scholarly journals Biochemical and histopathological evaluation of taxifolin: An experimental study in a rat model of liver ischemia reperfusion injury

2019 ◽  
Author(s):  
Huseyin Eken ◽  
Eray Kurnaz
Keyword(s):  
Experimental Study ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Histopathological Evaluation

scholarly journals The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

2016 ◽  
Vol 43 (2) ◽  
pp. 11-20 ◽  
Author(s):  
C. Τsompos ◽  
C. Panoulis ◽  
K. Τοutouzas ◽  
A. Triantafyllou ◽  
G. Ζografos ◽  
...  
Keyword(s):  
Experimental Study ◽  
Antioxidant Capacity ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Short Term ◽  
Short Term Effects

SummaryThis experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. Albumin levels were measured at 60th min of reperfusion (groups A and C) and at 120th min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted albumin levels by 3.63% ± 0.87% (p = 0.0001). Reperfusion time non-significantly increased the predicted albumin levels by 0.72% ± 1.04% (p = 0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted albumin levels by 2.02% ± 0.54% (p = 0.0005). U-74389G administration whether it interacted or not with reperfusion time has significant decreasing short - term effects on albumin levels. It seems that the antioxidant capacity is associated with albumin catabolism.

scholarly journals Benidipine can prevent liver ischemia reperfusion injury in rats: a biochemical and histopathological evaluation

2019 ◽  
Vol 33 (1) ◽  
pp. 1645-1652
Author(s):  
Orhan Cimen ◽  
Hüseyin Eken ◽  
Ferda Keskin Cimen ◽  
Asli Ozbek Bilgin ◽  
Kamil Pehlivanoglu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Histopathological Evaluation

scholarly journals Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model

2019 ◽  
Vol 2 (3) ◽  
pp. 93-102
Author(s):  
Kerem Akkoca ◽  
Mustafa Sit ◽  
Hamit Yoldas ◽  
Ibrahim Karagoz ◽  
Isa Yildiz ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Magnesium Sulphate ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

scholarly journals Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model

2008 ◽  
Vol 23 (4) ◽  
pp. 378-383 ◽  
Author(s):  
Antonio Roberto Franchi Teixeira ◽  
Nilza Trindade Molan ◽  
Marta Bellodi-Privato ◽  
Ana Maria Coelho ◽  
Kátia Ramos Leite ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Classical Model ◽  
Control Group ◽  
Standard Diet ◽  
Liver Ischemia ◽  
Hepatic Ischemia ◽  
Histological Assessment

PURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.

scholarly journals The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats

2016 ◽  
Vol 22 (4) ◽  
pp. 264-269
Author(s):  
C. Tsompos ◽  
C. Panoulis ◽  
K. Toutouzas ◽  
Triantafyllou Aggeliki ◽  
G. Zografos ◽  
...  
Keyword(s):  
Experimental Study ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Study Time ◽  
Combined Effect ◽  
Short Term ◽  
Testosterone Levels ◽  
Short Term Effects

Abstract Objective: This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an adrenal ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean testosterone levels (T). Materials and methods: 40 rats of mean weight 247.7 g were used in the study. T levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results: Erythropoietin administration non significantly increased the testosterone levels by 71.21%+44.19% (p=0.1080). Reperfusion time non-significantly decreased the testosterone levels by 65.17%+44.45% (p=0.0792). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in increasing the testosterone levels by 27.65%+27.21% (p= 0.3006). Conclusions: Erythropoietin administration whether it interacted or not with reperfusion time has increasing non significant short-term effects on testosterone levels. Perhaps, a longer study time or a higher Epo dose, may reveal clearer and more significant effects.

The Effect of Erythropoietin on Amylase Levels during Ischemia-Reperfusion Injury in Rats

2016 ◽  
Vol 50 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Constantinos Tsompos ◽  
Constantinos Panoulis ◽  
Konstantinos Toutouzas ◽  
George Zografos ◽  
Apostolos Papalois
Keyword(s):  
Experimental Study ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Combined Effect ◽  
Short Term ◽  
Baseline Values

ABSTRACT The aim of this experimental study was to examine the effect of erythropoietin (EPO) on rat model and particularly in an ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean amylase levels. Materials and methods Forty rats of mean weight 247.7 gm were used in the study. Amylase levels were measured at 60 minutes (groups A and C) and at 120 minutes (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results Erythropoietin administration kept non-significantly increased the A levels by 5.04 ± 6.12% (p = 0.3831). Reperfusion time kept non-significantly increased the A levels by 10.08 ± 5.95% (p = 0.0615). However, EPO administration and reperfusion time together produced a non-significant combined effect in keeping increased the A levels by 4.36 ± 3.65% (p = 0.2258) Conclusion Erythropoietin administration, reperfusion time and their interaction kept non-significantly short-term increased the amylase levels. The restorating effect of Epo is satisfactory, since it reduced the discrepancy from baseline values at non-significant level. How to cite this article Tsompos C, Panoulis C, Toutouzas K, Zografos G, Papalois A. The Effect of Erythropoietin on Amylase Levels during Ischemia-Reperfusion Injury in Rats. J Postgrad Med Edu Res 2016;50(1):18-21.

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