One-Pot, Three-Component Microwave-assisted Synthesis, Characterization and Biological Studies of Imidazo-[1,3]-Oxazines Derivatives under Solvent Free Condition

2018 ◽  
Vol 8 (3) ◽  
pp. 606-616
Author(s):  
S. Srinivasan ◽  
R. Girija ◽  
S. Aruna
Keyword(s):  
Solvent Free ◽  
Microwave Assisted Synthesis ◽  
One Pot ◽  
Free Condition ◽  
Microwave Assisted ◽  
Solvent Free Condition ◽  
Biological Studies

Microwave-assisted synthesis of 3,4-Dihydropyrimidin-2(1H)-ones using acid-functionalized mesoporous polymer

2021 ◽  
Vol 08 ◽  
Author(s):  
Bishwajit Changmai ◽  
Kalyani Rajkumari ◽  
Diparjun Das ◽  
Lalthazuala Rokhum
Keyword(s):  
Biginelli Reaction ◽  
Solid Acid Catalyst ◽  
Solvent Free ◽  
Catalyst Loading ◽  
Microwave Assisted Synthesis ◽  
Diverse Range ◽  
Free Condition ◽  
Microwave Assisted ◽  
Mesoporous Polymer ◽  
Solvent Free Condition

Background: In recent years, 3,4-dihydro-pyrimidin-2-(1H)-ones (DHPMs) have attracting significant attention due to their diverse range of biological properties such as antibacterial, antiviral, antitumor, anti-inflammatory, calcium channel block etc. Taking into account, in this present work a polymer based solid acid catalyst is employed for the microwave-assisted synthesis of DHPMs. Introduction: Multicomponent reactions (MCRs) are attracting utmost attention as it promotes the formation of several bonds in a single process with diverse advantages. Biginelli reaction is the top-ranked example of MCR for the synthesis of dihydropyrimidinones (DHPMs). Solid catalysts are considered as a significant tool for MCRs as they are non-toxic, easy to handle, high selectivity, easy separation process and reusable. Methods: DHPMs synthesis was carried out using acid functionalized mesoporous polymer (AFMP) catalyst under microwave irradiation and solvent-free condition. Results: AFMP showed good to excellent DHPMs yield (89-98%) under the optimized reaction conditions: 1:1:1.2 molar ratio of aldehyde/ethylacetoacetate/urea, catalyst loading of 6 wt.% (with respect to aldehyde), the temperature of 80 °C and microwave power of 500 W. Conclusion: We have successfully utilized microwave-assisted AFMP catalyzed the synthesis of DHPMs under solvent-free condition via Biginelli approach. The catalyst is recyclable and reusable up to 5 consecutive reaction cycles with no significant loss in catalytic activity.

Nanosized ZnO Under Solvent Free Condition: A Smart and Ecofriendly Catalyst to Microwave Assisted Synthesis of 3, 4-dihydropyrimidin-2(1H)- ones/Thiones

2016 ◽  
Vol 1 (1) ◽  
pp. 68-76
Author(s):  
Santosh T. Shinde ◽  
Kaluram G. Kanade ◽  
Bhausaheb K. Karale ◽  
Dinesh P. Amalnerkar ◽  
Nitin M. Thorat ◽  
...  
Keyword(s):  
Solvent Free ◽  
Microwave Assisted Synthesis ◽  
Free Condition ◽  
Microwave Assisted ◽  
Solvent Free Condition ◽  
Nanosized Zno
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