scholarly journals Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen

EFSA Journal ◽  
2012 ◽  
Vol 10 (8) ◽  
pp. 2847 ◽  
Author(s):  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Health Claims ◽  
Vasomotor Symptoms ◽  
Mineral Density ◽  
Scientific Opinion

scholarly journals The Soy Isoflavones for Reducing Bone Loss Study: 3-Yr Effects on pQCT Bone Mineral Density and Strength Measures in Postmenopausal Women

2011 ◽  
Vol 14 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Kristine M. Shedd-Wise ◽  
D. Lee Alekel ◽  
Heike Hofmann ◽  
Kathy B. Hanson ◽  
Dan J. Schiferl ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Mineral Density

scholarly journals Dietary Soy Isoflavones and Bone Mineral Density: Results from the Study of Women's Health Across the Nation

2002 ◽  
Vol 155 (8) ◽  
pp. 746-754 ◽  
Author(s):  
G. A. Greendale ◽  
G. FitzGerald ◽  
M.-H. Huang ◽  
B. Sternfeld ◽  
E. Gold ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Women’S Health ◽  
Women's Health ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Mineral Density ◽  
Density Results

scholarly journals The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2043
Author(s):  
Yuko Tousen ◽  
Ryota Ichimaru ◽  
Takashi Kondo ◽  
Masaki Inada ◽  
Chisato Miyaura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Bone Marrow Cells ◽  
Control Diet ◽  
Soy Isoflavones ◽  
Hindlimb Unloading ◽  
Mineral Density ◽  
Expression Ratio ◽  
Positive Balance

It is well known that physical inactivity during space flight or prolonged bed rest causes rapid bone loss. Soy isoflavones (ISOs) and resveratrol (RES) have been reported to be useful to maintain a positive balance for bone turnover. Therefore, we examined the combined effects of ISO and RES on bone loss that was induced by hindlimb-unloading in mice. Female eight-week-old ddY mice were divided into the following six groups (n = 6–8 each): normally housed mice, loading mice, hindlimb-unloading (UL) mice fed a control diet, UL mice fed a 0.16% ISO conjugates, UL mice fed a 0.15% RES diet, and UL mice fed a 0.16% ISO and 0.15% RES diet. After three weeks, femoral bone mineral density was markedly decreased in unloading mice. The combination of ISO and RES prevented bone loss and especially maintained the trabecular bone mineral density more effectively compared with cortical bones. ISO and/or RES inhibited the increase in the RANKL/OPG expression ratio in bone marrow cells in UL mice. These results suggest that the combination of ISO and RES had a preventive effect against bone loss induced by hindlimb-unloading in mice. These osteoprotective effects of ISO and RES may result from the inhibition of bone resorption.

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