scholarly journals Effect of Genetic and Environmental Factors on Obesity in Children (Case Study: Qom City)

2019 ◽  
Vol 8 (2) ◽  
pp. 97-106
Author(s):  
Marzie Fatemi Abhari ◽  
Maysam Musai ◽  
◽  
Keyword(s):  
Environmental Factors ◽  
Genetic And Environmental Factors ◽  
Obesity In Children

scholarly journals AYURVEDIC MANAGEMENT OF BRONCHIAL ASTHMA – A CASE STUDY

2020 ◽  
Vol 8 (10) ◽  
pp. 4894-4901
Author(s):  
Momin Jasmin Begam ◽  
Kulkarni Prasad ◽  
Gogate Vishwas
Keyword(s):  
Side Effects ◽  
Environmental Factors ◽  
Bronchial Asthma ◽  
Clinical Picture ◽  
Signs And Symptoms ◽  
Breathing Difficulty ◽  
Systemic Side Effects ◽  
Genetic And Environmental Factors ◽  
Present Case Study

Bronchial asthma is a heterogenous disease with reciprocity between genetic and environmental factors. The different triggering factors increase the frequency and severity of breathing difficulty attacks. The use of modern medicines is restricted due to its various local as well systemic side effects. The clinical picture of bronchial asthma can be correlated with Tamakashwas as explained in Ayurveda. In the present case study, a 24 years old female patient having signs and symptoms of Tamakashwas has been discussed. The treatment was administered in accordance with Shodhana Chikitsa, Shamana Aushadhis and Sthanika Chikitsa. Nidana Parivarjana is strictly instructed in order to avoid the stimulation to internal pathology of the disease. The classical management helps in relieving the symptoms as well as lowers the recurrence of the breathing difficulty attacks. Regular counselling and practice of Parnayama contributes in boosting and refreshing her mind. The assessment was done by using the gradation scale which was adopted from de-veloping guidelines for clinical research methodology in Ayurveda. This Ayurvedic management helps in achieving the positive output with complete stoppage of use of inhaler over a period of 6 months.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study

2017 ◽  
Vol 23 (32) ◽  
pp. 4773-4793 ◽  
Author(s):  
Nivedita Singh ◽  
Sherry Freiesleben ◽  
Olaf Wolkenhauer ◽  
Yogeshwer Shukla ◽  
Shailendra K. Gupta
Keyword(s):  
Drug Target ◽  
Complex Disease ◽  
Biological Targets ◽  
Systems Approaches ◽  
Anticancer Mechanism ◽  
Genetic And Environmental Factors ◽  
Key Steps ◽  
Network Approaches ◽  
Novel Drug

The identification and validation of novel drug–target combinations are key steps in the drug discovery processes. Cancer is a complex disease that involves several genetic and environmental factors. High-throughput omics technologies are now widely available, however the integration of multi-omics data to identify viable anticancer drug-target combinations, that allow for a better clinical outcome when considering the efficacy-toxicity spectrum, is challenging. This review article provides an overview of systems approaches which help to integrate a broad spectrum of technologies and data. We focus on network approaches and investigate anticancer mechanism and biological targets of resveratrol using reverse pharmacophore mapping as an in-depth case study. The results of this case study demonstrate the use of systems approaches for a better understanding of the behavior of small molecule inhibitors in receptor binding sites. The presented network analysis approach helps in formulating hypotheses and provides mechanistic insights of resveratrol in neoplastic transformations.

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