scholarly journals The principal role of silicic crustal xenolith assimilation in the formation of Kimberley-type pyroclastic kimberlites – a petrographic study of the Renard 65 kimberlite pipe, Quebec, Canada

2019 ◽  
Keyword(s):  
Kimberlite Pipe ◽  
Principal Role ◽  
Petrographic Study

scholarly journals A Study of Facts and Generating Factors of “Dislike for Exercise” and “Dislike for Physical Education”

2021 ◽  
Vol 10 (1) ◽  
pp. 1-7
Author(s):  
B.Chuluun- Erdene ◽  
D. Azjargal
Keyword(s):  
Physical Education ◽  
Physical Fitness ◽  
Negative Attitude ◽  
Policy Recommendations ◽  
Health And Physical Education ◽  
Principal Role ◽  
Lack Of Exercise ◽  
Governmental Institutions ◽  
Course Of Study

Recently, a decline in children’s fitness and lack of exercise has become a serious issue in Japan. Consequently, various governmental institutions have repeatedly taken up this problem and a number of policy recommendations have been made that aim to remedy the situation. Following these recommendations, the new Course of Study has proposed measures such as increasing the number of teaching hours for health and Physical Education (hereinafter abbreviated as “PE”) and reforming the PE curriculum within 12 years. By doing so, it has further emphasized the need “to develop the capacity and skills to engage in exercise throughout life, to realize an enriching sports life, and to improve physical fitness.” Despite these measures, the polarization between those children who actively engage in exercise and those who do not, as well as children who have an unfavorable or negative attitude toward exercise and PE lessons “Dislike for Exercise (hereinafter abbreviated as “DE”)” and “Dislike for Physical Education (hereinafter abbreviated as “DPE”)” still persist. The principal role of PE lessons at school is to introduce children to the joy and excitement of exercise. Within this context, emphasis should be placed on “PE” education that forms the basis of life-long engagement with sports. However, “DE” and “DPE” attitudes inhibit PE in school from achieving its goals.

U.S. Regulatory Environment

1988 ◽  
Vol 6 (4-5) ◽  
pp. 369-377
Author(s):  
Susan J. Court
Keyword(s):  
Natural Gas ◽  
Environmental Impact ◽  
End Users ◽  
Regulatory Environment ◽  
Principal Role ◽  
The Third ◽  
Natural Gas Prices ◽  
New Construction ◽  
Rate Design

Decontrol of natural gas prices created more competition at the wellhead and the need for greater flexibility in the transportation rules to allow sales directly to end users and distribution without middlemen. In 1987, the Commission issued Order No. 500 which would end the disputes that had arisen by addressing three concerns: take-or-pay, contract demand adjustments, and ‘grand fathering’. The first and the most important was dealt with by a flexible crediting mechanism, the second eliminated and the third of insufficient importance to change the rules. Other issues about natural gas trade of concern to the Commission include: Marketing affiliates which threatened monopolistic practices that have required procedures to eliminate prohibitive practices and to deal with complaints: Rate design, which is the principal role of the Commissions that is treated on an individual basis; Certificate Proceedings for new construction that involve solving issues of rates and environmental impact.

scholarly journals Structure-function analysis of microRNA 3′-end trimming by Nibbler

2020 ◽  
Vol 117 (48) ◽  
pp. 30370-30379
Author(s):  
Wei Xie ◽  
Ivica Sowemimo ◽  
Rippei Hayashi ◽  
Juncheng Wang ◽  
Thomas R. Burkard ◽  
...  
Keyword(s):  
Rna Binding ◽  
Function Analysis ◽  
Principal Role ◽  
Functional Studies ◽  
Surface Patches ◽  
Activity Modeling ◽  
Binding Surface ◽  
Catalytic Cleavage ◽  
Cleavage Motif

Nibbler (Nbr) is a 3′-to-5′ exoribonuclease whose catalytic 3′-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional studies to decipher the contributions of Nbr’s N-terminal domain (NTD) and exonucleolytic domain (EXO) in miRNA 3′-end trimming. We have solved the crystal structures of the NTD core and EXO domains of Nbr, both in the apo-state. The NTD-core domain ofAedes aegyptiNbr adopts a HEAT-like repeat scaffold with basic patches constituting an RNA-binding surface exhibiting a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA). Structure-guided functional assays inDrosophilaS2 cells confirmed a principal role of the NTD in exonucleolytic miRNA trimming, which depends on basic surface patches. Gain-of-function experiments revealed a potential role of the NTD in recruiting Nbr to Argonaute-bound small RNA substrates. The EXO domain ofA. aegyptiandDrosophila melanogasterNbr adopt a mixed α/β-scaffold with a deep pocket lined by a DEDDy catalytic cleavage motif. We demonstrate that Nbr’s EXO domain exhibits Mn2+-dependent ssRNA-specific 3′-to-5′ exoribonuclease activity. Modeling of a 3′ terminal Uridine into the catalytic pocket of Nbr EXO indicates that 2′-O-methylation of the 3′-U would result in a steric clash with a tryptophan side chain, suggesting that 2′-O-methylation protects small RNAs from Nbr-mediated trimming. Overall, our data establish that Nbr requires its NTD as a substrate recruitment platform to execute exonucleolytic miRNA maturation, catalyzed by the ribonuclease EXO domain.

scholarly journals Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells

2011 ◽  
Vol 91 (4) ◽  
pp. 694-702 ◽  
Author(s):  
Carl P. Nelson ◽  
Richard D. Rainbow ◽  
Jennifer L. Brignell ◽  
Matthew D. Perry ◽  
Jonathon M. Willets ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Adenylyl Cyclase ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
K Channel ◽  
Principal Role ◽  
Channel Regulation

A unique diamondiferous peridotite xenolith from the Udachnaya kimberlite pipe, Yakutia: role of subduction in diamond formation

2015 ◽  
Vol 56 (1-2) ◽  
pp. 306-320 ◽  
Author(s):  
A.M. Logvinova ◽  
L.A. Taylor ◽  
E.N. Fedorova ◽  
A.P. Yelisseyev ◽  
R. Wirth ◽  
...  
Keyword(s):  
Kimberlite Pipe ◽  
Peridotite Xenolith ◽  
Diamond Formation
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