scholarly journals Elaboration of New Medical Technology for Predicting the Risk of Ischemic Heart Disease in the Workers of the Coal Industry

2019 ◽  
Vol 4 (3) ◽  
pp. 52-57 ◽  
Author(s):  
N. I. Panev ◽  
S. N. Filimonov ◽  
O. Yu. Korotenko ◽  
R. N. Panev ◽  
N. Ya. Paneva
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Markers ◽  
Medical Technology ◽  
Density Lipoprotein ◽  
Morphological Type ◽  
Coal Industry ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein

Background. Ischemic heart disease is the leading cause of death in the majority of developed countries, including Russia. It determines the importance of elaboration of individual risk prediction of ischemic heart disease for primary prevention.Aim: to develop a strategy for predicting the ischemic heart disease in coal industry workers.Materials and methods. Ischemic heart disease incidence and its risk factors were studied in 196 coalmine workers (sinkers, stope miners). Rose Questionnaire, daily ECG monitoring and bicycle ergometry were used to detect angina. The indices of lipid metabolism, hemostatic system, the level of homocysteine, uric acid, C-reactive protein, constitutional-morphological type by Rees – Eysenck, genetic markers of blood groups of AB0, P and MN systems were studied.When elaborating the prognostic system, we used the Bayes method. A prognostic coefficient was calculated for each factor. Prediction of ischemic heart disease was carried out according to the sum of prognostic coefficients.Results. Ischemic heart disease was detected in 18 (9.2 %) miners. According to the above mentioned indices, a medical technology was elaborated to predict the ischemic heart disease, based on the determination of the most significant risk markers: age, work experience in harmful working conditions, type A behavior, arterial hypertension, fasting hyperglycemia, metabolic syndrome, hypercholesterolemia, decrease in the level of high density lipoprotein cholesterol, increase in the value of low density lipoprotein cholesterol, hypertriglyceridemia, hyperhomocysteinemia, hyperfibrinogenemia, increase in the level of soluble fibrin monomer complexes and C-reactive protein, abdominal obesity, hypersthenic constitutional-morphological type by Rees – Eysenck, genetic markers of blood groups of AB0, P and MN systems.Conclusion. Based on the most significant markers, a personalized strategy for ischemic heart disease prediction in miners was elaborated, which allowed timely undertaking therapeutic and preventive measures.

GENETICALLY ELLEVATED C-REACTIVE PROTEIN AND ISCHEMIC HEART DISEASE: THREE MENDELIAN RANDOMIZATION STUDIES

2008 ◽  
Vol 9 (1) ◽  
pp. 81
Author(s):  
J. Zacho ◽  
A. Tybjaerg-Hansen ◽  
J. SkovJensen ◽  
P. Grande ◽  
B.G. Nordestgaard
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Mendelian Randomization ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein, Fibrin D-Dimer, and Incident Ischemic Heart Disease in the Speedwell Study

2001 ◽  
Vol 21 (4) ◽  
pp. 603-610 ◽  
Author(s):  
Gordon D. O. Lowe ◽  
John W. G. Yarnell ◽  
Ann Rumley ◽  
David Bainton ◽  
Peter M. Sweetnam
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
D Dimer

Risk factors for coronary heart disease in miners with anthracosilicosis

2021 ◽  
Vol 61 (3) ◽  
pp. 161-167
Author(s):  
Nikolay I. Panev ◽  
Natalya A. Evseeva ◽  
Sergey N. Filimonov ◽  
Olga Yu. Korotenko ◽  
Olga N. Blazhina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Significant Risk ◽  
Morphological Type ◽  
Coal Industry ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein

Introduction. There are data on the effects of dust on the respiratory system and the cardiovascular system. The main measures for preventing diseases of the circulatory system aimed to identify and eliminate risk factors. However, the prevalence of risk factors for coronary heart disease among coal mine workers with anthracosilicosis has not been sufficiently studied, determining the study's relevance. The study aimed to learn the frequency of risk factors for coronary heart disease in coal industry workers with anthracosilicosis. Materials and methods. We examined 269 miners working in conditions of dustiness exceeding the maximum permissible concentration by ten or more times: 139 miners with a previously established diagnosis of anthracosilicosis and 130 miners of the control group without dust pathology of the lungs. All of them underwent a comprehensive clinical, instrumental, and laboratory examination of the respiratory and cardiovascular systems to detect anthracosilicosis and coronary heart disease, as well as to assess its risk factors. Results. In miners with anthracosilicosis, coronary heart disease was 3.5 times more common (30.94%) than in the control group (8.46%). We have identified a high incidence of coronary heart disease in the age group of 45 and more years and with the experience of working in dust conditions of 20 and more years. In miners with anthracosilicosis combined with coronary heart disease, arterial hypertension was 1.6 times more common (58.14%) than without concomitant coronary heart disease - 35.42%. Miners with a combination of anthracosilicosis and coronary heart disease were three times more likely (20.93%) than those without coronary heart disease (6.25%) to have a metabolic syndrome. According to the Tanner index, significant risk factors for coronary heart disease were the presence of an andromorphic constitutional-morphological type and the formation of a complication of anthracosilicosis - respiratory failure. The evaluation of biochemical blood tests showed that the most significant markers of coronary heart disease risk were hyperhomocysteinemia, increased levels of C-reactive protein, fibrinogen, and soluble fibrin-monomer complexes. Conclusions. We found that the most significant risk of developing coronary heart disease in miners is 45 years and older. There are also other risk factors: work experience in harmful working conditions of 20 years or more; the presence of arterial hypertension; metabolic syndrome; andromorphic constitutional-morphological type according to the Tanner index. Risk factors are respiratory failure, hyperhomocysteinemia, hyperfibrinogenemia, increased soluble fibrin-monomer complexes, and C - reactive protein. It is necessary to consider all risks in developing programs of medical and preventive measures for employees of the coal industry.

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