed by surgical pathology and AFP-negative from January 2018 to January 2021 were retrospectively analyzed, and the lesions were divided into 61 cases in the AFP-negative HCC group and 38 cases in the OM group according to the pathological findings, the CEUS features of the lesions were analyzed and the lesions were classified according to the CEUS LI-RADS v2017. Comparison of CEUS features between the two groups was performed using the χ2 test. The sensitivity, specificity, positive predictive value, negative predictive value, and coincidence rate of CEUS LI-RADS v2017 for the diagnosis of AFP-negative HCC and OM were calculated using pathological findings as the gold standard. Results: The differences in features of arterial phase enhancement and wash-out between the HCC and OM groups were statistically significant (p < 0.05). The sensitivity of diagnosing HCC by LR-5 was 62.3% and the specificity was 92.1%. The sensitivity of diagnosing OM by LR-M was 92.1% and the specificity was 83.6%. Conclusions: When AFP is negative in patients with intrahepatic focal lesions, LR-5 has high specificity but low sensitivity in the diagnosis of HCC, and LR-M has high sensitivity and specificity in the diagnosis of OM. CEUS LI-RADS is a tool to differentiate AFP-negative HCC and OM effectively.

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