Clinical Presentation and Diagnostic Workup including Classification of Degenerative Thoracic and Lumbar Disc Disorders

2017 ◽  
Author(s):  
Enrico Tessitore
Keyword(s):  
Clinical Presentation ◽  
Lumbar Disc ◽  
Diagnostic Workup

Danon Disease: Clinical Presentation and Diagnostic Workup in a Case of a Male Patient with a Novel Mutation in the LAMP2 Gene

2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
A. Dieckmann ◽  
F. Majer ◽  
H. Hulkova ◽  
M. Farr ◽  
T. Kalina ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Presentation ◽  
Novel Mutation ◽  
Diagnostic Workup ◽  
Danon Disease ◽  
Lamp2 Gene

Clinical Epidemiology of Coronavirus Disease 2019:Defined on Current Research

2020 ◽  
pp. 54-72 ◽  
Author(s):  
Fengyu Zhang ◽  
Claude Hughes
Keyword(s):  
Clinical Presentation ◽  
Population Distribution ◽  
Clinical Epidemiology ◽  
Case Fatality ◽  
Immunological Response ◽  
Prevention Strategies ◽  
Clinical Type ◽  
Global Pandemic ◽  
Potential Therapeutics

Coronavirus disease 2019 (COVID-19) is a new infectious respiratory disease that has caused the ongoing global pandemic. The primary purpose of this article is to describe evolving clinical epidemiology of COVID-19, including 1) infection and testing, 2) clinical spectrum including classification of clinical type, asymptomatic cases, severe cases and comorbidity, and clinical and immunological response, 3) regional variation in clinical presentation, 4) population distribution by age, sex, and occupation, and finally, 5) case-fatality. This content may provide important information on detailed clinical type and presentation of the disease, in which appropriate clinical outcomes can be derived for developing prevention strategies and clinical studies or trials that aim to test potential therapeutics or products for different patient populations.

scholarly journals Panniculitis in Children

2021 ◽  
Vol 8 (3) ◽  
pp. 315-336
Author(s):  
Isabelle Moulonguet ◽  
Sylvie Fraitag
Keyword(s):  
Clinical Presentation ◽  
Inflammatory Diseases ◽  
Secondary Process ◽  
Immune Disorders ◽  
Lesion Site ◽  
Heterogenous Group ◽  
Systemic Disorder ◽  
Diagnosis And Classification ◽  
Subcutaneous Adipose

Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules. Although the patient’s age and the lesion site provide information, a histopathological assessment is sometimes required for a definitive diagnosis and classification of the disorder. In children, most panniculitides are lobular. At present, autoimmune inflammatory diseases and primary immunodeficiencies have been better characterised; panniculitis can be the presenting symptom in some of these settings. Unexplained panniculitis in a young child should prompt a detailed screen for monogenic immune disorders because the latter usually manifest themselves early in life. Here, we review forms of panniculitis that occur primarily in children, with a focus on newly described entities.

Sarcoidosis Presenting as Nasal Obstruction

1993 ◽  
Vol 7 (3) ◽  
pp. 133-138 ◽  
Author(s):  
Mark J. Shikowitz ◽  
Aijaz Alvi
Keyword(s):  
Respiratory Tract ◽  
Nasal Obstruction ◽  
Clinical Presentation ◽  
Multiple Organ ◽  
Diagnostic Workup ◽  
Unknown Etiology ◽  
Granulomatous Disease ◽  
Upper Respiratory Tract ◽  
Important Symptom ◽  
Upper Respiratory

Sarcoidosis is a chronic systemic granulomatous disease of unknown etiology. The histology of this disease was first reported by Boeck in 1899. Since that time many reports of multiple organ involvement have been published. Symptoms relating to the upper respiratory tract are not uncommon. Nasal obstruction as the presenting and primary complaint in sarcoidosis however is a rare but important symptom as it may lead to the diagnosis of this treatable disease. We present three patients whose initial complaint of progressive nasal obstruction heralded the diagnosis of sarcoidosis upon further workup. The clinical presentation, diagnostic workup, histology, and management of nasal sarcoidosis are discussed.

