scholarly journals Level of Stress in Students with the Disturbance of Nasal Breathing and Comorbid Disorders

2019 ◽  
Vol 4 (5) ◽  
pp. 68-72
Author(s):  
L. S. Evert ◽  
I. A. Ignatova ◽  
O. I. Zaitseva ◽  
S. N. Shilov ◽  
N. A. Lisova
Keyword(s):  
Abdominal Pain ◽  
Social Factors ◽  
High Frequency ◽  
Progressive Increase ◽  
Comorbid Disorders ◽  
Nasal Breathing ◽  
Panic Disorders ◽  
Breathing Disorders ◽  
High Level ◽  
Nasal Diseases

Background. The progressive increase of the number of schoolchildren with adaptation disorders and low level of health in recent years determines the need to assess the characteristics of the psychosomatic status in children and adolescents with various types of somatic pathology, including diseases of ENT organs, accompanied by nasal breathing disorders and hypoxia. It is also necessary to determine the severity of stress in children, for timely prevention and correction of these disorders.Aim:to assess the level of stress in schoolchildren with nasal breathing disorders against the background of nasal diseases and concomitant psychosomatic disorders.Materials and methods. 481 schoolchildren aged 12–17 (boys and girls) were examined. Nasal breathing disorders were assessed by a comprehensive ENT examination, including rhinoscopy, radiography of the sinuses, and olfactometry. The presence and severity of stress were determined by the questionnaire “Social factors and stress”.Results. We found that the high level of stress in children with nasal breathing disorders on the background of ENT pathology is more often associated with the high frequency and severity of psychosomatic symptoms: the presence of dorsalgia, asthenic syndrome, chronic headache and frequent episodes of abdominal pain. Moderately and significantly increased levels of stress associated with the presence of children with hypertension, asthenic syndrome, frequent abdominal pain, frequent pain in the cervical spine, panic disorders.Conclusions. Thus, the presence of certain psychosomatic complaints in children with nasal breathing disorders is directly related to the level of stress, which is important to take into account when planning preventive and corrective measures aimed at increasing the adaptive capacity and stress resistance of children. The studies illustrate the need to assess the psychosomatic status and the level of stress in schoolchildren with nasal breathing disorders taking into account their existing comorbid disorders of the psychosomatic spectrum. 

scholarly journals Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chris Donnelly ◽  
Jonathan Stegmüller ◽  
Anthony J. Blazevich ◽  
Fabienne Crettaz von Roten ◽  
Bengt Kayser ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
High Frequency ◽  
Neuromuscular Electrical Stimulation ◽  
Motor Units ◽  
Progressive Increase ◽  
Great Promise ◽  
Measured Parameter ◽  
Time Integral ◽  
Spinal Circuitry ◽  
Evoked Force

AbstractThe effectiveness of neuromuscular electrical stimulation (NMES) for rehabilitation is proportional to the evoked torque. The progressive increase in torque (extra torque) that may develop in response to low intensity wide-pulse high-frequency (WPHF) NMES holds great promise for rehabilitation as it overcomes the main limitation of NMES, namely discomfort. WPHF NMES extra torque is thought to result from reflexively recruited motor units at the spinal level. However, whether WPHF NMES evoked force can be modulated is unknown. Therefore, we examined the effect of two interventions known to change the state of spinal circuitry in opposite ways on evoked torque and motor unit recruitment by WPHF NMES. The interventions were high-frequency transcutaneous electrical nerve stimulation (TENS) and anodal transcutaneous spinal direct current stimulation (tsDCS). We show that TENS performed before a bout of WPHF NMES results in lower evoked torque (median change in torque time-integral: − 56%) indicating that WPHF NMES-evoked torque might be modulated. In contrast, the anodal tsDCS protocol used had no effect on any measured parameter. Our results demonstrate that WPHF NMES extra torque can be modulated and although the TENS intervention blunted extra torque production, the finding that central contribution to WPHF NMES-evoked torques can be modulated opens new avenues for designing interventions to enhance WPHF NMES.

