scholarly journals The role of transcription factor genes in the tolerance of common wheat to abiotic stress

2020 ◽  
Author(s):  
E. A. Zaikina ◽  
A. A. Galimova ◽  
B. R. Kuluev
Keyword(s):  
Transcription Factor ◽  
Abiotic Stress ◽  
Common Wheat ◽  
Expression Profile ◽  
Transcriptional Activity ◽  
Steppe Zone ◽  
Transcription Factor Genes

The expression profile of transcription factor genes was studied in varieties of common wheat in the pre-Ural steppe zone in response to drought and hypothermia. Increased transcriptional activity under stress is indicated for the TabZIP1, TabZIP60, TaDREB1, and TaNAC 69 genes.

scholarly journals Mitochondrial Localization of the Yeast Forkhead Factor Hcm1

2020 ◽  
Vol 21 (24) ◽  
pp. 9574
Author(s):  
María José Rodríguez Colman ◽  
Joaquim Ros ◽  
Elisa Cabiscol
Keyword(s):  
Transcription Factor ◽  
Transcriptional Activity ◽  
Spindle Pole ◽  
Respiratory Metabolism ◽  
Mitochondrial Localization ◽  
Transcription Factor Family ◽  
Forkhead Transcription Factor ◽  
Mitochondrial Transcription Factor ◽  
Gradient Density

Hcm1 is a member of the forkhead transcription factor family involved in segregation, spindle pole dynamics, and budding in Saccharomyces cerevisiae. Our group described the role of Hcm1 in mitochondrial biogenesis and stress resistance, and in the cellular adaptation to mitochondrial respiratory metabolism when nutrients decrease. Regulation of Hcm1 activity occurs at the protein level, subcellular localization, and transcriptional activity. Here we report that the amount of protein increased in the G1/S transition phase when the factor accumulated in the nucleus. In the G2/M phases, the Hcm1 amount decreased, and it was translocated outside the nucleus with a network-like localization. Preparation of highly purified mitochondria by a sucrose gradient density demonstrated that Hcm1 colocalized with mitochondrial markers, inducing expression of COX1, a mitochondrial encoded subunit of cytochrome oxidase, in the G2/M phases. Taken together, these results show a new localization of Hcm1 and suggest that it acts as a mitochondrial transcription factor regulating the metabolism of this organelle.

scholarly journals Multivalency regulates activity in an intrinsically disordered transcription factor

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Sarah Clark ◽  
Janette B Myers ◽  
Ashleigh King ◽  
Radovan Fiala ◽  
Jiri Novacek ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcriptional Activity ◽  
Target Gene ◽  
Intrinsic Disorder ◽  
Negative Cooperativity ◽  
Intrinsically Disordered ◽  
Main Target ◽  
Recognition Motifs ◽  
Cellular Transcription

The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1). Using a combination of biophysical methods, structural analysis by NMR and electron microscopy, and cellular transcription assays, we developed a model that proposes a concerted role of intrinsic disorder and multiple LC8 binding events in regulating LC8 transcription. We demonstrate that the long intrinsically disordered C-terminal domain of ASCIZ binds LC8 to form a dynamic ensemble of complexes with a gradient of transcriptional activity that is inversely proportional to LC8 occupancy. The preference for low occupancy complexes at saturating LC8 concentrations with both human and Drosophila ASCIZ indicates that negative cooperativity is an important feature of ASCIZ-LC8 interactions. The prevalence of intrinsic disorder and multivalency among transcription factors suggests that formation of heterogeneous, dynamic complexes is a widespread mechanism for tuning transcriptional regulation.

scholarly journals Congenital dyserythropoietic anemias: molecular insights and diagnostic approach

Blood ◽  
2013 ◽  
Vol 122 (13) ◽  
pp. 2162-2166 ◽  
Author(s):  
Achille Iolascon ◽  
Hermann Heimpel ◽  
Anders Wahlin ◽  
Hannah Tamary
Keyword(s):  
Transcription Factor ◽  
Molecular Diagnosis ◽  
Critical Role ◽  
Diagnostic Approach ◽  
Transcription Factor Genes ◽  
Hereditary Disorders

Abstract The congenital dyserythropoietic anemias (CDAs) are hereditary disorders characterized by distinct morphologic abnormalities of marrow erythroblasts. The unveiling of the genes mutated in the major CDA subgroups (I-CDAN1 and II-SEC23B) has now been completed with the recent identification of the CDA III gene (KIF23). KIF23 encodes mitotic kinesin-like protein 1, which plays a critical role in cytokinesis, whereas the cellular role of the proteins encoded by CDAN1 and SEC23B is still unknown. CDA variants with mutations in erythroid transcription factor genes (KLF1 and GATA-1) have been recently identified. Molecular diagnosis of CDA is now possible in most patients.

scholarly journals Expression Profile Matrix of Arabidopsis Transcription Factor Genes Suggests Their Putative Functions in Response to Environmental Stresses

2002 ◽  
Vol 14 (3) ◽  
pp. 559-574 ◽  
Author(s):  
Wenqiong Chen ◽  
Nicholas J. Provart ◽  
Jane Glazebrook ◽  
Fumiaki Katagiri ◽  
Hur-Song Chang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Expression Profile ◽  
Environmental Stresses ◽  
Transcription Factor Genes

Expression profile of cytokine and transcription factor genes during embryonic development of zebrafish Danio rerio

2008 ◽  
Vol 74 (2) ◽  
pp. 391-396 ◽  
Author(s):  
Kanako ITO ◽  
Fumio TAKIZAWA ◽  
Yasutoshi YOSHIURA ◽  
Mitsuru OTOTAKE ◽  
Teruyuki NAKANISHI
Keyword(s):  
Transcription Factor ◽  
Embryonic Development ◽  
Expression Profile ◽  
Danio Rerio ◽  
Transcription Factor Genes
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