scholarly journals Pelvic Exenteration in Patients with Persistent and Recurrent Cervical Cancer: A Case Series from Belarus

2021 ◽  
Vol 6 (1) ◽  
pp. 1-9
Author(s):  
Olga P. Matylevich ◽  
Kathleen M. Schmeler ◽  
Sergey L. Polyakov ◽  
Siarhei A. Mavrichev ◽  
Irina A. Kosenko ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pelvic Exenteration ◽  
Case Series ◽  
Recurrent Cervical Cancer

Morbidity and mortality of pelvic exenteration for cervical cancer at a German referral center.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17505-e17505
Author(s):  
Jelena Boekhoff ◽  
Luisa terGlane ◽  
Uwe Wagner ◽  
Axel Hegele
Keyword(s):  
Cervical Cancer ◽  
Overall Survival ◽  
Pelvic Exenteration ◽  
Survival Rates ◽  
Operation Time ◽  
Previous Treatment ◽  
University Hospital ◽  
Treatment Modalities ◽  
Complication Rates ◽  
Recurrent Cervical Cancer

e17505 Background: The purpose of this study was to evaluate data regarding the outcome of pelvic exenteration (PE) when performed for advanced or recurring cervical cancer. Methods: A total of 24 patients underwent PE for cervical cancer at the University Hospital Marburg between 2011 and 2016. Their data were retrospectively assessed and statistically analyzed. Survival was evaluated using the Kaplan-Meyer method. Results: Mean age was 52.2 years (29.7 to 72.6 years), mean BMI was 23.4 kg/m2. Most common indication was squamous cell carcinoma, whereas 3 patients underwent PE for adenocarcinoma. The majority of the tumors (62.5%) were stage pT4. Negative margins could be achieved in 70.8%. Lymph nodes could be assessed in 55% and were tumor-afflicted in 20.8%. 45.8% were treated for recurrent cancer; median recurrence free time between previous treatment and PE was 16 months. Up-front PE was performed in 20.8%. Another 79.2% received treatment prior to PE: 20.8% received all 3 treatment modalities whereas 37.5% had two treatments before (29.2% underwent chemo- and radiotherapy, 8.3% had surgery and radiotherapy) and 20.8% underwent one type of treatment. Anterior PE (APE) and total PE (TPE) were performed in 62.5% and 37.5%, respectively. Median operation time was 324min. Blood products were administered perioperatively in 75%; 37.5% needed 2 or more. Median hospital stay was 25 days. Major complications (Clavien Dindo≥3) were observed in 41.7% and 16.7% had no complications. Overall Survival (OS) was 29.2%; median overall survival was 19.1 months. 2- and 3-year survival rates for curative PE were 50% and 35% respectively. 4 patients underwent PE with palliative intent. Overall survival correlated significantly with R1- (p = 0.012), N1- (p = 0.047) and M1-status p < 0.01), TPE (p = 0.034) and surgical time > 6 h (p = 0.003). Conclusions: In cases of advanced or recurrent cervical cancer gynecologists struggle to find suitable therapeutic options, especially since most patients have already received radio- and/or chemotherapy. PE is a valid option for selected patients that may represent a cure with tolerable complication rates.

Survival After Curative Pelvic Exenteration for Primary or Recurrent Cervical Cancer: A Retrospective Multicentric Study of 167 Patients

2014 ◽  
Vol 24 (5) ◽  
pp. 916-922 ◽  
Author(s):  
Vito Chiantera ◽  
Martina Rossi ◽  
Pierandrea De Iaco ◽  
Christardt Koehler ◽  
Simone Marnitz ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Pelvic Exenteration ◽  
Cell Cancer ◽  
Pelvic Lymph Node ◽  
Term Survival ◽  
Primary Tumors ◽  
Multicentric Study ◽  
Recurrent Cervical Cancer