FEATURES OF CAPILLARY BLOOD FLOW IN PATIENTS WITH PATHOLOGY OF INTRANASAL STRUCTURES AND NASAL BREATHING DISORDERS

2020 ◽  
pp. 53-59
Author(s):  
N. O. Shushliapina ◽  
O. Ye. Cherniakova
Keyword(s):  
Blood Flow ◽  
Vascular Tissue ◽  
Circulatory System ◽  
Capillary Blood ◽  
The State ◽  
Capillary Blood Flow ◽  
Nasal Breathing ◽  
Breathing Disorders ◽  
Special Software ◽  
Capillary Circulation

The investigation of the vascular microcirculation system is important for diagnosis, assessment of the severity and nature of pathological processes in human body, monitoring the effectiveness of treatment. Monitoring the state of microcirculation in impaired respiratory function of the nose helps to study the subtle mechanisms of regulation of vascular−tissue relations. To do this, there were used the biomicroscopic methods to study capillary blood flow, one of the most relevant and promising is optical capillaroscopy of the nail bed. This method makes it possible to identify at the evidence level the peculiarities of the functioning of the peripheral circulatory system by the state of the capillary system and to evaluate the effectiveness of treatment by the rheological properties of blood in hematological practice. There were examined 145 patients by means of computer capillaroscopy to study the rate of capillary circulation in the patients with pathology of intranasal structures and nasal breathing disorders. All patients underwent a complete clinical examination, routine instrumental examinations, and computer capillaroscopy using a video capillaroscope with a visual magnification of up to 550 times. The obtained images were stored and processed according to a special software. During the characterization of the capillaroscopic picture there were evaluated: pathological tortuosity, change in the caliber of arterioles and venules, disorganization of the capillary network, the number of functioning capillaries. Changes in the speed and nature of capillary blood flow (accelerated, slow, stasis) were observed. The optical capillaroscopy method allows not only to visually assess the condition of microvessels, but also to determine such an important parameter as blood circulation, actually, it can replace the study of laser Doppler. Such data will be important in the diagnosis of respiratory and olfactory disorders and the formation of adequate tactics for their treatment. Key words: microcirculation, microcirculatory tract, capillary circulation, nasal obstruction, nasal breathing disorders, pathology of intranasal structures, computer capillaroscopy.

Mortality Following Trajectories of Mobility Limitations: The Modifying Impact of Social Factors

2018 ◽  
Vol 32 (3-4) ◽  
pp. 134-142
Author(s):  
Terese Sara Høj Jørgensen ◽  
Volkert Siersma ◽  
Rikke Lund ◽  
Charlotte Juul Nilsson
Keyword(s):  
Older Adults ◽  
Social Factors ◽  
Regression Models ◽  
Age Group ◽  
Mobility Limitations ◽  
Hazard Regression ◽  
Trajectory Modeling ◽  
High Level ◽  
Method Group

Objective: How are trajectories of mobility limitations (MLs) among older adults associated with mortality? Do social factors modify these associations? Method: Group-based trajectory modeling was used to identify four trajectories of MLs over a period of 4.5 years among 3,055 older Danes. Mortality analyses were conducted using additive hazard regression models. Results: Compared to older adults without MLs, older adults with high level of MLs who experienced further increase in MLs were associated with the most additional deaths followed by older adults with no MLs at baseline who later experienced limitations and older adults with a medium ML level at baseline who later experienced further increase in limitations. Men and 80-year olds experienced more additional deaths following adverse ML trajectories than women and 75-year olds. Discussion: Trajectories that led to higher ML levels were associated with most additional deaths especially among men and in the oldest age group.

scholarly journals Optimization of evaluation human tendecy for alcohol consumption

2016 ◽  
Vol 24 (4) ◽  
pp. 6-16
Author(s):  
A B Mulik ◽  
S V Bulatetsky ◽  
I V Ulesikova ◽  
I G Mulik ◽  
E V Nazarova ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Abuse ◽  
Social Factors ◽  
Integrated System ◽  
Psychoactive Substances ◽  
Social Risks ◽  
Teenagers And Young Adults ◽  
Differentiation Degree ◽  
Positive Feelings ◽  
High Level

