scholarly journals Effect Of Endogenous Noradenaline Release On Peak Exercise Heart Rate In Subjects With Chronic Heart Failure Receiving Carvedilol Versus Metoprolol

2004 ◽  
Vol 6 (1) ◽  
Author(s):  
Timothy Vittorio ◽  
Duygu Onat ◽  
Paolo Colombo ◽  
John Stathopoulos ◽  
Cselaj Sulejman ◽  
...  
2004 ◽  
Vol 10 (4) ◽  
pp. S48
Author(s):  
Timothy J. Vittorio ◽  
Duygu Onat ◽  
Paolo C. Colombo ◽  
John Stathopoulos ◽  
Cselaj Sulejman ◽  
...  

2006 ◽  
Vol 12 (6) ◽  
pp. S13
Author(s):  
Thomas Dewland ◽  
Detlef Wencker ◽  
Ana Silvia Androne ◽  
Katarzyna Hrniewicz ◽  
Stuart D. Katz

1989 ◽  
Vol 256 (1) ◽  
pp. H132-H141 ◽  
Author(s):  
Y. Arai ◽  
J. P. Saul ◽  
P. Albrecht ◽  
L. H. Hartley ◽  
L. S. Lilly ◽  
...  

Fluctuations in heart rate above 0.03 Hz reflect autonomic modulation of sinoatrial node activity. To assess the dynamics of autonomic nervous activity during and immediately after exercise, we determined the power spectrum of heart rate and respiratory fluctuations in 43 normal subjects without known cardiac disease, 8 patients with severe congestive heart failure, and 6 patients status-post cardiac transplantation before, during, and after graded-work load exercise on a cycle ergometer. Before exercise, heart rate fluctuations (spectral power) at both high (0.15-0.80 Hz) and low (0.03-0.15 Hz) frequencies were significantly higher in normal subjects than in either heart failure or transplant patients but were not different between the two groups with heart disease. During exercise, heart rate power at all frequencies rapidly and progressively decreased in normal subjects, until at peak exercise it was not different from the other two groups. During recovery, heart rate power increased in normal subjects but remained significantly below base line. The findings demonstrate a marked reduction of autonomic modulation of heart rate in patients with heart failure and after cardiac transplant and support a progressive withdrawal of vagal activity during exercise with a gradual increase during recovery in normal subjects.


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