scholarly journals Effect of precipitation inhibitors on supersaturation and solubility of furosemide

2021 ◽  
Vol 25(2) (25(2)) ◽  
pp. 209-217
Author(s):  
Tuğba GÜLSÜN-Naile ÖZTÜRK-Aslı KARA
Keyword(s):  
Precipitation Inhibitors

scholarly journals Combined Use of Crystalline Sodium Salt and Polymeric Precipitation Inhibitors to Improve Pharmacokinetic Profile of Ibuprofen through Supersaturation

2014 ◽  
Vol 15 (5) ◽  
pp. 1334-1344 ◽  
Author(s):  
Jenna L. Terebetski ◽  
John J. Cummings ◽  
Scott E. Fauty ◽  
Bozena Michniak-Kohn
Keyword(s):  
Sodium Salt ◽  
Pharmacokinetic Profile ◽  
Combined Use ◽  
Precipitation Inhibitors

scholarly journals In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System (Super-SNEDDS) of Aprepitant for Enhanced Solubility

2021 ◽  
Vol 14 (11) ◽  
pp. 1089
Author(s):  
Hakan Nazlı ◽  
Burcu Mesut ◽  
Yıldız Özsoy
Keyword(s):  
Drug Delivery ◽  
Aqueous Solubility ◽  
In Vitro Dissolution ◽  
Ternary Phase Diagrams ◽  
Enhanced Solubility ◽  
Porous Carriers ◽  
Drug Precipitation ◽  
Precipitation Inhibitors ◽  
Preformulation Studies

Aprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its low aqueous solubility. The objective of the current work is to develop self-nanoemulsifying drug delivery systems (SNEDDS) of APR to enhance its aqueous solubility. Preformulation studies involving screening of excipients for solubility and emulsification efficiency were carried out. Pseudo ternary phase diagrams were constructed with blends of oil (Imwitor® 988), cosolvent (Transcutol® P), and various surfactants (Kolliphor® RH40, Kolliphor® ELP, Kolliphor® HS15). The prepared SNEDDS were characterized for droplet size and nanoemulsion stability after dilution. Supersaturated SNEDDS (super-SNEDDS) were prepared to increase the quantity of loaded APR into the formulations. HPMC, PVP, PVP/VA, and Soluplus® were used as polymeric precipitation inhibitors (PPI). PPIs were added to the formulations at 5% and 10% by weight. The influence of the PPIs on drug precipitation was investigated. In vitro lipolysis test was carried out to simulate digestion of formulations in the gastrointestinal tract. Optimized super-SNEDDS were formulated into free-flowing granules by adsorption on the porous carriers such as Neusilin® US2. In vitro dissolution studies of solid super-SNEDDS formulation revealed an increased dissolution rate of the drug due to enhanced solubility. Consequently, a formulation to improve the solubility and potentially bioavailability of the drug was developed.

scholarly journals Inhibition of calcium and magnesium carbonate crystallization with sodium polyacrylate

2019 ◽  
Vol 55 (3) ◽  
pp. 377-387
Author(s):  
I. V. Shestak ◽  
A. D. Vorobiev ◽  
D. V. Cherednichenko ◽  
E. V. Vorobyova ◽  
E. V. Laevskaya ◽  
...  
Keyword(s):  
Magnesium Carbonate ◽  
Continuous Heating ◽  
Water Supply Systems ◽  
Sodium Polyacrylate ◽  
X Ray Diffraction ◽  
Calcium Carbonates ◽  
Circulating Water ◽  
Heating And Cooling ◽  
Cleaning Equipment ◽  
Precipitation Inhibitors

It is known that when water are used for technological purposes, in circulating water supply systems of enterprises as a coolant during continuous heating and cooling, the formation of insoluble precipitates, most often calcium carbonates, occurs on the walls of heat exchangers, which leads to a large number of problems, even production can be stopped for cleaning equipment. To prevent the formation of salts, it is necessary to use precipitation inhibitors. Sodium polyacrylate was investigated as a precipitation inhibitor. The composition, morphology and IR spectra of calcium carbonate precipitate obtained in the absence and in the presence of sodium polyacrylate were studied. It was established that the effect of sodium polyacrylate on the mechanism of crystallization of carbonate sediment depends on the pH of the initial solution. The results of IR spectroscopy, X-ray diffraction analysis and images obtained by electron microscopy indicate the participation of polymer molecules in the formation of the crystalline structure of the carbonate precipitate.

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