The problem of alcohol consumption is one of the major causes of depopulation in the Russian Federation. The particular concern is the alcoholism of teenagers and young adults. Substantiates the relevance of complex factors influence the biological and social risks of substance use among youth. Objective: To develop an integrated system approach predicting human risk of alcohol abuse, combining the functional assessment, psychological and social factors in the formation of demand for psychoactive substances. As the object of the study 89 people of both sexes were involved, 18-23 years of age, students of Volgograd State University. The work was performed in accordance with Articles 5, 6 and 7 "on Bioethics and Human Rights, the Universal Declaration” with registration of informed consent. As a result of complex investigations undertaken identified a number of positions of principle capable of predicting the risk of alcohol abuse human. At the same time, it justified the increased susceptibility to alcohol consumption in individuals with a high level of general non-specific reactivity (UONRO). It revealed highly significant effect of negative feelings from the first samples of alcohol to block alcohol abuse human motivations. At the same time, positive feelings of alcohol during the first trial, significantly increase the risk of alcoholism. It was determined that the vast majority of respondents (95%) did not consume alcohol, brought up in the families of non-drinking parents. In contrast, respondents - consumers of alcohol, in 62% of cases vopityvalis in alcoholic families traditions. Thus, the facts revealed dependence on the combination of alcohol consumption UONRO indicators of psychosomatic condition of the person as a result of the first sample of alcohol and attitudes of members of the parental family to consume alcohol. Based on these data provided a method for predicting the risk of alcohol consumption, which provides a comprehensive account of the functional, psychological and social factors in the formation of demand for psychoactive substances, the possibility of a qualitative typology and differentiation degree of risk of alcohol abuse and algorithmization testing process.

scholarly journals The effects of nasal breathing on the development of snoring and apnea

2020 ◽  
pp. 89-94
Author(s):  
Svetlana E. Yaremchuk
Keyword(s):  
Sleep Quality ◽  
Nasal Congestion ◽  
Upper Airway ◽  
Case Control Studies ◽  
Nasal Breathing ◽  
Adequate Treatment ◽  
Randomized Controlled ◽  
Breathing Disorders ◽  
Nasal Steroids ◽  
Improve Sleep Quality

Since the nose is the entrance gate of the upper airway, its stuffiness can contribute to sleep disturbance. The results of a number of case-control studies have shown that nasal congestion frequency associated with snoring and mild OSA. However, there is no strong correlation between the degree of nasal obstruction and the severity of OSA. Randomized controlled trials have shown that in patients with rhinitis, both allergic and non-allergic, the use of nasal steroids can improve sleep quality and may be useful for patients with mild OSA, but they themselves are not an adequate treatment. Surgical correction of nasal breathing disorders also reduces the apnea index and improves sleep quality.

scholarly journals Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region

2019 ◽  
Vol 121 (3) ◽  
pp. 1018-1033 ◽  
Author(s):  
C. Lee ◽  
J. J. Guinan ◽  
M. A. Rutherford ◽  
W. A. Kaf ◽  
K. M. Kennedy ◽  
...  
Keyword(s):  
High Frequency ◽  
Action Potentials ◽  
Tuning Curve ◽  
Low Frequency ◽  
Sound Level ◽  
Frequency Tone ◽  
Compound Action Potentials ◽  
High Level ◽  
Level Tone ◽  
Compound Action

Little is known about the spatial origins of auditory nerve (AN) compound action potentials (CAPs) evoked by moderate to intense sounds. We studied the spatial origins of AN CAPs evoked by 2- to 16-kHz tone bursts at several sound levels by slowly injecting kainic acid solution into the cochlear apex of anesthetized guinea pigs. As the solution flowed from apex to base, it sequentially reduced CAP responses from low- to high-frequency cochlear regions. The times at which CAPs were reduced, combined with the cochlear location traversed by the solution at that time, showed the cochlear origin of the removed CAP component. For low-level tone bursts, the CAP origin along the cochlea was centered at the characteristic frequency (CF). As sound level increased, the CAP center shifted basally for low-frequency tone bursts but apically for high-frequency tone bursts. The apical shift was surprising because it is opposite the shift expected from AN tuning curve and basilar membrane motion asymmetries. For almost all high-level tone bursts, CAP spatial origins extended over 2 octaves along the cochlea. Surprisingly, CAPs evoked by high-level low-frequency (including 2 kHz) tone bursts showed little CAP contribution from CF regions ≤ 2 kHz. Our results can be mostly explained by spectral splatter from the tone-burst rise times, excitation in AN tuning-curve “tails,” and asynchronous AN responses to high-level energy ≤ 2 kHz. This is the first time CAP origins have been identified by a spatially specific technique. Our results show the need for revising the interpretation of the cochlear origins of high-level CAPs-ABR wave 1. NEW & NOTEWORTHY Cochlear compound action potentials (CAPs) and auditory brain stem responses (ABRs) are routinely used in laboratories and clinics. They are typically interpreted as arising from the cochlear region tuned to the stimulus frequency. However, as sound level is increased, the cochlear origins of CAPs from tone bursts of all frequencies become very wide and their centers shift toward the most sensitive cochlear region. The standard interpretation of CAPs and ABRs from moderate to intense stimuli needs revision.

