scholarly journals TRIP Database

2018 ◽  
Vol 39 (3) ◽  
pp. 152-154
Author(s):  
Jackie Phinney
Keyword(s):  
United Kingdom ◽  
Clinical Research ◽  
Research Database ◽  
Sources Of Information ◽  
Multiple Sources ◽  
Single Interface ◽  
The United Kingdom

Based in the United Kingdom, TRIP (Turning Research Into Practice) is a clinical research database that allows users to search across multiple sources of information and publication types using a single interface.

scholarly journals Study protocol: optimising newborn nutrition during and after neonatal therapeutic hypothermia in the United Kingdom: observational study of routinely collected data using propensity matching

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e026739 ◽  
Author(s):  
Cheryl Battersby ◽  
Nick Longford ◽  
Mehali Patel ◽  
Ella Selby ◽  
Shalini Ojha ◽  
...  
Keyword(s):  
United Kingdom ◽  
Therapeutic Hypothermia ◽  
Late Onset ◽  
Standard Of Care ◽  
Blood Stream ◽  
Research Database ◽  
Population Database ◽  
Scientific Publications ◽  
Link Type ◽  
The United Kingdom

IntroductionTherapeutic hypothermia is standard of care for infants born ≥36 weeks gestation with hypoxic ischaemic encephalopathy (HIE); consensus on optimum nutrition during therapeutic hypothermia is lacking. This results in variation in enteral feeding and parenteral nutrition (PN) for these infants. In this study, we aim to determine the optimum enteral nutrition and PN strategy for newborns with HIE during therapeutic hypothermia.Methods and analysisWe will undertake a retrospective cohort study using routinely recorded electronic patient data held on the United Kingdom (UK) National Neonatal Research Database (NNRD). We will extract data from infants born ≥36 weeks gestational age between 1 January 2008 and 31 December 2016, who received therapeutic hypothermia for at least 72 hours or died during therapeutic hypothermia, in neonatal units in England, Wales and Scotland. We will form matched groups in order to perform two comparisons examining: (1) the risk of NEC between infants enterally fed and infants not enterally fed, during therapeutic hypothermia; (2) the risk of late-onset blood stream infections between infants who received intravenous dextrose without any PN and infants who received PN, during therapeutic hypothermia. The following secondary outcomes will also be examined: survival, length of stay, breast feeding at discharge, hypoglycaemia, time to full enteral feeds and growth. Comparison groups will be matched on demographic, maternal, infant and organisational factors using propensity score matching.Ethics and disseminationIn this study, we will use deidentifed data held in the NNRD, an established national population database; parents can opt out of their baby’s data being held in the NNRD. This study holds study-specific Research Ethics Committee approval (East Midlands Leicester Central, 17/EM/0307). These results will help inform optimum nutritional management in infants with HIE receiving therapeutic hypothermia; results will be disseminated through conferences, scientific publications and parent-centred information produced in partnership with parents.Trial registration numberNCT03278847; pre-results,ISRCTN47404296; pre-results.

scholarly journals The management and outcome for patients with chronic subdural hematoma: a prospective, multicenter, observational cohort study in the United Kingdom

2017 ◽  
Vol 127 (4) ◽  
pp. 732-739 ◽  
Author(s):  
Paul M. Brennan ◽  
Angelos G. Kolias ◽  
Alexis J. Joannides ◽  
Jonathan Shapey ◽  
Hani J. Marcus ◽  
...  
Keyword(s):  
United Kingdom ◽  
Clinical Research ◽  
Functional Outcome ◽  
Subdural Hematoma ◽  
Chronic Subdural Hematoma ◽  
Bed Rest ◽  
Repeat Surgery ◽  
Symptomatic Recurrence ◽  
The United Kingdom ◽  
High Flow Oxygen

