scholarly journals Analysis of the antibacterial activity of ampicillin by biological sensor based on a microwave resonator

2020 ◽  
Author(s):  
O. I. Guliy ◽  
B. D. Zaitsev ◽  
A. V. Smirnov ◽  
O. A. Karavaeva ◽  
A. K.M. Alsowaidi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Analysis Time ◽  
Microwave Resonator ◽  
Antibacterial Drugs ◽  
Biological Sensor

A method has been developed for analyzing the activity of antibacterial drugs on ampicillin as example by using a biological sensor based on a microwave resonator with an analysis time of ~ 15 minutes.

Preparing natural biocomposites of N-quaternary chitosan with antibacterial activity to reduce consumption of antibacterial drugs

2019 ◽  
Vol 371 ◽  
pp. 224-232 ◽  
Author(s):  
Marieh Ghazaie ◽  
Mehran Ghiaci ◽  
Sabihe Soleimanian-Zad ◽  
Sheila Behzadi-teshnizi
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Drugs

scholarly journals Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity

2021 ◽  
Author(s):  
Przemysław Biegański ◽  
Łukasz Szczupak ◽  
Manuel Arruebo ◽  
Konrad Kowalski
Keyword(s):  
Antibacterial Activity ◽  
Pathogenic Bacteria ◽  
Drug Resistant ◽  
Antibacterial Drugs ◽  
Recent Developments ◽  
Resistant Strains ◽  
Drug Resistant Strains

Recent developments in the field of organometalated antibacterial drugs and metal-based materials with antibacterial activity are reviewed. They emerge as attractive candidates for combating pathogenic bacteria including drug resistant strains.

scholarly journals Structure-Antibacterial Activity Relationships Of N-Substituted-(D-/L-Alaninyl) 1H-1,2,3-Triazolylmethyl Oxazolidinones

2018 ◽  
Author(s):  
Oludotun Phillips ◽  
Edet Ekpenyong Udo ◽  
Roselyn Jennifer D’silva
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Bacterial Resistance ◽  
Clinical Usefulness ◽  
Antibacterial Resistance ◽  
Bacterial Strains ◽  
Gram Positive ◽  
Resistance Development ◽  
Antibacterial Drugs ◽  
Gram Negative

Bacterial resistance towards existing class of antibacterial drugs continues to increase posing significant threat to clinical usefulness of these drugs. This increasing and alarming rates of antibacterial resistance development and the decline in the number of new antibacterial drugs approval continue to serve as major impetus for research into discovery and development of new antibacterial agents. We synthesized a series D-/L-alaninyl substituted triazolyl oxazolidinone derivatives and evaluated their antibacterial activity against selected standard Gram-positive and Gram-negative bacterial strains. Overall, the compounds showed moderate to strong antibacterial activity. Compounds 9d and 10d (D- and L-alaninyl derivatives bearing 3,5-dinitrobenzoyl substituent), 10e (D-alaninyl derivative bearing 5-nitrofurancarbonyl group) and 9f and 10f (D- and L-alaninyl derivatives bearing 5-nitrothiophene carbonyl moiety) demonstrated antibacterial activity (MIC:2 g/mL) against S. aureus, S. epidermidis, E. faecalis and M. catarrhalis standard bacterial strains. No significant differences were noticeable between the antibacterial activity of the D- and L-alaninyl derivatives as a result of the stereochemistry of the compounds.

scholarly journals Phytochemical analysis, antibacterial activity and antibiotic modifying action of Jatropha mollissima (Pohl.) Baill. (Euphorbiaceae)

2020 ◽  
pp. 85-94
Author(s):  
Noelly Bastos-Cavalcante ◽  
Cristina Rodrigues dos Santos-Barbosa ◽  
Raimundo Luiz Silva-Pereira ◽  
Débora Feitosa-Muniz ◽  
Henrique Douglas de Melo-Coutinho ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Antibacterial Activity ◽  
Side Effects ◽  
Phytochemical Analysis ◽  
Bacterial Strains ◽  
Antibacterial Drugs ◽  
Antibacterial Compounds ◽  
Caatinga Biome ◽  
Phytochemical Profile

La aparición de cepas bacterianas resistentes y los efectos secundarios de sus fármacos disponibles han hecho investigar nuevos compuestos antibacterianos bioactivos. Jatropha mollissima es una planta endémica del bioma Caatinga, Brasil. Existen informes en la literatura de que esta especie tiene acción antioxidante, antibacteriana y antiproliferativa. El presente estudio tuvo como objetivo evaluar el potencial antibacteriano y modulador de J. mollissima contra cepas bacterianas multirresistentes. El perfil fitoquímico se obtuvo por cromatografía de gases junto con espectrometría de masas. J. mollissima mostró actividad antibacteriana moderada y moduló la actividad del antibiótico Norfloxacino, promoviendo una relación antagonista. Este fue el primer estudio de este tipo realizado con J. mollissima. The emergence of resistant bacterial strains and the significant increase in side effects of currently available antibacterial drugs have made it urgent to develop research to identify new bioactives antibacterial compounds. Jatropha mollissima is a plant endemic to the Caatinga biome, Brazil and this species has antioxidant, antibacterial and antiproliferative action. The present study aimed to evaluate the antibacterial and modulatory potentials of J. mollissima against multiresistant bacterial strains. The phytochemical profile was obtained from gas chromatography coupled to mass spectrometry. J. mollissima presented moderate antibacterial activity and modulated the activity of the antibiotic Norfloxacin, promoting an antagonistic relationship. This was the first study of this nature carried out with J. mollissima.