Borderline conditions in dermato-oncology

2021 ◽  
pp. 49-59
Author(s):  
S. P. Seleznev ◽  
O. B. Tamrazova ◽  
V. Yu. Sergeev ◽  
V. G. Nikitaev ◽  
A. N. Pronichev
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Presentation ◽  
Digital Processing ◽  
Review Article ◽  
Diagnostic Systems ◽  
Stepwise Approach ◽  
Cascade Models ◽  
Precancerous State

This review article provides an overview of the etiology, pathogenesis, clinical presentation, diagnosis, and treatment methods for actinic keratosis, keratoacanthoma, and Bowen’s disease. The provoking factors are described, where the main importance is attached to insolation, previous immunosuppression and immunodeficiency and trauma. The pathogenesis of these diseases is described in the form of cascade models. Various clinical forms and their main dermatoscopic features, suitable for digital processing in automated diagnostic systems, are presented. A stepwise approach to the treatment of these nosologies is described, and a preliminary prognosis is assessed based on the duration of progression and the likelihood of transformation into squamous cell carcinoma. Given the fact that dermato-oncologists have not yet come to a consensus on the classification of the described diseases, in this article they are considered as a borderline, thereby demonstrating a fine line of transition from a precancerous state to cancer in situ.

scholarly journals Chronic subdural hematoma - diagnosis, treatment and perspectives

2020 ◽  
Vol 73 (9-10) ◽  
pp. 295-300
Author(s):  
Mirela Jukovic ◽  
Viktor Till
Keyword(s):  
Computed Tomography ◽  
Subdural Hematoma ◽  
Diagnostic Method ◽  
Clinical Presentation ◽  
Management Strategies ◽  
Disease Onset ◽  
Chronic Subdural Hematoma ◽  
Disease Therapy ◽  
Conservative And Surgical Treatment

Introduction. Chronic subdural hematoma has become an important entity in radiological, neurological and neurosurgery practice. Classification. The classification of chronic subdural hematoma is most often done in relation to the time of the disease onset (acute, subacute and chronic), whereas the second classification is based on hematoma density using computed tomography. Clinical presentation. The clinical presentation may mimic a spectrum of various diseases and chronic subdural hematoma can be easily overlooked without radiological verification. Diagnosis. The diagnosis of chronic subdural hematoma is partly clinical and partly radiological. In most cases, computed tomography is the initial diagnostic method for detection of this disease. Many studies point to different management strategies in the diagnosis and treatment of the disease. Therapy. The therapy of chronic subdural hematoma depends on the patient?s neurological deficit, but generally it is divided into conservative and surgical treatment. Conclusion. The aim of this paper is to review chronic subdural hematomas with reference to their clinical and radiological characteristics for better understanding of these phenomena.

scholarly journals The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations

2017 ◽  
Vol 29 (2) ◽  
pp. 680-693 ◽  
Author(s):  
Volker Nickeleit ◽  
Harsharan K. Singh ◽  
Parmjeet Randhawa ◽  
Cinthia B. Drachenberg ◽  
Ramneesh Bhatnagar ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Working Group ◽  
Classification Scheme ◽  
Clinical Presentation ◽  
Interstitial Fibrosis ◽  
The United States ◽  
Systematic Analysis ◽  
Definition Of ◽  
Morphologic Classification

Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence of approximately 5%. A generally accepted morphologic classification of definitive PVN that groups histologic changes, reflects clinical presentation, and facilitates comparative outcome analyses is lacking. Here, we report a morphologic classification scheme for definitive PVN from the Banff Working Group on Polyomavirus Nephropathy, comprising nine transplant centers in the United States and Europe. This study represents the largest systematic analysis of definitive PVN undertaken thus far. In a retrospective fashion, clinical data were collected from 192 patients and correlated with morphologic findings from index biopsies at the time of initial PVN diagnosis. Histologic features were centrally scored according to Banff guidelines, including additional semiquantitative histologic assessment of intrarenal polyomavirus replication/load levels. In-depth statistical analyses, including mixed effects repeated measures models and logistic regression, revealed two independent histologic variables to be most significantly associated with clinical presentation: intrarenal polyomavirus load levels and Banff interstitial fibrosis ci scores. These two statistically determined histologic variables formed the basis for the definition of three PVN classes that correlated strongest with three clinical parameters: presentation at time of index biopsy, serum creatinine levels/renal function over 24 months of follow-up, and graft failure. The PVN classes 1–3 as described here can easily be recognized in routine renal biopsy specimens. We recommend using this morphologic PVN classification scheme for diagnostic communication, especially at the time of index diagnosis, and in scientific studies to improve comparative data analysis.

Fourth branchial arch sinus: Clinical presentation, diagnostic workup, and surgical treatment

1999 ◽  
Vol 109 (3) ◽  
pp. 442-446 ◽  
Author(s):  
Caroline Yang ◽  
James Cohen ◽  
Edwin Everts ◽  
James Smith ◽  
James Caro ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Clinical Presentation ◽  
Branchial Arch ◽  
Diagnostic Workup
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