OBJECTIVESymptomatic chronic subdural hematoma (CSDH) will become an increasingly common presentation in neurosurgical practice as the population ages, but quality evidence is still lacking to guide the optimal management for these patients. The British Neurosurgical Trainee Research Collaborative (BNTRC) was established by neurosurgical trainees in 2012 to improve research by combining the efforts of trainees in each of the United Kingdom (UK) and Ireland's neurosurgical units (NSUs). The authors present the first study by the BNTRC that describes current management and outcomes for patients with CSDH throughout the UK and Ireland. This provides a resource both for current clinical practice and future clinical research on CSDH.METHODSData on management and outcomes for patients with CSDH referred to UK and Ireland NSUs were collected prospectively over an 8-month period and audited against criteria predefined from the literature: NSU mortality < 5%, NSU morbidity < 10%, symptomatic recurrence within 60 days requiring repeat surgery < 20%, and unfavorable functional status (modified Rankin Scale score of 4–6) at NSU discharge < 30%.RESULTSData from 1205 patients in 26 NSUs were collected. Bur-hole craniostomy was the most common procedure (89%), and symptomatic recurrence requiring repeat surgery within 60 days was observed in 9% of patients. Criteria on mortality (2%), rate of recurrence (9%), and unfavorable functional outcome (22%) were met, but morbidity was greater than expected (14%). Multivariate analysis demonstrated that failure to insert a drain intraoperatively independently predicted recurrence and unfavorable functional outcome (p = 0.011 and p = 0.048, respectively). Increasing patient age (p < 0.00001), postoperative bed rest (p = 0.019), and use of a single bur hole (p = 0.020) independently predicted unfavorable functional outcomes, but prescription of high-flow oxygen or preoperative use of antiplatelet medications did not.CONCLUSIONSThis is the largest prospective CSDH study and helps establish national standards. It has confirmed in a real-world setting the effectiveness of placing a subdural drain. This study identified a number of modifiable prognostic factors but questions the necessity of some common aspects of CSDH management, such as enforced postoperative bed rest. Future studies should seek to establish how practitioners can optimize perioperative care of patients with CSDH to reduce morbidity as well as minimize CSDH recurrence. The BNTRC is unique worldwide, conducting multicenter trainee-led research and audits. This study demonstrates that collaborative research networks are powerful tools to interrogate clinical research questions.

scholarly journals The United Kingdom 2009 Swine Flu Outbreak As Recorded in Real Time by General Practitioners

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Hershel Jick ◽  
Dean S. MacLaughlin ◽  
Pascal Egger ◽  
Peter Wiggins
Keyword(s):  
General Practice ◽  
United Kingdom ◽  
Real Time ◽  
General Practitioners ◽  
Swine Flu ◽  
Practice Research ◽  
Research Database ◽  
Planning Stage ◽  
The United Kingdom ◽  
The Uk

Background. Initially the course of the 2009 swine flu pandemic was uncertain and impossible to predict with any confidence. An effective prospective data resource exists in the United Kingdom (UK) that could have been utilized to describe the scope and extent of the swine flu outbreak as it unfolded. We describe the 2009 swine flu outbreak in the UK as recorded daily by general practitioners and the potential use of this database for real-time tracking of flu outbreaks. Methods. Using the General Practice Research Database, a real-time general practice, electronic database, we estimated influenza incidence from July 1998 to September 2009 according to age, region, and calendar time. Results. From 1998 to2008, influenza outbreaks regularly occurred yearly from October to March, but did not typically occur from April to September until the swine flu outbreak began in April 2009. The weekly incidence rose gradually, peaking at the end of July, and the outbreak had largely dissipated by early September. Conclusions. The UK swine flu outbreak, recorded in real time by a large group of general practitioners, was mild and limited in time. Simultaneous online access seemed feasible and could have provided additional clinical-based evidence at an early planning stage of the outbreak.

scholarly journals Dumfries

1991 ◽  
Vol 15 (5) ◽  
pp. 292-294
Author(s):  
R. G. McCreadie
Keyword(s):  
United Kingdom ◽  
Clinical Research ◽  
Patient Care ◽  
Management Team ◽  
Unit Management ◽  
The United Kingdom

My work has four main strands – patient care, membership of the unit management team, clinical research and the College. At different times I can, or have to, place greater or lesser emphasis on any one of these areas – the result is a job virtually devoid of routine. Let me tell you about each area. I hope by doing so you will also learn a little about what is going on in psychiatry north of the border. You will know we arrange things rather differently from the rest of the United Kingdom.

Sign in / Sign up

Export Citation Format

Share Document