Control of respiratory activity of the genioglossus muscle in micrognathic infants

1986 ◽  
Vol 61 (4) ◽  
pp. 1523-1533 ◽  
Author(s):  
J. L. Roberts ◽  
W. R. Reed ◽  
O. P. Mathew ◽  
B. T. Thach
Keyword(s):  
Upper Airway ◽  
Esophageal Pressure ◽  
Progressive Increase ◽  
Emg Activity ◽  
Nasal Breathing ◽  
Airway Patency ◽  
Tongue Muscle ◽  
Airway Occlusion ◽  
Pharyngeal Airway ◽  
Obstructive Sleep

The genioglossus (GG) muscle activity of four infants with micrognathia and obstructive sleep apnea was recorded to assess the role of this tongue muscle in upper airway maintenance. Respiratory air flow, esophageal pressure, and intramuscular GG electromyograms (EMG) were recorded during wakefulness and sleep. Both tonic and phasic inspiratory GG-EMG activity was recorded in each of the infants. On occasion, no phasic GG activity could be recorded; these silent periods were unassociated with respiratory embarrassment. GG activity increased during sigh breaths. GG activity also increased when the infants spontaneously changed from oral to nasal breathing and, in two infants, with neck flexion associated with complete upper airway obstruction, suggesting that GG-EMG activity is influenced by sudden changes in upper airway resistance. During sleep, the GG-EMG activity significantly increased with 5% CO2 breathing (P less than or equal to 0.001). With nasal airway occlusion during sleep, the GG-EMG activity increased with the first occluded breath and progressively increased during the subsequent occluded breaths, indicating mechanoreceptor and suggesting chemoreceptor modulation. During nasal occlusion trials, there was a progressive increase in phasic inspiratory activity of the GG-EMG that was greater than that of the diaphragm activity (as reflected by esophageal pressure excursions). When pharyngeal airway closure occurred during a nasal occlusion trial, the negative pressure at which the pharyngeal airway closed (upper airway closing pressure) correlated with the GG-EMG activity at the time of closure, suggesting that the GG muscle contributes to maintaining pharyngeal airway patency in the micrognathic infant.

scholarly journals Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance

2008 ◽  
Vol 53 (1) ◽  
pp. 193-201 ◽  
Author(s):  
Kozo Ochi ◽  
Ji-Yun Kim ◽  
Yukinori Tanaka ◽  
Guojun Wang ◽  
Kenta Masuda ◽  
...  
Keyword(s):  
16S Rrna ◽  
High Frequency ◽  
Resistance Mutations ◽  
Gene Encoding ◽  
Adenosylmethionine Decarboxylase ◽  
Ribosomal Function ◽  
High Level ◽  
Antibiotic Resistance Mutations ◽  
Modest Level ◽  
Level Resistance

ABSTRACT The methyltransferases RsmG and KsgA methylate the nucleotides G535 (RsmG) and A1518 and A1519 (KsgA) in 16S rRNA, and inactivation of the proteins by introducing mutations results in acquisition of low-level resistance to streptomycin and kasugamycin, respectively. In a Bacillus subtilis strain harboring a single rrn operon (rrnO), we found that spontaneous ksgA mutations conferring a modest level of resistance to kasugamycin occur at a high frequency of 10−6. More importantly, we also found that once cells acquire the ksgA mutations, they produce high-level kasugamycin resistance at an extraordinarily high frequency (100-fold greater frequency than that observed in the ksgA + strain), a phenomenon previously reported for rsmG mutants. This was not the case for other antibiotic resistance mutations (Tspr and Rifr), indicating that the high frequency of emergence of a mutation for high-level kasugamycin resistance in the genetic background of ksgA is not due simply to increased persistence of the ksgA strain. Comparative genome sequencing showed that a mutation in the speD gene encoding S-adenosylmethionine decarboxylase is responsible for the observed high-level kasugamycin resistance. ksgA speD double mutants showed a markedly reduced level of intracellular spermidine, underlying the mechanism of high-level resistance. A growth competition assay indicated that, unlike rsmG mutation, the ksgA mutation is disadvantageous for overall growth fitness. This study clarified the similarities and differences between ksgA mutation and rsmG mutation, both of which share a common characteristic—failure to methylate the bases of 16S rRNA. Coexistence of the ksgA mutation and the rsmG mutation allowed cell viability. We propose that the ksgA mutation, together with the rsmG mutation, may provide a novel clue to uncover a still-unknown mechanism of mutation and ribosomal function.

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