scholarly journals In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line

2019 ◽  
Vol 22 (5) ◽  
pp. 264-277
Author(s):  
Mahtab Pourkamalzadeh ◽  
◽  
Seyid Mesam Abtahi froushani ◽  
Keyword(s):  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Apoptotic Effects

scholarly journals Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo

2010 ◽  
Vol 9 (11) ◽  
pp. 875-884 ◽  
Author(s):  
Lin Deng ◽  
Gang Li ◽  
Ronghui Li ◽  
Qinglin Liu ◽  
Qiaowei He ◽  
...  
Keyword(s):  
Cell Line ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Rho Kinase Inhibitor

Hybrid cholesterol-based nanocarriers containing phosphorescent Ir complexes: in vitro imaging on glioblastoma cell line

RSC Advances ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 1091-1096 ◽  
Author(s):  
Maria Naddaka ◽  
Erica Locatelli ◽  
David Colecchia ◽  
Letizia Sambri ◽  
Ilaria Monaco ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Metal Complexes ◽  
Cell Line ◽  
Research Field ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Line P

Recently the use of phosphorescent heavy-metal complexes in bioimaging techniques has been a promising research field and has been attracted increasing interest.

Pediatric glioblastoma cell line shows different patterns of expression of transmembrane ABC transporters after in vitro exposure to vinblastine

2008 ◽  
Vol 25 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Elvis Terci Valera ◽  
Maria Angélica Abdalla de Freitas Cortez ◽  
Rosane Gomes de Paula Queiroz ◽  
Fabio Morato de Oliveira ◽  
María Sol Brassesco ◽  
...  
Keyword(s):  
Cell Line ◽  
Abc Transporters ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
In Vitro Exposure ◽  
Pediatric Glioblastoma

scholarly journals SN38 loaded nanostructured lipid carriers (NLCs); preparation and in vitro evaluations against glioblastoma

2021 ◽  
Vol 32 (7) ◽  
Author(s):  
Ali Sabouri Shirazi ◽  
Reyhaneh Varshochian ◽  
Mahsa Rezaei ◽  
Yalda Hosseinzadeh Ardakani ◽  
Rassoul Dinarvand
Keyword(s):  
Cell Line ◽  
Accurate Determination ◽  
In Vitro Release ◽  
Parent Drug ◽  
Entrapment Efficiency ◽  
Nanostructured Lipid Carrier ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Mean Size

AbstractSN38 is the active metabolite of irinotecan with 1000-fold greater cytotoxicity compared to the parent drug. Despite the potential, its application as a drug is still seriously limited due to its stability concerns and low solubility in acceptable pharmaceutical solvents. To address these drawbacks here nanostructured lipid carrier (NLC) containing SN38 was prepared and its cytotoxicity against U87MG glioblastoma cell line was investigated. The formulations were prepared using hot ultrasonication and solvent evaporation/emulsification methods. NLCs with a mean size of 140 nm and particle size distribution (PDI) of 0.25 were obtained. The average loading efficiency was 9.5% and its entrapment efficiency was 81%. In order to obtain an accurate determination of released amount of SN38 a novel medium and extraction method was designed, which lead to an appropriate in vitro release profile of the drug from the prepared NLCs. The MTT test results revealed the significant higher cytotoxicity of NLCs on U87MG human glioblastoma cell line compared with the free drug. The confocal microscopy images confirmed the proper penetration of the nanostructures into the cells within the first 4 h. Consequently, the results indicated promising potentials of the prepared NLCs as a novel treatment for glioblastoma.

Sign in / Sign up

Export Citation Format

Share Document