ObjectiveEvaluate the survival of patients who underwent pelvic exenteration (PE) with curative intent for primary persistent or recurrent cervical cancer.MethodsWe retrospectively investigated 167 consecutive patients, referred to the gynecological oncology units of 4 centers in Germany or Italy, who underwent PE. Data regarding surgery, histology, and oncologic outcomes were collected and statistically evaluated. Survival was determined from the day of exenteration until last follow-up or death.ResultsThe median age was 51 years. Twenty-seven patients (16.2%) underwent PE owing to advanced primary tumors (group A), 34 patients (20.4%) underwent PE owing to persistent cancer after chemotherapy or chemoradiation (group B), and 106 patients (63.4%) underwent PE owing to recurrence (group C). The prevalent histologic type was squamous cell cancer. A complete tumor resection (R0), was achieved in 121 patients (72.5%). Forty-nine patients (29.3%) had pelvic lymph node metastases and 44 patients (26.3%) had pelvic sidewall involvement. Overall survival at the end of the study was 40.7%. The cumulative 5-year overall survival for the entire cohort was 38%. Resection margins, pelvic lymph node state, and sidewall involvement were independent prognostic factors in multivariate analysis.ConclusionPelvic exenteration is a valid therapeutic option for patients with locally advanced primary persistent or recurrent cervical cancer, with a long-term survival in 40% of the patients.

RE: Panniculectomy concurrent with anterior pelvic exenteration for recurrent cervical cancer

2008 ◽  
Vol 110 (2) ◽  
pp. 269
Author(s):  
Debra L. Richardson ◽  
Leigh G. Seamon ◽  
David E. Cohn
Keyword(s):  
Cervical Cancer ◽  
Pelvic Exenteration ◽  
Recurrent Cervical Cancer

Resection of recurrent cervical cancer after total pelvic exenteration

2007 ◽  
Vol 17 (1) ◽  
pp. 137-140 ◽  
Author(s):  
S. M. Mourton ◽  
Y. Sonoda ◽  
N. R. Abu-Rustum ◽  
B. H. Bochner ◽  
R. R. Barakat ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Median Time ◽  
Pelvic Exenteration ◽  
Femoral Nerve ◽  
Psoas Muscle ◽  
Total Pelvic Exenteration ◽  
Recurrent Cervical Cancer ◽  
Time To Recurrence ◽  
Initial Recurrence ◽  
Alive With Disease

The objective of this study was to describe the management of patients with recurrent cervical cancer after total pelvic exenteration (TPE). We reviewed the records of patients who underwent TPE for recurrent cervical cancer between June 1992 and December 2003 and subsequently developed recurrent disease. Thirty-seven patients underwent TPE during the study period, and 25 (68%) subsequently developed recurrence proven by radiographic and/or biopsy studies. Recurrence sites included pelvic (12), inguinal (5), retroperitoneal (5), hepatic (4), vulva (2), perineum (1), transposed ovary (1), and lung (1). The median time to recurrence was 7 months (range 2–73 months), with 92% (23/25) occurring within 2 years of TPE. Management of recurrence was known in 21 of 25 patients, which included chemotherapy (10), surgical resection (7), and no further treatment (4). Surgically resected recurrences were isolated to the groin (2), vulva (2), perineum (1), transposed ovary (1), and psoas muscle (1). The four patients who underwent ovarian, perineal, and vulvar resections succumbed to their disease in a median time of 13 months (range 2–21 months). Of the two patients with surgically resected groin recurrences, one is alive with disease 21 months after initial recurrence and the other is alive without evidence of disease 85 months later. One patient had an isolated 4-cm recurrence involving the psoas muscle and the femoral nerve and is without the evidence of disease 9 months later. Resection of isolated recurrences after TPE is a reasonable option in selected patients, particularly in those with solitary inguinal metastases

Panniculectomy concurrent with anterior pelvic exenteration for recurrent cervical cancer

2008 ◽  
Vol 110 (2) ◽  
pp. 268-269 ◽  
Author(s):  
Charles A. Leath ◽  
Michael E. Decherd ◽  
James L. Wilder
Keyword(s):  
Cervical Cancer ◽  
Pelvic Exenteration ◽  
Recurrent Cervical Cancer
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