GlycoLite™ and helps to reduce body weight: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Acid gelugur fruit (Garcinia atroviridis) is one of the Garcinia families that has long been used as traditional medicine. Gelugur acid has been widely used as a cooking spice by Malay people, but it also has the ability to reduce cholesterol. Besides that, it has antioxidant properties and can reduce body weight and cholesterol. The purpose of this study was to establish specific parameter standards and non-specific parameters from the ethanol extract of acid gelugur fruit. The extract was obtained by maceration method using 70% ethanol with a rendament of 37.15%. Specific parameters include observations of organoleptic extracts of tamarind fruit showed, dark brown, distinctive smelling, and sour. Contains several sekendur metabolites such as flavonoids and saponins. The level of the compound that is soluble in water is 3.6%, while the content of the compound dissolved in ethanol is 3.9%. Total ash content of 2.99%. Non-specific parameters include acid insoluble ash content of 1.03%. The drying rate of geluguric acid simplicia was 7.20%. Water content of sour fruit gelugur extract was 13%.

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Frequency of taking actions to reduce body weight by students with overweight and obesity from the Upper Silesian University

Medycyna Ogólna i Nauki o Zdrowiu ◽

10.5604/20834543.1132052 ◽

2014 ◽

Vol 20 (4) ◽

pp. 439-443

Author(s):

Sandra Kryska

Keyword(s):

Body Weight ◽

Overweight And Obesity ◽

Reduce Body Weight

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Dietary resistant starch and acarbose reduce body weight gain in rodents

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.544.1 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Kathleen L McCutcheon ◽

Michael J Keenan ◽

Jun Zhou ◽

Richard T Tulley ◽

Anne M Raggio ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Resistant Starch ◽

Body Weight Gain ◽

Reduce Body Weight

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How glucagon-like peptide 1 receptor agonists work

Endocrine Connections ◽

10.1530/ec-21-0130 ◽

2021 ◽

Author(s):

Christine Rode Andreasen ◽

Andreas Andersen ◽

Filip Krag Knop ◽

Tina Vilsbøll

Keyword(s):

Body Weight ◽

Therapeutic Potential ◽

Clinical Effects ◽

Glucose Lowering ◽

Receptor Agonists ◽

Reduce Body Weight ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Clinical Utilisation

Recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with low risk of hypoglycaemia, GLP-1RAs reduce body weight and show promising results in reducing cardiovascular risk and renal complications in high-risk individuals with T2D. These findings have changed guidelines on T2D management over the last years, and GLP-1RAs are now widely used in overweight patients with T2D as well as in patients with T2D and cardiovascular disease regardless of glycaemic control. The currently available GLP-1RAs have different pharmacokinetic profiles and differ in their ability to improve glycaemia, reduce body weight and in their cardio- and renal protective potentials. Understanding how these agents work, including insights into their pleiotropic effects on T2D pathophysiology, may improve their clinical utilisation and be useful for exploring other indications such as non-alcoholic steatohepatitis and neurodegenerative disorders. In this review, we provide an overview of approved GLP-1RAs, their clinical effects and mode of actions, and we offer insights into the potential of GLP-1RAs for other indications than T2D. Finally, we will discuss the emerging data and therapeutic potential of using GLP-1RAs in combinations with other receptor agonists.

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Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats

British Journal Of Nutrition ◽

10.1017/s0007114510001017 ◽

2010 ◽

Vol 104 (5) ◽

pp. 624-628 ◽

Cited By ~ 15

Author(s):

Paola Maccioni ◽

Giancarlo Colombo ◽

Antonella Riva ◽

Paolo Morazzoni ◽

Ezio Bombardelli ◽

...

Keyword(s):

Body Weight ◽

Food Intake ◽

Phaseolus Vulgaris ◽

Lever Press ◽

Fixed Ratio ◽

Rodent Models ◽

Self Administration ◽

Dry Extract ◽

Reduce Body Weight ◽

Derivatives Of

Extracts from or derivatives of Phaseolus vulgaris beans reduce body weight and food intake, including highly palatable foods and fluids, in multiple rodent models of overeating and obesity. The present study was designed to assess whether a standardised P. vulgaris dry extract was effective in reducing also the operant self-administration of a chocolate-flavoured beverage. To this end, rats were initially trained to lever-press for a chocolate-flavoured beverage under a fixed ratio 10 schedule of reinforcement in daily 60 min sessions. Once lever-responding reached stable levels, the effect of a P. vulgaris dry extract on the number of lever-responses for the chocolate-flavoured beverage was determined. Pretreatment with 50, 200 and 500 mg (intragastric) P. vulgaris dry extract per kg produced an approximate 15, 35 and 40 % reduction, respectively, in lever-responding for the chocolate-flavoured beverage. These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats.

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