Moist Wound Dressing Fabrications: Carboxymethylation of Antibacterial Cotton Gauze

2013 ◽  
Vol 8 (4) ◽  
pp. 155892501300800 ◽  
Author(s):  
Elayarajah Balasubramanian ◽  
Venkatrajah Balasubramanian ◽  
Geethu Babu ◽  
S. Devika ◽  
R. Rajendran
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
The Other ◽  
Antibacterial Drugs ◽  
Cotton Gauze ◽  
Drug Concentrations ◽  
Two Samples ◽  
The Impact ◽  
Dressing Materials ◽  
Wound Dressing Materials

Cotton gauze wound dressing materials were carboxymethylated in order to maintain moist conditions by increasing the carboxyl contents on their cellulose moieties. Also, to improve their antibacterial efficacy, two synergistic drugs were treated after carboxymethylation. Carboxymethylation of the fabrics was carried out using different concentrations of sodium hydroxide/mono chloro acetic acid (NaOH/MCA) to increase the carboxyl contents (85, 173, 246 mmol/100g). To acquire moist conditions of the fabrics, the carboxyl contents of the gelling samples were made in Ca/Na forms (Na ions was replaced by Ca ions) in three different forms of degree of neutralization (10/90, 20/80, and 30/70). The first non-gelling sample (85 mmol/100g) was left in its Na form to differentiate its chemical and biological properties from the other two samples. In order to fabricate the carboxymethylated (CM) cotton with antibacterial drugs, all the samples were padded in different concentrations (100, 500 and 1000 mg/L) of two synergistic drugs: ofloxacin and ornidazole. These samples were considered as carboxymethylated antimicrobial dressings (CM-AMD). The impact of antibacterial drug content on swelling, gelling, and shrinkage was determined along with the antibacterial activity. Both qualitative and quantitative antibacterial activity was measured for CM-AMD samples. Among the three samples, the first sample (85 mmol/100g) showed no gelling in phosphate buffered saline (PBS), whereas the other two samples (173 and 246 mmol/100g) showed gelling visually. In the present research, it was observed that swelling and shrinkage slightly decreased by increasing the concentrations of antibacterial drugs; and increased by increasing the carboxyl content. The antibacterial activity of CM-AMD when tested qualitatively showed that, the inhibition clear zone (ICZ) increased by increasing drug concentrations and carboxyl contents; but decreased by increasing the degree of neutralization. Quantitative bacterial reduction testing showed 100 % reduction of the test organisms (Staphylococcus aureus and Peptostreptococcus sp) The study concludes that carboxymethylated cotton gauzy fabrics containing more carboxyl contents (≥ 246 mmol/100g) with less degree of neutralization (10 %) treated with synergistic antibacterial drugs could be suitable for fabricating antibacterial wound dressing materials.

scholarly journals Analysis of Amoxicillin’s Antibacterial Activity Using Biological Sensor With Clit Acoustic Wave

2021 ◽  
Vol 66 (1-2) ◽  
pp. 12-18
Author(s):  
О. I. Guliy ◽  
В. D. Zaitsev ◽  
О. S. Larionova ◽  
A. M. Alsowaidi ◽  
О. A. Karavaeva ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Acoustic Wave ◽  
Cell Suspension ◽  
Bottom Plate ◽  
Activity Assay ◽  
Horizontal Polarization ◽  
Express Analysis ◽  
First Time ◽  
Biological Sensor

The possibility of antibacterial activity assay using an acoustic non-contact biological sensor based on two piezoelectric plates separated by an air gap was demonstrated on the example of amoxicillin and Escherichia coli for the first time. An acoustic wave with transverse horizontal polarization is excited in the bottom plate of the sensor. The upper plate serves as the bottom of the container with the studied cell suspension. It was shown that the addition of an antibiotic to the cell suspension leads to a change in the parameters of the sensor. The effect of amoxicillin on microbial cells was monitored by laser microscopy and standard microbiological culture. The possibility of express analysis of the drug’s antibacterial activity using a biological sensor based on the use of a slit acoustic wave is shown. 

scholarly journals Structure-Antibacterial Activity Relationships of N-Substituted-(d-/l-Alaninyl) 1H-1,2,3-Triazolylmethyl Oxazolidinones

2018 ◽  
Vol 86 (4) ◽  
pp. 42
Author(s):  
Oludotun Phillips ◽  
Edet Udo ◽  
Roselyn D’silva
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Moraxella Catarrhalis ◽  
Antibacterial Agents ◽  
Bacterial Resistance ◽  
Antibacterial Resistance ◽  
Bacterial Strains ◽  
Resistance Development ◽  
Antibacterial Drugs ◽  
Gram Negative

Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs. These increasing and alarming rates of antibacterial resistance development and the decline in the number of new antibacterial drugs’ approval continue to serve as a major impetus for research into the discovery and development of new antibacterial agents. We synthesized a series of d-/l-alaninyl substituted triazolyl oxazolidinone derivatives and evaluated their antibacterial activity against selected standard Gram-positive and Gram-negative bacterial strains. Overall, the compounds showed moderate to strong antibacterial activity. Compounds 9d and 10d (d- and l-alaninyl derivatives bearing the 3,5-dinitrobenzoyl substituent), 10e (l-alaninyl derivative bearing the 5-nitrofurancarbonyl group) and 9f and 10f (d- and l-alaninyl derivatives bearing the 5-nitrothiophene carbonyl moiety) demonstrated antibacterial activity (MIC: 2 µg/mL) against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Moraxella catarrhalis standard bacterial strains. No significant differences were noticeable between the antibacterial activity of the d- and l-alaninyl derivatives as a result of the stereochemistry of the compounds.

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