scholarly journals It’s In Your Genes: Recent Considerations in Germline versus Somatic Gene Therapy

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Abirami Kirubarajan ◽  
Emily Norris ◽  
John-Paul Oliveria
Keyword(s):  
Gene Therapy ◽  
Somatic Gene Therapy ◽  
Somatic Gene

Somatic Gene Therapy

1991 ◽  
Vol 5 (3) ◽  
pp. 423-432 ◽  
Author(s):  
Charles Hesdorffer ◽  
Dina Markowitz ◽  
Maureen Ward ◽  
Arthur Bank
Keyword(s):  
Gene Therapy ◽  
Somatic Gene Therapy ◽  
Somatic Gene

Correction of the Growth Defect in Dwarf Mice with Nonautologous Microencapsulated Myoblasts—An Alternate Approach to Somatic Gene Therapy

1995 ◽  
Vol 6 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Ayman Al-Hendy ◽  
Gonzalo Hortelano ◽  
Gloria S. Tannenbaum ◽  
Patricia L. Chang
Keyword(s):  
Gene Therapy ◽  
Growth Defect ◽  
Somatic Gene Therapy ◽  
Somatic Gene ◽  
Dwarf Mice

Somatic gene therapy of cancer

1995 ◽  
Vol 121 (S1) ◽  
pp. S37-S37
Author(s):  
M. L. Birnstiel ◽  
T. Schweighoffer ◽  
W. Schmidt ◽  
K. Zatloukal ◽  
G. Maass
Keyword(s):  
Gene Therapy ◽  
Somatic Gene Therapy ◽  
Somatic Gene

Treatment of Inherited Neurometabolic Diseases: The Future

1992 ◽  
Vol 7 (1_suppl) ◽  
pp. S132-S140 ◽  
Author(s):  
Pinar T. Ozand ◽  
Generoso G. Gascon
Keyword(s):  
Gene Therapy ◽  
Bone Marrow ◽  
Autologous Bone Marrow ◽  
Marrow Transplant ◽  
Somatic Gene Therapy ◽  
Autologous Bone Marrow Transplant ◽  
Somatic Gene ◽  
Dividing Cells ◽  
Normal Gene ◽  
Religious Considerations

The past 10 years' experience with bone marrow transplantation from normal, immunologically compatible donors indicates its possible use in various neurometabolic diseases, particularly in a patient who has not suffered irreparable brain damage. This experience may be a prelude to treatment by somatic gene therapy. This can be applied as an autologous bone marrow transplant, grafting the patient's own stem cells inserted with the normal gene. Although somatic gene therapy will be relatively easy for tissues with dividing cells, its application to target tissues with little or no cell division may pose difficulties. Meanwhile, techniques for the preservation, culture, and grafting of fetal neurons in humans have been developed and have been used in the treatment of Parkinson's disease. These procedures could readily be transferred to the treatment of other neurodegenerative diseases that cause significant morbidity, but ethical, legal, and religious considerations must be taken into account. All these efforts promise novel and improved management of inborn neurometabolic errors. (J Child Neurol 1992;7(Suppl):S132-S140.)

The Challenge of Follow-Up for Clinical Trials of Somatic Gene Therapy

1992 ◽  
Vol 3 (6) ◽  
pp. 657-663 ◽  
Author(s):  
Fred D. Ledley ◽  
Baruch Brody ◽  
Claudia A. Kozinetz ◽  
Susan G. Mize
Keyword(s):  
Gene Therapy ◽  
Clinical Trials ◽  
Somatic Gene Therapy ◽  
Somatic Gene

Morphological and Physiological Restorations of Hereditary Form of Dilated Cardiomyopathy by Somatic Gene Therapy

2001 ◽  
Vol 284 (2) ◽  
pp. 431-435 ◽  
Author(s):  
Tomie Kawada ◽  
Aiji Sakamoto ◽  
Mikio Nakazawa ◽  
Masashi Urabe ◽  
Fujiko Masuda ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Dilated Cardiomyopathy ◽  
Somatic Gene Therapy ◽  
Somatic Gene
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